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  1. The discovery of sodium-glucose co-transporter 2 (SGLT2) inhibitors, with a novel mechanism independent of insulin secretion or sensitization, bring about a new therapeutic approach to the management of type 2...

    Authors: Asres Berhan and Alex Barker
    Citation: BMC Endocrine Disorders 2013 13:58
  2. Lifestyle intervention in type 2 diabetes mellitus (T2DM) is effective but needs a special local setting and is costly. Therefore, in a randomized-controlled trial we tested the hypothesis that the autonomous ...

    Authors: Kerstin Kempf and Stephan Martin
    Citation: BMC Endocrine Disorders 2013 13:57
  3. The complex process of development of the pituitary gland is regulated by a number of signalling molecules and transcription factors. Mutations in these factors have been identified in rare cases of congenital...

    Authors: Jana Breitfeld, Susanne Martens, Jürgen Klammt, Marina Schlicke, Roland Pfäffle, Kerstin Krause, Kerstin Weidle, Dorit Schleinitz, Michael Stumvoll, Dagmar Führer, Peter Kovacs and Anke Tönjes
    Citation: BMC Endocrine Disorders 2013 13:56
  4. Around 10 per cent of catecholamine-secreting tumours can be found outside the adrenal medulla (paraganglioma). We report a case of a functional sporadic paraganglioma that was localized lateral to the prostat...

    Authors: Jesper Kers, Zaheeb A Choudhry, Ton A Roeleveld and Alexander PJ Houdijk
    Citation: BMC Endocrine Disorders 2013 13:55
  5. Allograft inflammatory factor 1 (AIF-1) is a putative obesity gene. Our aim was to examine the expression of AIF-1 in human white adipose tissue (WAT) in relation to obesity and metabolic phenotypes in women.

    Authors: Silvia Lorente-Cebrián, Pauline Decaunes, Elisabeth Dungner, Anne Bouloumié, Peter Arner and Ingrid Dahlman
    Citation: BMC Endocrine Disorders 2013 13:54
  6. Self-management is recognized as the cornerstone of overall diabetes management. Web-based self-management programs have the potential of supporting type 2 diabetes patients with managing their diabetes and re...

    Authors: Michael van Vugt, Maartje de Wit, Steven H Hendriks, Yvonne Roelofsen, Henk JG Bilo and Frank J Snoek
    Citation: BMC Endocrine Disorders 2013 13:53
  7. Testing for 25-hydroxyvitamin D [25(OH)D] has increased dramatically in recent years. The present report compares overall utilization and results for 25(OH)D orders at two academic medical centers - one in New...

    Authors: Jonathan R Genzen, Jennifer T Gosselin, Thomas C Wilson, Emilian Racila and Matthew D Krasowski
    Citation: BMC Endocrine Disorders 2013 13:52
  8. Over the last few years, awareness and detection rates of hypopituitarism following traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) has steadily increased. Moreover, recent studies have found th...

    Authors: Steffen Kristian Fleck, Henri Wallaschofski, Christian Rosenstengel, Marc Matthes, Thomas Kohlmann, Matthias Nauck, Henry Werner Siegfried Schroeder and Christin Spielhagen
    Citation: BMC Endocrine Disorders 2013 13:51
  9. Iodine deficiency affects nearly 1.9 billion people worldwide, but it can be prevented by salt iodization. This cross-sectional survey assessed current iodine status, iodized salt coverage and risk factors for...

    Authors: Barbara Matthys, Mohbegim Davlatmamadova, Gulzira Karimova, Vreni Jean-Richard, Michael B Zimmermann and Kaspar Wyss
    Citation: BMC Endocrine Disorders 2013 13:50
  10. Immigrants from South Asia to Western countries have a high prevalence of type 2 diabetes mellitus (T2DM). We explored pathogenic factors that might contribute to the high risk of T2DM in Pakistani immigrants ...

    Authors: Cecilie Wium, Erlend T Aasheim, Thor Ueland, Annika E Michelsen, Per M Thorsby, Ingegerd F Larsen, Peter A Torjesen, Pål Aukrust and Kåre I Birkeland
    Citation: BMC Endocrine Disorders 2013 13:49
  11. Familial papillary thyroid cancer (fPTC) is recognized as a distinct entity only recently and no fPTC predisposing genes have been identified. Several potential regions and susceptibility loci for sporadic PTC...

