Skip to main content

Profile and factors associated with glycaemic control of patients with type 2 diabetes in Greece: results from the diabetes registry



Strict glycaemic control early in the treatment process has been shown to reduce the occurrence of micro- and macro- vascular complications of diabetes in the long-term. Thus, treatment guidelines advise early intensification of treatment to achieve glycaemic control goals. However, evidence in Greece suggests that, despite guideline recommendations, glycaemic control among patients with T2DM remains challenging. This study presents the demographic and clinical characteristics of patients with T2DM in Greece using data from an electronic registry designed specifically for this treatment category and investigates the factors that are independently associated with glycaemic control.


This is a multi-center, observational, cross-sectional study to investigate epidemiological and clinical factors affecting glycaemic control among patients with T2DM in Greece. Data was collected via a web-based disease registry, the Diabetes Registry, which operated from January 1st to December 31st, 2017. Five large specialized diabetes centers operating in Greek hospitals participated in the study.


Data for 1141 patients were retrieved (aged 63.02 ± 12.65 years, 56.9% male). Glycaemic control (Hb1Ac < 7%) was not achieved in 57.1% of patients. Factors independently associated with poor glycaemic control were: family history of diabetes [OR: 1.53, 95% CI: 1.06–2.23], BMI score between 25 to 30 [OR: 2.08, 95% CI: 1.05–4.13] or over 30 [OR: 2.12, 95% CI 1.12–4.07], elevated LDL levels [OR: 1.53, 95% 1.06–2.21] and low HDL levels [OR: 2.12, 95% CI: 1.44–3.12]. Lastly, use of injectable antidiabetic agents (in monotherapy or in combination) was less likely to be associated with poor glycaemic control versus treatment with combination of oral and injectable agents [OR: 0.50, 95% CI: 0.24–1.01]. This association was found to be marginally statistically significant.


Inadequate lipid control, family history of diabetes and presence of obesity (ΒΜΙ ≥ 30 kg/m2) were associated with poor glycaemic control among study sample, whereas use of injectable antidiabetic agents was less likely to be associated with poor glycaemic control. These findings indicate how complex optimal glycaemic control is, highlighting the need for tailored interventions in high-risk subpopulations with T2DM.

Peer Review reports


Diabetes Mellitus (DM), a metabolic disorder primarily characterized by hyperglycemia, has constituted one of the most critical challenges to health systems all over the world [1,2,3]. According to the 2017 IDF Diabetes Atlas, the global prevalence of DM was estimated at 8.4% in adults aged 18–99 years. It is also a major contributor to global mortality with 5 million deaths attributed to complications related to diabetes during that year [4]. Type 2 Diabetes Mellitus (T2DM) accounts for 90–95% of all cases of diabetes and is, therefore, the most common type of DM [5, 6]. Risk factors include genetic predisposition [7,8,9] and lifestyle factors, mainly obesity, [10] physical inactivity [11] and smoking [12, 13]. The global prevalence of T2DM is expected to increase in both developed and developing countries over the next decades [14, 15].

In Greece, the prevalence of T2DM has been the subject of various epidemiological studies. According to recent estimations based on real-world data, 694,357 patients received prescribed medication for T2DM in 2015, accounting for 6.8% of the country’s population [16]. Furthermore, according to another study in rural, urban and suburban Greek populations, T2DM was associated with age over 40 years, obesity (BMI ≥ 30), personal history of smoking in the past and low socioeconomic status [17]. The economic burden of the disease is equally high. A 2014 study estimated the annual cost of each patient with diabetes in Greece at €7111. The cost was significantly higher in patients with poor glycaemic control (hemoglobin A1c [HbA1c] > 7%). The largest contributor to disease cost were complications of diabetes and comorbidities [18].

