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  1. Subclinical hypothyroidism is common in older people and its contribution to health and disease needs to be elucidated further. Observational and clinical trial data on the clinical effects of subclinical hypo...

    Authors: R. S. Du Puy, I. Postmus, D. J. Stott, M. R. Blum, R. K. E. Poortvliet, W. P. J. Den Elzen, R. P. Peeters, B. C. van Munster, B. H. R. Wolffenbuttel, R. G. J. Westendorp, P. M. Kearney, I. Ford, S. Kean, C. M. Messow, T. Watt, J. W. Jukema…
    Citation: BMC Endocrine Disorders 2018 18:67
  2. Insulin and insulin-like growth factor (IGF)-1 coupled with growth hormone helps control timing of sexual maturation. Mutations and variants in multiple genes are associated with development or reduced risk of...

    Authors: Hua-Pin Chang, Shun-Fa Yang, Shu-Li Wang and Pen-Hua Su
    Citation: BMC Endocrine Disorders 2018 18:66
  3. Metabolic syndrome (MetS) includes obesity, diabetes, dyslipidemia and hypertension. Its incidence is rapidly increasing worldwide, particularly in postmenopausal women. Estrogens regulate glucose homeostasis ...

    Authors: Lingxia Zhao, Xuemei Fan, Lin Zuo, Qiang Guo, Xiaole Su, Guangxia Xi, Ziyan Zhang, Jianlin Zhang and Guoping Zheng
    Citation: BMC Endocrine Disorders 2018 18:65
  4. To investigate the effect of a mildly elevated thyroid-stimulating hormone (TSH) concentration between 2.5 and 4.0 mIU/L during the first trimester on pregnancy outcomes in thyroid peroxydase antibody (TPOAb)-...

    Authors: Ping Li, Shuo Lin, Ling Li, Jinhui Cui, Shuisheng Zhou and Jianhui Fan
    Citation: BMC Endocrine Disorders 2018 18:64
  5. Type 2 diabetes is a serious clinical problem in both India and the UK. Adoption of a healthy lifestyle through dietary and physical activity modification can help prevent type 2 diabetes. However, implementin...

    Authors: Hazel Thomson, Nick Oliver, Ian F. Godsland, Ara Darzi, Weerachai Srivanichakorn, Azeem Majeed, Desmond G. Johnston, Arun Nanditha, Chamukuttan Snehalatha, Arun Raghavan, Priscilla Susairaj, Mary Simon, Krishnamoorthy Satheesh, Ambady Ramachandran, Stephen Sharp, Kate Westgate…
    Citation: BMC Endocrine Disorders 2018 18:63
  6. The aim of this study was to assess inadequate glycaemic control and its associated factors among people with type 2 diabetes in Saudi Arabia.

    Authors: Mohammed J. Alramadan, Dianna J. Magliano, Turky H. Almigbal, Mohammed Ali Batais, Afsana Afroz, Hesham J. Alramadhan, Waad Faozi Mahfoud, Adel Mehmas Alragas and Baki Billah
    Citation: BMC Endocrine Disorders 2018 18:62
  7. The aim of the present study is to evaluate the association between BMD and type 2 DM status in middle-aged and elderly men. To investigate a possible correlation, the present study used the BMD dataset of the...

    Authors: Miso Jang, Hyunkyung Kim, Shorry Lea, Sohee Oh, Jong Seung Kim and Bumjo Oh
    Citation: BMC Endocrine Disorders 2018 18:61
  8. Intestinal bacteria influence bone remodeling in rodents, and antibiotic manipulation of the rodent gut microbiota increases bone formation and prevents ovariectomy-induced bone loss. In theory, these effects ...

    Authors: Kristian H. Mikkelsen, Tina Vilsbøll, Jens J. Holst, Bolette Hartmann, Filip K. Knop and Morten Frost
    Citation: BMC Endocrine Disorders 2018 18:60
  9. Galactomannan(s) are plant-derived fiber shown to reduce post-prandial blood glucose by delaying intestinal absorption of carbohydrates and slowing down gastric emptying. We examined glucose-lowering effects o...

    Authors: Andrea O. Y. Luk, Benny C. Y. Zee, Marc Chong, Risa Ozaki, Carl W. Rausch, Michael H. M. Chan, Ronald C. W. Ma, Alice P. S. Kong, Francis C. C. Chow and Juliana C. N. Chan
    Citation: BMC Endocrine Disorders 2018 18:59
  10. Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases in children. Studies on costs related to T1DM are scarce and focused primarily on the costs directly related to diabetes. We aimed to ...