    Authors: Shunyao Liao, Wenzhong Song, Yunqiang Liu, Shaoping Deng, Yaming Liang, Zhenlin Tang, Jiyuan Huang, Dandan Dong and Gang Xu
    Citation: BMC Endocrine Disorders 2013 13:48
  12. Insulin resistance has been associated with metabolic and hemodynamic alterations and higher cardio metabolic risk. There is great variability in the threshold homeostasis model assessment of insulin resistanc...

    Authors: Pilar Gayoso-Diz, Alfonso Otero-González, María Xosé Rodriguez-Alvarez, Francisco Gude, Fernando García, Angel De Francisco and Arturo González Quintela
    Citation: BMC Endocrine Disorders 2013 13:47
  13. To examine the views and current practice of SMBG among Black Caribbean and South Asian individuals with non-insulin treated Type 2 diabetes mellitus.

    Authors: Enza Gucciardi, Mariella Fortugno, Andrea Senchuk, Heather Beanlands, Elizabeth McCay and Elizabeth E Peel
    Citation: BMC Endocrine Disorders 2013 13:46
  14. Diffuse large B-cell lymphoma sometimes involves the endocrine organs, but involvement of both the pituitary and adrenal glands is extremely rare. Involvement of these structures can lead to hypopituitarism an...

    Authors: Yasuhiro Nakashima, Motoaki Shiratsuchi, Ichiro Abe, Yayoi Matsuda, Noriyuki Miyata, Hirofumi Ohno, Motohiko Ikeda, Takamitsu Matsushima, Masatoshi Nomura and Ryoichi Takayanagi
    Citation: BMC Endocrine Disorders 2013 13:45
  15. Glycosylated hemoglobin A1c (HbA1c) has been applied to identify type 2 diabetes (T2DM) in the U.S. and European countries. It has not been used in China mainly due to lack of a standardized approach to measure H...

    Authors: Miao Mo, Weijian Zhong, Genming Zhao, Ye Ruan, Hua Zhang, Liang Shi, Dajiang Lu, Qundi Yang, Yanyun Li, Qingwu Jiang, Rui Li and Wang-Hong Xu
    Citation: BMC Endocrine Disorders 2013 13:44
  16. Traditional lipid indices have been associated with type 2 diabetes, but it remains uncertain which lipid index is the best discriminator for diabetes. In this study, we aimed to assess lipoproteins, tradition...

    Authors: Zhi-Hong Jian, Chia-Chi Lung, Pei-Chieh Ko, Yi-Hua Sun, Jing-Yang Huang, Chien-Chang Ho, Chia-Yo Ho, Yi-Chen Chiang, Chien-Jen Chen and Yung-Po Liaw
    Citation: BMC Endocrine Disorders 2013 13:42
  17. The detection of microvascular damage in type 1 diabetes is difficult and traditional investigations do not detect changes until they are well established. The purpose of this study was to investigate the comb...

    Authors: Sarah P M Hosking, Rani Bhatia, Patricia A Crock, Ian Wright, Marline L Squance and Glenn Reeves
    Citation: BMC Endocrine Disorders 2013 13:41
  18. Animal studies have shown that zinc intake has protective effects against type 2 diabetes, but few studies have been conducted to examine this relationship in humans. The aim of this study is to investigate if...

    Authors: Khanrin Phungamla Vashum, Mark McEvoy, Zumin Shi, Abul Hasnat Milton, Md Rafiqul Islam, David Sibbritt, Amanda Patterson, Julie Byles, Deborah Loxton and John Attia
    Citation: BMC Endocrine Disorders 2013 13:40
  19. A considerable interest has been drawn to potential protective effects of bilirubin against oxidative stress-related diseases. Smoking is known to be associated with lower concentrations of serum bilirubin, bu...

    Authors: Maya Tanaka, Sanjeev Budhathoki, Akie Hirata, Makiko Morita, Suminori Kono, Masahiro Adachi, Hisaya Kawate, Keizo Ohnaka and Ryoichi Takayanagi
    Citation: BMC Endocrine Disorders 2013 13:39
  20. Obesity is associated with insulin resistance, development of diabetes, and coronary heart disease. There is limited information on the contribution of previous obesity on the risk of coronary heart disease. W...