Strict glycaemic control early in the treatment process has been shown to reduce the occurrence of micro- and macro- vascular complications of diabetes in the long-term [19,20,21,22]. Thus, treatment guidelines advise early intensification of treatment to achieve glycaemic control goals, as individualized for each patient [23]. However, evidence in Greece suggests that, despite guideline recommendations, glycaemic control among patients with T2DM remains challenging in both the trial setting and the real world [24, 25]. This was evident in a 2013 Greek study among 6631 randomly selected patients with T2DM of whom 59% were found not to have achieved the target goal of HbA1c < 7%. More specifically, 44.7% of patients had an HbA1c level of 7–7.9 and 14.3% had an HbA1c > 8% [26]. Equally, another 2015 study showed that adequate glycaemic control had not been achieved in 32.9% of patients treated in 25 primary care sites [27], whilst a later study (2017) confirmed that 42% of study patients had not achieved the HbA1c target of < 7% [28].

A disease registry integrates a variety of information such as demographic characteristics, laboratory test results, clinical data, comorbidities and follow-up information to gather valuable information on the trends and management of chronic diseases [29]. Diabetes registries have been used as a tool to assess the epidemiologic profile of patients with diabetes and the quality of specialist care provided in various medical centers [30].

In the present study, five major diabetes units operating in large, public hospitals enrolled patients in a web-based disease registry, designed and developed to prospectively monitor and report on key disease indicators. The main objective was to explore current epidemiologic trends of the disease in Greece. Data regarding patient characteristics, co-morbidities and glycaemic control of participants were also collected. In addition, the study explored factors affecting the degree of glycaemic control among patient population to further recognize patient groups in need of intensive monitoring.


Sample and setting

This was a multi-center, cross-sectional observational study conducted in Greece. Participating centers were chosen as follows: out of 13 operating specialized diabetes centers in Attica, Piraeus, Macedonia and Thrace regions [31], six were contacted based on their special interest in diabetes research and their large geographic population coverage. Five out of six participated in the study. Study sample was comprised of patients with T2DM, both treatment naïve and treatment experienced, receiving diabetes treatment in these five participating centers.

All outpatient subjects, who were older than 18 years, diagnosed with T2DM and scheduled for a routine office visit during the time period between January 2017 and December 2017, were eligible to participate. Diagnosis of T2DM was based on the criteria proposed by World Health Organization (WHO) [32]. Patients were recruited on their first consultation in the study period (index visit). Additional data were also collected during follow up consultations, if patients visited the centers more than once during the study period.


All eligible patients signed informed consent forms prior to enrolment. The study was approved by the Research Committee board of the University of Peloponnese.

Research tool

All data was collected with the use of a web-based diabetes registry that was specifically designed and developed to support this study. The Diabetes Registry was developed through a collaboration of the University of Peloponnese and the Medical School of the University of Athens. The research tool used was developed on the basis of international best practice, published, disease risk indices [33, 34] as validated by expert clinicians on the field. The registry database was maintained on a dedicated, secure, fully encrypted server in the University of Peloponnese. All and any data exchanges were fully encrypted. Access was provided to one researcher, a medical expert, in each participating diabetes center. A separate electronic medical file was created for each eligible patient on day 0. At every follow up visit, the patient file was re-accessed and follow-up information was uploaded. This information included recent lab results, changes in pharmacological treatment and any new events or hospitalizations. This analysis reports on information recorded during the first patient visit only.

The registry recorded:

  • Demographic characteristics: Gender, age, educational level, place of residence, family and employment status.

  • Clinical characteristics: Duration and family history of T2DM (a patient was defined as having family history of diabetes if one or both of his/her parents or/and any of his/her siblings were diagnosed with T2DM, at any time in the past), treatment modalities, presence of established main comorbidities (macro-vascular disorders), severe risk factors for Cardiovascular disorders (CVD) (hypertension, dyslipidemia or both), metabolic disorders (hypothyroidism and hyperthyroidism) and diabetes related complications (retinopathy, diabetic foot, erectile dysfunction and peripheral neuropathy). Presence of concomitant diseases was self-reported. Data regarding Body Mass Index (BMI) and waist circumference were also recorded. Patients were categorized based on their BMI score as follows: participants with BMI score less than 25 kg/m2 were defined as normal and with BMI score between 25 kg/m2 and 30 kg/m2 as overweight. Patients with obesity were defined as having BMI score equal/over 30 kg/m2. Waist circumference target was set at 80 cm for women and 90 cm for men.

