Clifford KS, MacDonald MJ: Survey of mRNAs encoding zinc transporters and other metal complexes from birth to adulthood: similar patterns in the Spraque-Dawley and Wistar BB Strains. Diabetes Research Clinical Practice. 2000, 49: 77-85. 10.1016/S0168-8227(00)00141-8.
Article
CAS
PubMed
Google Scholar
Chausmer AB: Zinc, insulin and diabetes. Journal of the American College of Nutrition. 1998, 17: 109-115.
Article
CAS
PubMed
Google Scholar
Vallee BL, Falchuk KH: The biochemical basis of zinc physiology. Physiological Reviews. 1993, 73: 9-118.
Google Scholar
Kim BJ, Kim YH, Kim S, Kim JW, Koh JY, Oh SH, Lee MK, Kim KW, Lee MS: Zinc as a paracrine effector in pancreatic islet cell death. Diabetes. 2000, 49: 367-372. 10.2337/diabetes.49.3.367.
Article
CAS
PubMed
Google Scholar
Ishihara H, Maechler P, Gjinovci A, Herrera PL, Wollheim CB: Islet β-cell secretion determines glucagon release from neighbouring alpha-cells. Nature Cell Biology. 2003, 5: 330-335. 10.1038/ncb951.
Article
CAS
PubMed
Google Scholar
Ashcroft F, Rorsman P: Type 2 diabetes mellitus: not quite exciting enough?. Human Molecular Genetics. 2004, 13: R21-31. 10.1093/hmg/ddh066.
Article
CAS
PubMed
Google Scholar
Priel T, Hershfinkel M: Zinc influx and physiological consequences in the β-insulinoma cell line, Min6. Biochem Biophys Res Commun. 2006, 346: 205-212. 10.1016/j.bbrc.2006.05.104.
Article
CAS
PubMed
Google Scholar
Rabinovitch A, Suarez-Pinzon WL, Strynadka K, Lakey JR, Rajotte RV: Human pancreatic islet β-cell destruction by cytokines involves oxygen free radicals and aldehyde production. J Clin Endocrinol Metab. 1996, 81: 3197-202. 10.1210/jc.81.9.3197.
CAS
PubMed
Google Scholar
Kinlaw WB, Levine AS, Morley JE, Silvis SE, McClain CJ: Abnormal zinc metabolism in type II diabetes mellitus. American Journal of Medicine. 1983, 75: 273-277. 10.1016/0002-9343(83)91205-6.
Article
CAS
PubMed
Google Scholar
Pai LH, Prasad AS: Abnormal zinc metabolism in type II diabetes mellitus. Nutr Res. 1988, 8: 899-897. 10.1016/S0271-5317(88)80128-3.
Article
Google Scholar
Søndergaard LG, Stoltenberg M, Flyvbjerg A, Brock B, Schmitz O, Danscher G, Rungby J: Zinc ions in β-cells of obese, insulin-resistant, and type 2 diabetic rats traced by autometallography. APMIS. 2003, 111: 1147-1154. 10.1111/j.1600-0463.2003.apm1111211.x.
Article
PubMed
Google Scholar
Kambe T, Yamaguchi-Iwai Y, Sasaki R, Nagao M: Overview of mammalian zinc transporters. Cell Mol Life Sci. 2004, 61: 49-68. 10.1007/s00018-003-3148-y.
Article
CAS
PubMed
Google Scholar
Cousins RJ, Liuzzi JP, Lichten LA: Mammalian zinc transport, trafficking, and signals. Journal of Biological Chemistry. 2006, 281: 24085-24089. 10.1074/jbc.R600011200.
Article
CAS
PubMed
Google Scholar
Magnusson N, Bjerre Knudsen LB, Wogensen L, Brock , Schmitz O, Egefjord L, Jeppesen JB, Rungby J: The long-acting GLP-1 analogue liraglutide regulates zinc transporter mRNA in β cells. 0144 Diabetologia. 2007, 50: S65-
Google Scholar
Jeppesen JB, Larsen A, Jessen N: Glucose and zinc-depletion stimulate beta cell expression of ZnT3, a zinc transporter, whereas ZnT3 KO mice have decreased beta cell capacity. Diabetologia. 2007, 50: S207-
Google Scholar
Chimienti F, Devergnas S, Pattou F, Schuit F, Garcia-Cuenca R, Vandewalle B, Kerr-Conte J, Van Lommel L, Grunwald D, Favier A, Seve M: In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion. Journal of Cell Science. 2006, 119: 4199-4206. 10.1242/jcs.03164.