    Authors: Ritsuko Yamamoto-Honda, Hideki Ehara, Hiroji Kitazato, Yoshihiko Takahashi, Shoji Kawazu, Yasuo Akanuma and Mitsuhiko Noda
    Citation: BMC Endocrine Disorders 2013 13:38
  21. To examine the effects of physical activity on the development and progression of microvascular complications in patients with type 1 diabetes.

    Authors: Caroline BT Makura, Krishnarajah Nirantharakumar, Alan J Girling, Ponnusamy Saravanan and Parth Narendran
    Citation: BMC Endocrine Disorders 2013 13:37
  22. Our aim was to assess the associations between vitamin D (vitD) status, metabolic profile and polymorphisms in genes involved in the transport (Group-Component: GC) and the hydroxylation (NAD synthetase 1: NADSYN...

    Authors: Lydia Foucan, Fritz-Line Vélayoudom-Céphise, Laurent Larifla, Christophe Armand, Jacqueline Deloumeaux, Cedric Fagour, Jean Plumasseau, Marie-Line Portlis, Longjian Liu, Fabrice Bonnet and Jacques Ducros
    Citation: BMC Endocrine Disorders 2013 13:36
  23. Ghrelin and peptide YY (PYY) are appetite regulating hormones secreted from the gastrointestinal tract (gut). Aside from their known effect on energy homeostasis, accumulating data indicates that these gut hor...

    Authors: Peyvand Amini, Farrell Cahill, Danny Wadden, Yunqi Ji, Pardis Pedram, Sangeetha Vidyasankar, Yanqing Yi, Wayne Gulliver, Gary Paterno, Hongwei Zhang, Alecia Rideout and Guang Sun
    Citation: BMC Endocrine Disorders 2013 13:35
  24. Alterations in the naive T cell subpopulations have been demonstrated in patients with T cell mediated autoimmune disorders, reminiscent of immunological changes found in the elderly during immunosenescence, i...

    Authors: Martina Prelog, Jörn Schönlaub, Reinhard Würzner, Christian Koppelstaetter, Giovanni Almanzar, Andrea Brunner, Martin Gasser, Rupert Prommegger, Gabriele Häusler, Klaus Kapelari and Wolfgang Högler
    Citation: BMC Endocrine Disorders 2013 13:34
  25. Insufficient vitamin D status and increased renin-angiotensin system (RAS) activity have been associated with renal-vascular disease and nephropathy in diabetes. Accumulating evidence indicates that vitamin D ...

    Authors: Jenifer M Brown, Kristina Secinaro, Jonathan S Williams and Anand Vaidya
    Citation: BMC Endocrine Disorders 2013 13:33
  26. The interaction of advanced glycation end products (AGEs) and its receptor (RAGE) has played an important role in the pathogenesis of diabetes and its complications. A soluble form of RAGE (sRAGE) has been rep...

    Authors: Tarek MK Motawi, Mohamed A Abou-Seif, Ahmed MA Bader and Mohamed O Mahmoud
    Citation: BMC Endocrine Disorders 2013 13:32
  27. Sub-clinical hypothyroid dysfunction, a relatively understudied disorder in the Kingdom of Saudi Arabia (KSA), has significant clinical implications if not properly monitored. Also from KSA, more than 50% of t...

    Authors: Naji J Aljohani, Nasser M Al-Daghri, Omar S Al-Attas, Majed S Alokail, Khalid M Alkhrafy, Abdulaziz Al-Othman, Sobhy Yakout, Abdulaziz F Alkabba, Ahmed S Al-Ghamdi, Mussa Almalki, Badurudeen Mahmood Buhary and Shaun Sabico
    Citation: BMC Endocrine Disorders 2013 13:31
  28. To examine the association of anthropometry indices with gout and to compare the performance of indices to predict gout in Taiwanese men.

    Authors: Wen-Yu Lin, Chia-Chi Lung, Ting-Sung Liu, Zhi-Hong Jian, Pei-Chieh Ko, Jing-Yang Huang, Chien-Chang Ho, Shih-Chang Chen, Yi-Chen Chiang and Yung-Po Liaw
    Citation: BMC Endocrine Disorders 2013 13:30
  29. Sorafenib can be considered as the effective option of treatment in patients with metastatic radioiodine refractory differentiated thyroid cancers. The cutaneous manifestations of Sorafenib include rash, desqu...