  • Laboratory test results: Levels of HbA1c, blood pressure (BP), high-density lipoprotein (HDL), low density lipoprotein (LDL), triglycerides (TG) and estimated Glomerular Filtration Rate (e-GFR) were assessed. EPI equation was used for the calculation of e-GFR. Glycaemic control was defined as adequate if HbA1c was less than 7%. Only patients who had a recent (during the last 12 months) laboratory test for HbA1c were included. For BP control target was set at less than 130/80 mm/Hg. Regarding lipid control, HDL levels of more than 40 mg/dl, LDL levels of less than 100 mg/dl and TG levels of less than 150 mg/dl were set as optimal. Participants were classified as having dyslipidemia if their serum lipids levels were other than optimal as described above and/or if they were on treatment with lipid lowering medications. Moreover, participants were classified as suffering from hypertension if they reported a previous diagnosis of hypertension or/and were receiving anti-hypertensive medication.

  • Lifestyle behaviors: Alcohol and tobacco consumption, physical activity and dietary habits were recorded. The dietary and physical activity factors were selected from the Diabetes Prevention toolkit [33, 34]. Item selection was based on their clinical importance for the pertinent disease category, as defined by the clinical experts who collaborated in the development of the registry

The diabetes registry was piloted to 100 patients to assess its validity. Pilot study results were evaluated by a group of experts. Patients who participated in the pilot study were excluded from the final analysis.

Statistical analysis

A descriptive and inferential analysis was performed on study data. Absolute and relative frequencies were used to describe categorical variables. Continuous variables were expressed using mean ± SD if normally distributed. Kolmogorov Smirnov criterion was used to test the normality of distributions.

All socio-demographic and clinical characteristics, laboratory measurements and lifestyle behaviors were univariately associated with glycaemic control (a cut-off point of HbA1c ≥ 7% was used). Patients diagnosed 6 or less months ago were excluded from further analyses. Chi-square tests were performed to test the association amongst categorical variables and independent t-test criterion was used to test for the association between a continuous and a categorical variable. All variables that yield statistically significance at the 5% level were entered into a multiple logistic regression model. Age, sex, BMI and duration of T2DM were entered into the final model as these are factors of pertinent clinical importance to this disease area and were considered to act as confounders. Adjusted Odds Ratios (OR) along with 95% Confidence Intervals and p-values are presented. All statistical analyses were conducted using SPSS v. 25 (Armonk, NY: IBM Corp.).


Demographic and clinical characteristics

Study population consisted of 1141 patients with T2DM. Mean age was 63.02 ± 12.65 years. Most of the patients were male (56.9%), living in urban areas (95.8%), had completed mandatory education (77.5%) and were economically inactive (i.e. pensioners or students) at the time of the study (63.5%). 81.1% were married and almost half (45.4%) of them had children. Participants’ socio-demographic characteristics are presented in Table 1.

Table 1 Demographic characteristics

Most patients had a T2DM diagnosis for more than 10 years (40.7%) and were categorized as obese based on their Body Mass Index score (BMI > 30; 61.8%). The majority of patients were on oral antidiabetic agents only (67.7%) and used 1 antidiabetic agent (66.3%). Family history of diabetes was reported by almost 1 in 2 participants (48.6%).

61.5 and 58.9% out of total study sample reported previous diagnosis of dyslipidemia and hypertension, respectively. Moreover, 43.6% of sample reported suffering from both of these conditions. 247 (21.6%) patients had a personal history of coronary artery disease, defined as stable or unstable angina, NSTEMI or STEMI. 94 (8.2%) had been diagnosed with heart failure. 53 (4.6%) had suffered from an ischemic or hemorrhagic stroke and another 50 (4.4%) from a transient ischemic attack (TIA). Hypothyroidism was present in 182 (16%) of the patients, while hyperthyroidism in 21 (1.8%). Sample’s clinical characteristics are presented in detail in Table 2.