Article
CAS
PubMed
Google Scholar
Stoltenberg M, Bush AI, Bach G, Smidt K, Larsen A, Rungby J, Lund S, Doering P, Danscher G: Amyloid plaques arise from zinc-enriched cortical layers in APP/PS1 transgenic mice and are paradoxically enlarged with dietary zinc deficiency. Neuroscience. 2007, 5: 357-369. 10.1016/j.neuroscience.2007.09.025.
Article
Google Scholar
Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D, Boutin P, Vincent D, Belisle A, Hadjadj S, Balkau B, Heude B, Charpentier G, Hudson TJ, Montpetit A, Pshezhetsky AV, Prentki M, Posner BI, Balding DJ, Meyre D, Polychronakos C, Froguel P: A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature. 2007, 445: 881-885. 10.1038/nature05616.
Article
CAS
PubMed
Google Scholar
Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD, Doney AS, Wellcome Trust Case Control Consortium (WTCCC), McCarthy MI, Hattersley AT: Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science. 2007, 316: 1336-1341. 10.1126/science.1142364.
Article
CAS
PubMed
PubMed Central
Google Scholar
Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, Prokunina-Olsson L, Ding CJ, Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li XY, Conneely KN, Riebow NL, Sprau AG, Tong M, White PP, Hetrick KN, Barnhart MW, Bark CW, Goldstein JL, Watkins L, Xiang F, Saramies J, Buchanan TA, Watanabe RM, Valle TT, Kinnunen L, Abecasis GR, Pugh EW, Doheny KF, Bergman RN, Tuomilehto J, Collins FS, Boehnke M: A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science. 2007, 316: 1341-1345. 10.1126/science.1142382.
Article
CAS
PubMed
PubMed Central
Google Scholar
Steinthorsdottir V, Thorleifsson G, Reynisdottir I, Benediktsson R, Jonsdottir T, Walters GB, Styrkarsdottir U, Gretarsdottir S, Emilsson V, Ghosh S, Baker A, Snorradottir S, Bjarnason H, Ng MC, Hansen T, Bagger Y, Wilensky RL, Reilly MP, Adeyemo A, Chen Y, Zhou J, Gudnason V, Chen G, Huang H, Lashley K, Doumatey A, So WY, Ma RC, Andersen G, Borch-Johnsen K, Jorgensen T, van Vliet-Ostaptchouk JV, Hofker MH, Wijmenga C, Christiansen C, Rader DJ, Rotimi C, Gurney M, Chan JC, Pedersen O, Sigurdsson G, Gulcher JR, Thorsteinsdottir U, Kong A, Stefansson K: A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nature Genetics. 2007, 39: 770-775. 10.1038/ng2043.
Article
CAS
PubMed
Google Scholar
Wenzlau JM, Juhl K, Liping Y, Moua O, Sarkar SA, Gottlieb P, Rewers M, Eisenbarth GS, Jensen J, Davidson HW, Hutton JC: The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. PNAS. 2007, 104: 17040-17045. 10.1073/pnas.0705894104.
Article
CAS
PubMed
PubMed Central
Google Scholar
Brorsson C, Bergholdt R, Sjögren M, Eising S, Sørensen KM, Hougaard DM, Orho-Melander M, Groop L, Pociot F: A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population. Mol Genet Metab. 2008, 94 (3): 386-8. 10.1016/j.ymgme.2008.02.011.