    Authors: E. A. J. M. Spaans, P. R. van Dijk, K. H. Groenier, P. L. P. Brand, N. Kleefstra and H. J. G. Bilo
    Citation: BMC Endocrine Disorders 2018 18:57
  11. The shapes of the plasma glucose concentration curve during the oral glucose tolerance test are related to different metabolic risk profiles and future risk of type 2 DM. We sought to further analyze the relat...

    Authors: Leonardo de Andrade Mesquita, Luciana Pavan Antoniolli, Giordano Fabricio Cittolin-Santos and Fernando Gerchman
    Citation: BMC Endocrine Disorders 2018 18:56
  12. Here we study the effect of type 2 diabetes (T2DM) on bone cell precursors, turnover and cytokines involved in the control of bone cell formation and activity.

    Authors: Francesca Sassi, Ilaria Buondonno, Chiara Luppi, Elena Spertino, Emanuela Stratta, Marco Di Stefano, Marco Ravazzoli, Gianluca Isaia, Marina Trento, Pietro Passera, Massimo Porta, Giovanni Carlo Isaia and Patrizia D’Amelio
    Citation: BMC Endocrine Disorders 2018 18:55
  13. To compare the accuracy of different obesity indexes, including waist circumference (WC), weight-to-height ratio (WHtR), body mass index (BMI), and lipid accumulation product (LAP), in predicting metabolic syn...

    Authors: Leilei Liu, Yu Liu, Xizhuo Sun, Zhaoxia Yin, Honghui Li, Kunpeng Deng, Xu Chen, Cheng Cheng, Xinping Luo, Ming Zhang, Linlin Li, Lu Zhang, Bingyuan Wang, Yongcheng Ren, Yang Zhao, Dechen Liu…
    Citation: BMC Endocrine Disorders 2018 18:54
  14. Diabetic foot ulceration is a serious limb-threatening complication of diabetes. It is the common cause of hospital admissions and amputations.

    Authors: Bilal Bin Younis, Adeela Shahid, Rozina Arshad, Saima Khurshid, Muhammad Ahmad and Haroon Yousaf
    Citation: BMC Endocrine Disorders 2018 18:53
  15. Type 2 Diabetes Mellitus is a serious metabolic disease that is often associated with vascular complications. There are 1.9 million people living with Diabetes in Ethiopia; diabetes mellitus is found to be the...

    Authors: Haileab Fekadu Wolde, Asrat Atsedeweyen, Addisu Jember, Tadesse Awoke, Malede Mequanent, Adino Tesfahun Tsegaye and Shitaye Alemu
    Citation: BMC Endocrine Disorders 2018 18:52
  16. The Ki-67 index in gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) may change throughout the disease course. However, the definitive effect of Ki-67 variability on GEP-NENs remains unknown. The aims...

    Authors: Huiying Shi, Qin Zhang, Chaoqun Han, Ding Zhen and Rong Lin
    Citation: BMC Endocrine Disorders 2018 18:51
  17. Diabetes in the United States has reached epidemic proportions and the people of Appalachia have been disproportionately affected by this disease. Strategies that complement standard diabetes care are critical...

    Authors: Elizabeth A. Beverly, Jane Hamel-Lambert, Laura L. Jensen, Sue Meeks and Anne Rubin
    Citation: BMC Endocrine Disorders 2018 18:50
  18. Glycaemic control is one of the most effective strategies for the treatment of diabetes-related erectile dysfunction (DMED). Compared to conventional anti-diabetic drugs and insulin, islet transplantation is m...

    Authors: Zhigang Wu, Hongwei Wang, Fubiao Ni, Xuan Jiang, Ziqiang Xu, Chengyang Liu, Yong Cai, Hongxing Fu, Jiao Luo, Wenwei Chen, Bicheng Chen and Zhixian Yu
    Citation: BMC Endocrine Disorders 2018 18:49
  19. Vitamin D deficiency is a common health problem. Vitamin D supplements are used to improve vitamin D status; however, there are contradictory data related to what doses to give and how often they should be giv...