Table 2 Clinical Characteristics and presence of comorbidities

Lifestyle behaviors

Almost 1 in 3 patients were smoking and 1 in 5 had ceased smoking during the last 12 months (20.5%). Only 14.7% of total sample had been engaging in a physical activity for at least 30 min per day or 3 times per week. The vast majority of participants did not follow a nutritious diet, as only 10.9 and 13.5% of responders reported consuming 3 or more servings of whole grain cereals daily and vegetable oil most of the days, respectively. Almost one in two (47.8%) reported daily consumption of 3 servings of processed starch. Only 9.7% of study participants reported drinking one or more alcoholic drinks per day, with the majority consuming zero alcohol on a daily basis (Table 3).

Table 3 Sample’s lifestyle behaviors

Glycaemic control

Poor glycaemic control was assessed using an HbA1c threshold of 7%. One hundred nine patients with less than 6 months with a T2DM diagnosis were excluded from this analysis so as not to influence the results. Seven hundred fifty-five out of the total sample had a recent (during the last 12 months) HbA1c measurement. Only 42.9% of patients assessed achieved HbA1c levels of less than 7%.

Univariate analyses showed that poor glycaemic control was associated with family history of diabetes (p = 0.045) and the type of pharmacological treatment (p = 0.010). In addition, the following laboratory measurements were found to be associated with glycaemic control: LDL (p = 0.047), HDL (p < 0.001) and TG (p < 0.001) (Table 4).

Table 4 Socio-demographic and clinical factors associated with glycaemic control

Factors independently associated with poor glycaemic control in our sample are depicted in Table 5. After adjusting for all other variables in the model, the following factors were found to be independently associated with poor glycaemic control: family history of diabetes [OR: 1.53, 95% CI: 1.06–2.23], BMI score between 25 to 30 kg/m2 [OR: 2.08, 95% CI: 1.05–4.13] or over 30 kg/m2 [OR: 2.14, 95% CI 1.12–4.07], elevated LDL levels [OR: 1.53, 95% 1.06–2.21] and low HDL levels [OR: 2.12, 95% CI: 1.44–3.12]. Lastly, use of injectable antidiabetic agents was less likely to be associated with poor glycaemic control versus the reference category [OR: 0.50, 95% CI: 0.24–1.01]. The former association was found to be marginally statistically significant.

Table 5 Multiple logistic Regression: Factors influencing glycaemic control (N = 591)


The present study investigated the demographic and clinical characteristics of patients with T2DM in Greece and the level of their glycaemic control. It enrolled 1141 patients and used a dedicated web-based registry to collect data from five specialized diabetes centers operating within Greek hospitals.

57.1% of patients registered and assessed were not achieving the goal of HbA1c < 7% during the study period. This is in accordance with previous Greek and global studies reporting that even though treatment guidelines suggest a rapid progression in the therapeutic algorithm to achieve good glycaemic control [23], the percentage of patients achieving the target HbA1c score remains low [26,27,28]. In particular, in the PANORAMA study Greek results it was estimated that 33% of 375 patients recorded an HbA1c level above 7% in the index visit [27]. The percentage of patients not achieving glycaemic control in a recent national study was equal to 47% [35].

In the univariate analysis, poor glycaemic control was associated with the type of pharmacological treatment. Those receiving oral medication, or a combination of oral and injectable treatment were less likely to be controlled than those receiving injectable treatment only. In the multivariate analysis, results have been adjusted by duration of treatment. Consequently, this variable cannot be the single explanation of the observed association. A previous study reported that injectable treatment with or without oral medications was associated with worse glycaemic control compared to diet and exercise alone [36] Moreover, Liatis et al., [35] indicated that patients treated with insulin tend to have worse levels of glycaemic control due to insulin being prescribed in latest stages of the disease. A possible explanation may be that the effect of GLP-1RA based-therapies mediates the relationship between injectable treatments and glycaemic control found in our study. It is also interesting that previous studies have reported the complexity of pharmaceutical treatment as a predictor of poor glycaemic control, with patients receiving more than 5 medications recording worse glycaemic control [36, 37].

Poor glycaemic control was independently associated with a higher BMI. Patients with BMI higher than 25 had a 2-fold higher risk for poor glycaemic control. A previous study among insulin-receiving patients with T2DM has associated lower BMI with worse glycaemic control [38]. The variability of these results may be explained by the multifactorial pathogenetic pathways of T2DM resulting in a smaller significance of personal physical factors in the overall management of the disease.