Article
CAS
PubMed
Google Scholar
Qu HQ, Grant SF, Bradfield JP, Kim C, Frackelton E, Hakonarson H, Polychronakos C: Association analysis of type 2 diabetes Loci in type 1 diabetes. Diabetes. 2008, 57 (7): 1983-6. 10.2337/db08-0270.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sparre T, Larsen MR, Heding PE, Karlsen AE, Jensen ON, Pociot F: Unraveling the pathogenesis of type 1 diabetes with proteomics: present and future directions. Molecular and Cellular Proteomics. 2005, 4: 441-457. 10.1074/mcp.R500002-MCP200.
Article
CAS
PubMed
Google Scholar
Nielsen K, Kruhøffer M, Ørntoft T, Sparre T, Wang H, Wollheim C, Jørgensen MC, Nerup J, Karlsen AE: Gene expression profiles during β cell maturation and after IL-1β exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1β sensitivity. Diabetologia. 2004, 48: 2185-2199. 10.1007/s00125-004-1578-1.
Article
Google Scholar
Kutlu B, Cardozo AK, Darville MI, Kruhøffer M, Magnusson N, Ørntoft T, Eizirik DL: Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells. Diabetes. 2003, 52: 2701-2719. 10.2337/diabetes.52.11.2701.
Article
CAS
PubMed
Google Scholar
Delaney CA, Pavlovic D, Hoorens A, Pipeleers DG, Eizirik DL: Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells. Endocrinology. 1997, 138: 2610-2614. 10.1210/en.138.6.2610.
CAS
PubMed
Google Scholar
Sandler S, Bendtzen K, Borg LA, Eizirik DL, Strandell E, Welsh N: Studies on the mechanisms causing inhibition of insulin secretion in rat pancreatic islets exposed to human interleukin-1 β indicate a perturbation in the mitochondrial function. Endocrinology. 1989, 124: 1492-1501.
Article
CAS
PubMed
Google Scholar
Welsh N, Margulis B, Borg LA, Wiklund HJ, Saldeen J, Flodström M, Mello MA, Andersson A, Pipeleers DG, Hellerström C: Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: implications for the pathogenesis of insulin-dependent diabetes mellitus. Molecular Medicine. 1995, 1: 806-820.
CAS
PubMed
PubMed Central
Google Scholar
Ohara-Imaizumi M, Cardozo AK, Kikuta T, Eizirik DL, Nagamatsu S: The cytokine interleukin-1beta reduces the docking and fusion of insulin granules in pancreatic beta-cells, preferentially decreasing the first phase of exocytosis. Journal of Biological Chemistry. 2004, 279: 41271-41274. 10.1074/jbc.C400360200.
Article
CAS
PubMed
Google Scholar
Cavallo MG, Monetini L, Valente L, Barone F, Beales P, Russo M, Pozzilli P: Glutathione protects a human insulinoma cell line from tumor necrosis factor-alpha-mediated cytotoxicity. International Journal of Clinical and Laboratory Research. 1997, 27: 44-47. 10.1007/BF02827241.
Article
CAS
PubMed
Google Scholar
Lortz S, Tiedge M, Nachtwey T, Karlsen AE, Nerup J, Lenzen S: Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes. Diabetes. 2000, 49: 1123-1130. 10.2337/diabetes.49.7.1123.
Article
CAS
PubMed
Google Scholar
Chen H, Carlson EC, Pellet L, Moritz JT, Epstein PN: Overexpression of metallothionein in pancreatic β-cells reduces streptozotocin-induced DNA damage and diabetes. Diabetes. 2001, 50: 2040-2046. 10.2337/diabetes.50.9.2040.
Article
CAS
PubMed
Google Scholar
Casteele Van de M, Kefas BA, Ling Z, Heimberg H, Pipeleers DG: Specific expression of Bax-omega in pancreatic β-cells is down regulated by cytokines before the onset of apoptosis. Endocrinology. 2002, 143: 320-326. 10.1210/en.143.1.320.
PubMed
Google Scholar
Oltvai ZN, Milliman CL, Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 1993, 27: 609-619. 10.1016/0092-8674(93)90509-O.
Article
Google Scholar
Andersen HU, Mauricio D, Karlsen AE, Mandrup-Poulsen T, Nielsen JH, Nerup J: Interleukin-1 beta-induced nitric oxide production from isolated rat islets is modulated by D-glucose and 3-isobutyl-1-methyl xanthine. Eur J Endocrinol. 1996, 134 (2): 251-9. 10.1530/eje.0.1340251.