    Authors: Mahmut Apaydin, Asli Gencay Can, Muhammed Kizilgul, Selvihan Beysel, Seyfullah Kan, Mustafa Caliskan, Taner Demirci, Ozgur Ozcelik, Mustafa Ozbek and Erman Cakal
    Citation: BMC Endocrine Disorders 2018 18:48
  20. Optimal glycaemia, reflected by glycated haemoglobin (HbA1c) levels, is key in reducing type 2 diabetes (T2D) complications. However, most people with T2D have suboptimal recall and understanding of HbA1c. Con...

    Authors: Mei Lyn Tan, Jo-Anne Manski-Nankervis, Sharmala Thuraisingam, Alicia Jenkins, David O’Neal and John Furler
    Citation: BMC Endocrine Disorders 2018 18:47
  21. Papillary thyroid carcinoma with pleomorphic tumor giant cells (PTC-PC) is characterized by the occurrence of bizarre, pleomorphic cells within a small area of a conventional PTC. The histologic distinction be...

    Authors: Johan O. Paulsson, Jan Zedenius and C. Christofer Juhlin
    Citation: BMC Endocrine Disorders 2018 18:46
  22. Incidence of dementia is growing rapidly and affects many people worldwide. Type 2 diabetes mellitus (DM) might link cognitive decline and dementia, but the reasons for this association remain unclear. Our stu...

    Authors: Chun-Lin Liu, Ming-Yen Lin, Shang-Jyh Hwang, Ching-Kuan Liu, Huei-Lan Lee and Ming-Tsang Wu
    Citation: BMC Endocrine Disorders 2018 18:45
  23. Vitamin D deficiency is pandemic while resources available to measure 25-hydroxyvitamin D (25OHD) are limited. The present study aimed to verify whether sun exposure measured by a structured questionnaire coul...

    Authors: Fernanda Barros Bittar, Charlles H. M. Castro and Vera Lúcia Szejnfeld
    Citation: BMC Endocrine Disorders 2018 18:44
  24. Diabetic foot is one of the most significant and devastating complication of diabetes. The objective of this study was to assess the prevalence of diabetic foot syndrome (DFS) and the associated risk factors a...

    Authors: S. P. Vibha, Muralidhar M. Kulkarni, A. B. Kirthinath Ballala, Asha Kamath and G. Arun Maiya
    Citation: BMC Endocrine Disorders 2018 18:43
  25. The benefit results of postoperative tight glycemic control (TGC) were controversial and there was a lack of well-powered studies that support current guideline recommendations.

    Authors: Yuan-yuan Wang, Shuang-fei Hu, Hui-min Ying, Long Chen, Hui-li Li, Fang Tian and Zhen-feng Zhou
    Citation: BMC Endocrine Disorders 2018 18:42
  26. Pheochromocytoma, especially for noncatecholamine-secreting pheochromocytoma, is an extremely rare cause of ectopic corticotrophin-releasing hormone (CRH) syndrome.

    Authors: Bao-Ping Wang, Lei-Lei Yang, Hao Wang, Qing He, Zhong-Shu Ma, Yi Lin, Chang-Xin Jiang, Hao-Ran Sun and Ming Liu
    Citation: BMC Endocrine Disorders 2018 18:41
  27. Obesity and diabetes mellitus, or diabetes, are independently associated with post-ischemic stroke outcomes (e.g., functional disability and all-cause mortality). Although obesity and diabetes are also associated...

    Authors: Colleen Bauza, Sharon D. Yeatts, Keith Borg, Gayenell Magwood, Renee’ H. Martin, Anbesaw Selassie and Marvella E. Ford
    Citation: BMC Endocrine Disorders 2018 18:40
  28. The prevalence of childhood obesity and obesity-related metabolic disorder such as dyslipidemia has sharply increased in the past few decades. Chronic low-grade inflammation is associated with the development ...

    Authors: Yuesheng Liu, Dong Xu, Chunyan Yin, Sisi Wang, Min Wang and Yanfeng Xiao
    Citation: BMC Endocrine Disorders 2018 18:39
  29. Testosterone signals through the androgen receptor (AR) and AR knockout mice develop obesity, suggesting a functional association between AR and leptin signaling. Furthermore, physiological blood concentration...

    Authors: Koichi Yabiku, Keiko Nakamoto and Akihiro Tokushige
    Citation: BMC Endocrine Disorders 2018 18:38
  30. Nivolumab, an anti-programmed cell death-1 monoclonal antibody, has improved the survival of patients with malignant melanoma. Despite its efficacy, nivolumab inconsistently induces thyroid dysfunction as an i...