Further, better glycaemic control was observed in patients with a better lipid profile. High HDL levels and low LDL levels were independently associated with an HbA1c level < 7 [39]. This can be explained by the nature of the disease, affecting multiple metabolic pathways. The inverse association between HDL-C and HbA1c may be due to the rise in TGs in poorly controlled patients, which in turn, are inversely correlated to HDL-C. Hence, low HDL-C in poorly controlled patients may be the consequence of hyperglycemia rather than a causative factor. These patients constitute a high-risk group that should be managed properly to reduce the risk of CV risk and mortality [40].

Contrary to past studies, there was no statistically significant association between duration of treatment and glycaemic control. The duration of treatment has been reported as a predictor of poor glycaemic control in a number of previous studies [24, 37,38,39,40]. Moreover, no association between poor glycaemic control and age was confirmed. However, past studies have reported an association of younger age in patients with T2DM with poor glycaemic control, especially in patients younger than 40 years of age [24, 37,38,39,40,41]. The lack of statistical significance in this association in the present study may be attributed to the relatively small percentage of patients in this age group.

This analysis was performed on the HbA1c level recorded during the first visit of the study period. In patients, in whom the last HbA1 measurement was recorded outside the study period, this information was missing. Therefore, these patients were excluded from the assessment of their glycaemic control.

High prevalence of risk factors for CVD were confirmed among the study population. 61.5% of study population suffered from dyslipidemia and 58.9% from hypertension. These findings are in line with the existing literature, which has reported an even higher prevalence of these conditions in the diabetic population in both national and international settings. More specifically, in the population of the Diabetes Collaborative Registry, the prevalence of hypertension was estimated at 76.3% and of dyslipidemia at 70.7% [30], whereas Akhter et al., [42] estimated hypertension and dyslipidemia rates at 55.5% και 41.3%, respectively in a total of 876 patients. Moreover, among the Greek subgroup of the PANORAMA study hypertension criteria were met by 30.2% of the sample [27].

A very high prevalence of other established comorbidities was also reported among study population. 21.6% was reported as having Coronary Artery Disease and 8.2% heart failure. Those results are consistent with other large epidemiological studies that report a high prevalence of heart disease among patients with T2DM. In a recent Greek study, the prevalence of self-reported heart disease among patients with T2DM was 24% [43]. Additionally, the presence of stroke or transient ischemic attach was reported among 4.6 and 4.4% of sample respectively. Patients in the group of already established cardiovascular disease are the primary target for interventions aiming to reduce overall CV risk. It is interesting to investigate the treatment approach in this category of patients and the adherence to newer treatment guidelines specifically targeted at this group [23].

On the other hand, known CV risk factors were very common among study population, with active smoking recorded in 31.7% and lack of physical activity in 85.3% of sample. Therefore, this study confirms the urgency for a multi-systematic approach regarding the management of all patients with T2DM to reduce high morbidity and mortality associated with each CV event [44].

This study included multiple centers and used a standardized web-based registry to collect data. This standardized approach to data collection reduces variability in data management among different centers and facilitates real-time data monitoring, during each patient visit, thus reducing the effect of recall bias.

This study was limited by the fact that laboratory results were recorded by different laboratories in each participating hospital. This may have resulted in high variability, especially in the measurement of specific parameters, such as HbA1c, where the method of measurement is critical. Another limitation is that patients enrolled in this study were treated in specialized diabetes centers operating in large hospitals. These patients are expected to be more challenging, with a higher prevalence of comorbidities and complications than those treated in smaller units or primary care facilities. Participating centers were solely specialized diabetes clinics operating in large urban areas. Therefore study findings should be generalized with caution in the national setting, as variations in patient characteristics and management may exist.