    Authors: Syed Zubair Hussain, Ali Asghar, Mubasher Ikram and Najmul Islam
    Citation: BMC Endocrine Disorders 2013 13:29
  30. Being an intermediate stage in the development of diabetes, pre-diabetics were estimated as high as 14% to 63% in China and one to three quarters of them will develop into diabetes within 10 years. It is well ...

    Authors: Rui Feng, Kaichun Li, Jing Cheng, Shaoyu Xie, Jing Chai, Pingfu Wei and Debin Wang
    Citation: BMC Endocrine Disorders 2013 13:28
  31. Hypothyroidism, commonly induced in preparation for radioiodine treatment of differentiated thyroid cancer, is a text-book cause for hyponatremia. Nausea, stress, and increased fluid intake associated with the...

    Authors: Muhammad M Hammami, Fahad Almogbel, Sumaya Hammami, Jaber Faifi, Awad Alqahtani and Walid Hashem
    Citation: BMC Endocrine Disorders 2013 13:27
  32. The abnormality of interleukin-21 (IL-21)-IL-21-receptor (IL-21R) system has been found in many autoimmune diseases including autoimmune thyroid diseases (AITDs). In this study, we investigated whether polymor...

    Authors: Jian Zhang, Wan Xia Xiao, Yuan Feng Zhu, Fatuma Said Muhali, Ling Xiao, Wen Juan Jiang, Xiao Hong Shi, Lian Hua Zhou and Jin An Zhang
    Citation: BMC Endocrine Disorders 2013 13:26
  33. Diabetes distress is a general term that refers to the emotional burdens, anxieties, frustrations, stressors and worries that stem from managing a severe, complex condition like Type 1 diabetes. To date there ...

    Authors: Myles Balfe, Frank Doyle, Diarmuid Smith, Seamus Sreenan, Ruairi Brugha, David Hevey and Ronan Conroy
    Citation: BMC Endocrine Disorders 2013 13:25
  34. In randomized controlled trials (RCTs), colesevelam HCI, added to other anti-diabetic therapy, reduced hemoglobin A1C by approximately 0.3% to 0.4% over 16- to 26-weeks compared with an increase of approximate...

    Authors: Richard A Hansen, Joel F Farley, Matthew L Maciejewski, Xin Ye, Chunlin Qian and Ben Powers
    Citation: BMC Endocrine Disorders 2013 13:24
  35. Infection is the most common precipitating factor and cause of death in patients with hyperglycemic crises. Treating infection-precipitated hyperglycemic crises includes using empiric antibiotics early; correc...

    Authors: Chien-Cheng Huang, Willy Chou, Hung-Jung Lin, Shih-Chung Chen, Shu-Chun Kuo, Wei-Lung Chen, Jiann-Hwa Chen, Hsien-Yi Wang and How-Ran Guo
    Citation: BMC Endocrine Disorders 2013 13:23
  36. Down syndrome (DS) has been described as one of the main contributors for low bone mineral density (BMD). Physical activity (PA) is a key factor in skeletal health and thus, PA levels might be associated to th...

    Authors: Ángel Matute-Llorente, Alejandro González-Agüero, Alba Gómez-Cabello, Germán Vicente-Rodríguez and José Antonio Casajús
    Citation: BMC Endocrine Disorders 2013 13:22
  37. Chronic insulin resistance, exacerbated in the course of pregnancy, is an important pathophysiologic mechanism of gestational diabetes mellitus (GDM). We hypothesise that the degree of insulin resistance, asse...

    Authors: Alina Sokup, Barbara Ruszkowska-Ciastek, Krzysztof Góralczyk, Małgorzata Walentowicz, Marek Szymański and Danuta Rość
    Citation: BMC Endocrine Disorders 2013 13:21
  38. Type 2 diabetes is a common and costly illness, associated with significant morbidity and mortality. Despite this, there is relatively little information on the ‘real-world’ medication utilization patterns for...

    Authors: Manjiri Pawaskar, Machaon Bonafede, Barbara Johnson, Robert Fowler, Gregory Lenhart and Byron Hoogwerf
    Citation: BMC Endocrine Disorders 2013 13:20
  39. Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a common cause of hyponatremia in hospitalized patients and is often described in patients with small-cell carcinoma of the lung. In this rep...