    Authors: Seiichi Yano, Kenji Ashida, Hiromi Nagata, Kenji Ohe, Naoko Wada, Yukina Takeichi, Yuki Hanada, Yuta Ibayashi, Lixiang Wang, Shohei Sakamoto, Ryuichi Sakamoto, Hiroshi Uchi, Motoaki Shiratsuchi, Masutaka Furue, Masatoshi Nomura and Yoshihiro Ogawa
    Citation: BMC Endocrine Disorders 2018 18:36
  31. Hypoglycaemia is a feared experience for people with diabetes. We aimed to study the prevalence and causes of hypoglycaemia among Sri Lankans with diabetes.

    Authors: H. A. Dissanayake, G. S. P. Keerthisena, K. K. K. Gamage, J. H. Liyanage, I. R. H. S. Ihalagama, W. M. U. A. Wijetunga, T. A. D. Tillekaratne, G. W. Katulanda and P. Katulanda
    Citation: BMC Endocrine Disorders 2018 18:35
  32. Diabetes mellitus is one of the most prevalent diseases worldwide. Diabetes is a chronic disease associated with micro- and macro-vascular complications and deterioration in general health status. Therefore, t...

    Authors: Masoud Behzadifar, Rahim Sohrabi, Roghayeh Mohammadibakhsh, Morteza Salemi, Sharare Taheri Moghadam, Masood Taheri Mirghaedm, Meysam Behzadifar, Hamid Reza Baradaran and Nicola Luigi Bragazzi
    Citation: BMC Endocrine Disorders 2018 18:34
  33. Screening for risk of type 2 diabetes mellitus (T2DM) is an important public health issue. Previous studies report that fasting plasma glucose (FPG) and triglyceride (TG)-related indices, such as lipid accumul...

    Authors: Joung-Won Lee, Nam-Kyoo Lim and Hyun-Young Park
    Citation: BMC Endocrine Disorders 2018 18:33
  34. Diabetes mellitus is usually preceded by a pre-diabetic stage before the clinical presentation of the disease, the influence of which on persons’ quality of life is not adequately elucidated. The purpose of th...

    Authors: Konstantinos Makrilakis, Stavros Liatis, Afroditi Tsiakou, Chryssoula Stathi, Eleftheria Papachristoforou, Despoina Perrea, Nicholas Katsilambros, Nikolaos Kontodimopoulos and Dimitrios Niakas
    Citation: BMC Endocrine Disorders 2018 18:32
  35. There is evidence that disparities exist in diabetes prevalence, access to diabetes care, diabetes-related complications, and the quality of diabetes care. A wide range of interventions has been implemented an...

    Authors: Natalie Terens, Simona Vecchi, Anna Maria Bargagli, Nera Agabiti, Zuzana Mitrova, Laura Amato and Marina Davoli
    Citation: BMC Endocrine Disorders 2018 18:31
  36. This study aimed to detect changes in hormone levels in the hypothalamic–pituitary–ovarian axis in Sprague-Dawley (SD) rats with hypothyroidism, and identify differences in the pregnancy and abortion rates of ...

    Authors: Jianran Sun, Cancan Hui, Tongjia Xia, Min Xu, Datong Deng, Faming Pan and Youmin Wang
    Citation: BMC Endocrine Disorders 2018 18:30
  37. Thyroid hormones are known to have direct and indirect effects on metabolism. Individuals with metabolic syndrome, a disease that is growing in incidence at a rapid rate, are at higher risk for cardiovascular ...

    Authors: Jieun Jang, Youngsook Kim, Jaeyong Shin, Sang Ah Lee, Young Choi and Eun-Cheol Park
    Citation: BMC Endocrine Disorders 2018 18:29
  38. The diagnosis of atypical non-autoimmune forms of diabetes mellitus, such as maturity onset diabetes of the young (MODY) presents several challenges, in view of the extensive clinical and genetic heterogeneity...

    Authors: Nikolai Paul Pace, Johann Craus, Alex Felice and Josanne Vassallo
    Citation: BMC Endocrine Disorders 2018 18:28
  39. Cardiovascular disease (CVD) presents the most serious health problems and contributes to the increased mortality in young women with Turner syndrome. Arterial hypertension in Turner syndrome patients is signi...