Prevalence of risk factors for CVD and other comorbidities deemed high among the study population. Furthermore, a small proportion of the sample was engaged in healthy lifestyle behaviors. Inadequate lipid control, family history of diabetes and presence of obesity (ΒΜΙ ≥ 30 kg/m2) were associated with poor glycaemic control among study sample, whereas use of injectable antidiabetic agents was less likely to be associated with poor glycaemic control. These findings indicate how complex optimal management for patients with T2DM is, highlighting the need for tailored interventions in high-risk subpopulations with T2DM.

Availability of data and materials

The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.



Body mass index


Blood pressure


Chronic kidney disease


Cardiovascular disorders


Diabetes mellitus


Estimated glomerular filtration rate


Hemoglobin A1c


High-density lipoprotein


Low density lipoprotein


Type 2 diabetes mellitus




Transient ischemic attack


World Health Organization


  1. 1.

    Chatterjee S, Khunti K, Davies M. Type 2 diabetes. Lancet. 2017;389(10085):2239–51.

    CAS  Article  PubMed  Google Scholar 

  2. 2.

    Zheng Y, Ley S, Hu F. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol. 2017;14(2):88–98.

    Article  PubMed  Google Scholar 

  3. 3.

    Chen L, Magliano D, Zimmet P. The worldwide epidemiology of type 2 diabetes mellitus—present and future perspectives. Nat Rev Endocrinol. 2011;8(4):228–36.

    CAS  Article  PubMed  Google Scholar 

  4. 4.

    Ogurtsova K, da Rocha FJ, Huang Y, et al. IDF diabetes atlas: global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract. 2017;128:40–50.

    CAS  Article  PubMed  Google Scholar 

  5. 5.

    Tripathi B, Srivastava A. Diabetes mellitus: complications and therapeutics. Med Sci Monit. 2006;12(7):130–47.

    Google Scholar 

  6. 6.

    Zimmet P, Magliano D, Herman W, Shaw J. Diabetes: a 21st century challenge. Lancet Diab Endocrinol. 2014;2(1):56–64.

    Article  Google Scholar 

  7. 7.

    Merino J, Udler M, Leong A, Meigs J. A Decade of Genetic and Metabolomic Contributions to Type 2 Diabetes Risk Prediction. Curr Diab Rep. 2017;17(12).

  8. 8.

    Stančáková A, Laakso M. Genetics of type 2 diabetes. Endocr Dev. 2016;31:203–20.

    CAS  Article  PubMed  Google Scholar 

  9. 9.

    Gaulton K. Mechanisms of Type 2 Diabetes Risk Loci. Curr Diab Rep. 2017;17(9).

  10. 10.

    Haffner S. Relationship of metabolic risk factors and development of cardiovascular disease and diabetes. Obesity. 2006;14(6s):121S–7S.

    Article  PubMed  Google Scholar 

  11. 11.

    Eaton S, Eaton S. Physical inactivity, obesity, and type 2 diabetes: an evolutionary perspective. Res Q Exerc Sport. 2017;88(1):1–8.

    Article  PubMed  Google Scholar 

  12. 12.

    Maddatu J, Anderson-Baucum E, Evans-Molina C. Smoking and the risk of type 2 diabetes. Transl Res. 2017;184:101–7.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  13. 13.

    Wu Y, Ding Y, Tanaka Y, Zhang W. Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention. Int J Med Sci. 2014;11:1185–200.

    Article  PubMed  PubMed Central  Google Scholar 

  14. 14.

    Herman W, Zimmet P. Type 2 diabetes: an epidemic requiring global attention and urgent action. Diabetes Care. 2012;35(5):943–4.

    Article  PubMed  PubMed Central  Google Scholar 

  15. 15.

    Unnikrishnan R, Pradeepa R, Joshi S, Mohan V. Type 2 diabetes: demystifying the global epidemic. Diabetes. 2017;66(6):1432–42.

    CAS  Article  PubMed  Google Scholar 

  16. 16.

    Liatis S, Dafoulas G, Kani C, et al. The prevalence and treatment patterns of diabetes in the Greek population based on real-world data from the nation-wide prescription database. Diabetes Res Clin Pract. 2016;118:162–7.

    Article  PubMed  Google Scholar 

  17. 17.