    Authors: Chong-Gui Zhu, Qiu-Zi Zhang, Mei Zhu, Qiong-Li Zhai, Xiao-Yu Liang, Zong-Hong Shao, Emily C Ver Hoeve and Hui-Qi Qu
    Citation: BMC Endocrine Disorders 2013 13:19
  40. The aim was to study the glycaemic control of type 2 diabetic patients, and to identify factors associated with unacceptable glycaemic control (defined as HbA1c >8.0%).

    Authors: Joanne Hui Min Quah, Yan Ping Liu, Nan Luo, Choon How How and Ee Guan Tay
    Citation: BMC Endocrine Disorders 2013 13:18
  41. Autoimmune thyroid diseases including Graves’ disease and Hashimoto’s thyroiditis are caused by immune response to self-thyroid antigens. The rare situation of hyperthyroidism with Graves’ disease in twins has...

    Authors: Christoph A Rüst, Beat Knechtle and Thomas Rosemann
    Citation: BMC Endocrine Disorders 2013 13:17
  42. Marine-Lenhart syndrome is defined as the co-occurrence of Graves’ disease and functional nodules. The vast majority of autonomous adenomas are benign, whereas functional thyroid carcinomas are considered to b...

    Authors: Thomas Scherer, Evelyne Wohlschlaeger-Krenn, Michaela Bayerle-Eder, Christian Passler, Angelika Reiner-Concin, Michael Krebs and Alois Gessl
    Citation: BMC Endocrine Disorders 2013 13:16
  43. This study compares annual ambulatory care expenditures per patient with type 2 diabetes mellitus (T2DM) in France according to treatment phase and renal function status.

    Authors: Florent Guelfucci, Emilie Clay, Samuel Aballéa, Régis Lassalle, Nicholas Moore and Mondher Toumi
    Citation: BMC Endocrine Disorders 2013 13:15
  44. Hypovitaminosis D is a common condition among elderly individuals in temperate-climate countries, with a clear seasonal variation on 25 hydroxyvitamin D [(25(OH)D] levels, increasing after summer and decreasin...

    Authors: Sergio Setsuo Maeda, Gabriela Luporini Saraiva, Ilda Sizue Kunii, Lilian Fukusima Hayashi, Maysa Seabra Cendoroglo, Luiz Roberto Ramos and Marise Lazaretti-Castro
    Citation: BMC Endocrine Disorders 2013 13:14
  45. HIV patients on HAART are prone to metabolic abnormalities, including insulin resistance, lipodystrophy and diabetes. This study purports to investigate the relationship of ethnicity and CD4+ T cell count atta...

    Authors: Ranjita Misra, Prakash Chandra, Steven E Riechman, Dustin M Long, Shivani Shinde, Henry J Pownall, Ivonne Coraza, Dorothy E Lewis, Rajagopal V Sekhar and Ashok Balasubramanyam
    Citation: BMC Endocrine Disorders 2013 13:13
  46. To investigate potential associations of serum prolactin concentration (PRL) with metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM), previously observed in small and selected study samples, in a la...

    Authors: Lisa Balbach, Henri Wallaschofski, Henry Völzke, Matthias Nauck, Marcus Dörr and Robin Haring
    Citation: BMC Endocrine Disorders 2013 13:12
  47. Osteocalcin (OC) is a bone-specific protein produced primarily by osteoblasts during bone formation. Besides its role in bone formation, osteocalcin may play a role in the regulation of energy metabolism and m...

    Authors: Anke Hannemann, Nele Friedrich, Christin Spielhagen, Rainer Rettig, Till Ittermann, Matthias Nauck and Henri Wallaschofski
    Citation: BMC Endocrine Disorders 2013 13:11
  48. The editors of BMC Endocrine Disorders would like to thank all our reviewers who have contributed to the journal in Volume 12 (2012).

    Authors: Tim Shipley
    Citation: BMC Endocrine Disorders 2013 13:6
  49. Diabetic patients with positive glutamic acid decarboxylase antibody (GAD-Ab) could be classified as autoimmune diabetes, which is discriminated into acute-onset classical type 1 diabetes (T1DM) and latent aut...

    Authors: Xia Li, Gan Huang, Jian Lin, Lin Yang and Zhiguang Zhou
    Citation: BMC Endocrine Disorders 2013 13:10

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