    Authors: Ji Yeon Shin, Bo Hyun Kim, Young Keum Kim, Tae Hwa Kim, Eun Heui Kim, Min Jin Lee, Jong Ho Kim, Yun Kyung Jeon, Sang Soo Kim and In Joo Kim
    Citation: BMC Endocrine Disorders 2018 18:27
  40. Retinol binding protein 4 (RBP4), a protein secreted by adipocytes and bound in plasma to transthyretin (TTR), has been associated with obesity, the early phase of insulin resistance, metabolic syndrome, and t...

    Authors: Karunee Kwanbunjan, Pornpimol Panprathip, Chanchira Phosat, Noppanath Chumpathat, Naruemon Wechjakwen, Somchai Puduang, Ratchada Auyyuenyong, Ina Henkel and Florian J. Schweigert
    Citation: BMC Endocrine Disorders 2018 18:26
  41. Recent epidemiological studies have suggested inverse associations between vitamin D status and metabolic diseases including type 2 diabetes (T2DM). The aim of this study was to examine whether a higher serum ...

    Authors: Danting Li, Haoche Wei, Hongmei Xue, Jieyi Zhang, Mengxue Chen, Yunhui Gong and Guo Cheng
    Citation: BMC Endocrine Disorders 2018 18:25
  42. Cushing’s syndrome in humans shares many similarities with its counterpart in dogs in terms of etiology (pituitary versus adrenal causes), clinical signs, and pathophysiologic sequelae. In both species, treatm...

    Authors: Daniel K. Langlois, Michele C. Fritz, William D. Schall, N. Bari Olivier, Rebecca C. Smedley, Paul G. Pearson, Marc B. Bailie and Stephen W. Hunt III
    Citation: BMC Endocrine Disorders 2018 18:24
  43. 11β-Hydroxylase deficiency (11OHD) is a common form of congenital adrenal hyperplasia that has been shown to result from inactivating CYP11B1 mutations, and pathogenic CYP11B2/CYP11B1 chimeras contribute to a min...

    Authors: Lian Duan, Rufei Shen, Lingyu Song, Yong Liao and Hongting Zheng
    Citation: BMC Endocrine Disorders 2018 18:23
  44. Adrenocorticotropic hormone (ACTH)-independent Cushing’s syndrome (CS) with bilateral cortisol-secreting adenomas has been rarely reported in the literatures. Precise recognition and management of this disorde...

    Authors: Jia Wei, Sheyu Li, Qilin Liu, Yuchun Zhu, Nianwei Wu, Ying Tang, Qianrui Li, Kaiyun Ren, Qianying Zhang, Yerong Yu, Zhenmei An, Jing Chen and Jianwei Li
    Citation: BMC Endocrine Disorders 2018 18:22
  45. To our knowledge, no reports are available indicating the effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome (PC...

    Authors: Khadijeh Nasri, Mehri Jamilian, Elham Rahmani, Fereshteh Bahmani, Maryam Tajabadi-Ebrahimi and Zatollah Asemi
    Citation: BMC Endocrine Disorders 2018 18:21
  46. Growth hormone deficiency (GHD) is a potential consequence of traumatic brain injury (TBI), including sport-related concussion (SRC). GH stimulation testing is required for definitive diagnosis; however, this ...

    Authors: Kirstie Lithgow, Alex Chin, Chantel T. Debert and Gregory A. Kline
    Citation: BMC Endocrine Disorders 2018 18:20
  47. Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is caused by tumours releasing ACTH. Ectopic ACTH-producing tumour regression is rarely induced using steroidogenesis inhibitors. We presented a case o...

    Authors: Hideyuki Iwayama, Sho Hirase, Yuka Nomura, Tatsuo Ito, Hiroyuki Morita, Kazuo Otake, Akihisa Okumura and Junko Takagi
    Citation: BMC Endocrine Disorders 2018 18:19
  48. Here, we report a case of central pontine demyelinization in a type-2 diabetes patient with hyperglycemia after a binge-eating attack in the absence of a relevant hyponatremia.

    Authors: Rainer U. Pliquett, Arno Noll, Richard Ibe, Alexandra Katz, Charlotte Ackmann, Alexandra Schreiber and Matthias Girndt
    Citation: BMC Endocrine Disorders 2018 18:18

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