    Tentolouris N, Andrianakos A, Karanikolas G, et al. Type 2 diabetes mellitus is associated with obesity, smoking and low socioeconomic status in large and representative samples of rural, urban, and suburban adult Greek populations. Hormones (Athens). 2012;11(4):458–67.

    Article  Google Scholar 

  18. 18.

    Migdalis I, Rombopoulos G, Hatzikou M, Manes C, Kypraios N, Tentolouris N. The cost of managing type 2 diabetes mellitus in Greece: a retrospective analysis of 10-year patient level data “the HERCULES study”. Int J Endocrinol. 2015;2015:520759.

    PubMed  PubMed Central  Google Scholar 

  19. 19.

    Intensive Diabetes Treatment and Cardiovascular Outcomes in Type 1 Diabetes: The DCCT/EDIC Study 30-Year Follow-up. Diabetes Care. 2016, 39(5):686–693. doi:

  20. 20.

    Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). The Lancet. 1998, 352(9131):837–853. doi:

  21. 21.

    Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). The Lancet. 1998, 352(9131):854–865. doi:

  22. 22.

    Holman R, Paul S, Bethel A. Ten-year follow-up of intensive glucose control in type 2 diabetes. J Vasc Surg. 2009;49(1):272.

    Article  Google Scholar 

  23. 23.

    Davies M, D’Alessio D, Fradkin J, et al. Management of Hyperglycemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of diabetes (EASD). Diabetes Care. 2018;41(12):2669–701.

    Article  PubMed  PubMed Central  Google Scholar 

  24. 24.

    Cheng LJ, Wang W, Lim ST, Wu VX. Factors associated with glycaemic control in patients with diabetes mellitus: a systematic literature review. J Clin Nurs. 2019;8(9–10):1433–50.

    Article  Google Scholar 

  25. 25.

    Mannucci E, Monami M, Dicembrini I, Piselli A, Porta M. Achieving HbA1c targets in clinical trials and in the real world: a systematic review and meta-analysis. J Endocrinol Investig. 2014;37(5):477–95.

    CAS  Article  Google Scholar 

  26. 26.

    Rombopoulos G, Hatzikou M, Latsou D, Yfantopoulos J. The prevalence of hypoglycemia and its impact on the quality of life (QoL) of type 2 diabetes mellitus patients (The HYPO Study). Hormones. 2013;12(4):550–8.

    Article  PubMed  Google Scholar 

  27. 27.

    Avramopoulos I, Moulis A, Nikas N. Glycaemic control, treatment satisfaction and quality of life in type 2 diabetes patients in Greece: the PANORAMA study Greek results. World J Diabetes. 2015;6(1):208–16.

    Article  Google Scholar 

  28. 28.

    Pagkalos E, Thanopoulou A, Sampanis C, et al. The real-life effectiveness and care patterns of type 2 diabetes Management in Greece. Exp Clin Endocrinol Diabetes. 2017;126(01):53–60.

    CAS  Article  PubMed  Google Scholar 

  29. 29.

    Han W, Sharman R, Heider A, Maloney N, Yang M, Singh R. Impact of electronic diabetes registry ‘Meaningful Use’ on quality of care and hospital utilization. J Am Med Inform Assoc. 2016;23(2):242–7.

    Article  Google Scholar 

  30. 30.

    Arnold S, Goyal A, Inzucchi S, et al. Quality of Care of the Initial Patient Cohort of the Diabetes Collaborative Registry ®. J Am Heart Assoc. 2017;6(8).

  31. 31.

    Ministry of Health. Specialized units and clinics. Published 2019. Accessed June 25, 2019.

  32. 32.

    World Health Organization. Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia. Geneva: WHO Document Production Services; 2006. Accessed 7 Mar 2019

    Google Scholar 

  33. 33.

    Harvard School of Public Health. Healthy Eating Plate. The Nutrition Source. Published 2019. Accessed 26 June 2019.

  34. 34.

    Harvard School of Public Health. Simple Steps to Preventing Diabetes. The Nutrition Source. Published 2019. Accessed 26 June 2019.

  35. 35.

    Liatis S, Iraklianou S, Kazakos K, et al. A Greek registry of current type 2 diabetes management, aiming to determine core clinical approaches, patterns and strategies. BMC Endocr Disord. 2019;19(1).

  36. 36.

    de Pablos-Velasco P, Parhofer K, Bradley C, et al. Current level of glycaemic control and its associated factors in patients with type 2 diabetes across Europe: data from the PANORAMA study. Clin Endocrinol. 2013;80(1):47–56.

    CAS  Article  Google Scholar 

  37. 37.

    Juarez DT, Sentell T, Tokumaru S, Goo R, Davis JW, Mau MM. Factors associated with poor glycemic control or wide glycemic variability among diabetes patients in Hawaii, 2006-2009. Prev Chronic Dis. 2012;9:120065.

    Article  Google Scholar 

  38. 38.

    Nichols GA, Hillier TA, Javor K, Brown JB. Predictors of glycemic control in insulin-using adults with type 2 diabetes. Diabetes Care. 2000;23(3):273–7.

    CAS  Article  Google Scholar 

  39. 39.

    Ali MK, Bullard KM, Saaddine JB, Cowie CC, Imperatore G, Gregg EW. Achievement of goals in U.S. diabetes care, 1999–2010. N Engl J Med. 2013;368(17):1613–24 34.

    CAS  Article  Google Scholar 

  40. 40.

    Dake A, Sora N. Diabetic dyslipidemia review: an update on current concepts and management guidelines of diabetic dyslipidemia. Am J Med Sci. 2016;351(4):361–5.

    Article  PubMed  Google Scholar 

  41. 41.

    Shamshirgaran SM, Mamaghanian A, Aliasgarzadeh A, Aiminisani N, Iranparvar-alamdari M, Ataie J. Age differences in diabetes-related complications and glycemic control. BMC Endocr Disord. 2017;17(1):25 36.

    Article  Google Scholar 

  42. 42.

    Akhter J, Ahmed A, Mawani M, Lakhani L, Kalsekar A, Tabassum S, Islam N. Patterns, control and complications of diabetes from a hospital based registry established in a low income country. BMC Endocr Disord. 2017;17(1):30.

  43. 43.

    Tentolouris A, Eleftheriadou I, Athanasakis K, et al. Prevalence of diabetes mellitus as well as cardiac and other main comorbidities in a representative sample of the adult Greek population in comparison with the general population. Hellenic J Cardiol. 2018.

  44. 44.

    Ford ES, Ajani UA, Croft JB, et al. Explaining the decrease in U.S. deaths from coronary disease, 1980-2000. N Engl J Med. 2007;356(23):2388–98.

    CAS  Article  Google Scholar 

Download references




This work was supported by an unrestricted research grant from Novo Nordisk Hellas. The funding body had no role in the design of the study, data collection and analysis, interpretation of the data and in writing the manuscript.

Author information




KS conceived the study, participated in study design, interpretation of the results and writing of the manuscript. AK participated in study design, data collection, interpretation of the results and writing of the manuscript. CG participated in study design and writing of the manuscript. GV, SN participated in data analysis, results interpretation and writing of the manuscript. EH, KK, AM, NT supervised data collection in one diabetes center, participated in interpretation of the results and critically revised the final version of the manuscript. TK, AP, ES participated in data collection and reviewed the draft manuscript. AS supervised data collection in one diabetes center, participated in study design, results interpretation and critically revised the final version of the manuscript. All authors read and approved the final version of the manuscript.

Corresponding author

Correspondence to Kyriakos Souliotis.

Ethics declarations

Ethics approval and consent to participate

The research protocol had achieved approval by the Research Committee board of the University of Peloponnese, in accordance with the ethical standards delineated in 1964 Declaration of Helsinki. All participants provided informed consent for their participation.

Consent for publication

Not applicable since all data are anonymized.

Competing interests

The authors declare that they have no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Souliotis, K., Koutsovasilis, A., Vatheia, G. et al. Profile and factors associated with glycaemic control of patients with type 2 diabetes in Greece: results from the diabetes registry. BMC Endocr Disord 20, 16 (2020).

Download citation


  • Type 2 diabetes mellitus
  • Glycaemic control
  • Registry
  • Profile