Article
CAS
PubMed
Google Scholar
Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T))Method. Methods. 2001, 25 (4): 402-8. 10.1006/meth.2001.1262.
Article
CAS
PubMed
Google Scholar
Zalewski PD, Millard SH, Forbes IJ, Kapaniris O, Slavotinek A, Betts WH, Ward AD, Lincoln SF, Mahadevan I: Video image analysis of labile zinc in viable pancreatic islet cells using a specific fluorescent probe for zinc. J Histochem Cytochem. 1994, 42: 877-884.
Article
CAS
PubMed
Google Scholar
Garg VK, Gupta R, Goyal RK: Hypozincemia in diabetes mellitus. Journal of Association of Physicians of India. 1994, 42: 720-721.
CAS
PubMed
Google Scholar
Roussel AM, Kerkeni A, Zouari N, Mahjoub S, Matheau JM, Anderson RA: Antioxidant effects of zinc supplementation in Tunisians with type 2 diabetes mellitus. Journal of the American College of Nutrition. 2003, 22: 316-321.
Article
CAS
PubMed
Google Scholar
Ho E, Quan N, Tsai YH, Lai W, Bray TM: Dietary zinc supplementation inhibits NFkappaB activation and protects against chemically induced diabetes in CD1 mice. Exp Biol Med (Maywood). 2001, 226: 103-111.
CAS
Google Scholar
Getz G, Levine E, Domany E: Coupled two-way clustering analysis of gene microarray data. Proc Natl Acad Sci U S A. 2000, 97: 12079-84. 10.1073/pnas.210134797.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chandra J, Yang SN, Köhler M, Zaitsev S, Juntti-Berggren L, Berggren PO, Zhivotovsky B, Orrenius S: Effects of serum from patients with type 1 diabetes on primary cerebellar granule cells. Diabetes. 2001, 50: 77-81. 10.2337/diabetes.50.2007.S77.
Article
Google Scholar
Chimieniti F, Seve M, Richard S, Mathieu J, Favier A: Role of cellular zinc in programmed cell death: temporal relationship between zinc depletion, activation of caspases, and cleavage of Sp family transcription factors. Biochemical Pharmacology. 2001, 62: 51-62. 10.1016/S0006-2952(01)00624-4.
Article
Google Scholar
Baynes JW: Role of oxidative stress in development of complications in diabetes. Diabetes. 1991, 40: 405-412. 10.2337/diabetes.40.4.405.
Article
CAS
PubMed
Google Scholar
Priel T, Hershfinkel M: Zinc influx and physiological consequences in the beta-insulinoma cell line, Min6. Biochem Biophys Res Commun. 2006, 346: 205-12. 10.1016/j.bbrc.2006.05.104.
Article
CAS
PubMed
Google Scholar
Palmer JP, Helqvist S, Spinas GA, Mølvig J, Mandrup-Poulsen T, Andersen HU, Nerup J: Interaction of beta-cell activity and IL-1 concentration and exposure time in isolated rat islets of Langerhans. Diabetes. 1989, 38 (10): 1211-6. 10.2337/diabetes.38.10.1211.
Article
CAS
PubMed
Google Scholar
Eizirik DL, Mandrup-Poulsen T: A choice of death – the signal-transduction of immune-mediated β-cell apoptosis. Diabetologia. 2001, 44: 2115-2133. 10.1007/s001250100021.
Article
CAS
PubMed
Google Scholar
Mandrup-Poulsen T: Apoptotic signal transduction pathways in diabetes. Biochem Pharmacol. 2003, 66 (8): 1433-40. 10.1016/S0006-2952(03)00494-5.
Article
CAS
PubMed
Google Scholar
Ortis F, Pirot P, Naamane N, Kreins AY, Rasschaert J, Moore F, Théâtre E, Verhaeghe C, Magnusson NE, Chariot A, Orntoft TF, Eizirik DL: Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells. Diabetologia. 2008, 51 (7): 1213-25. 10.1007/s00125-008-0999-7.
Article
CAS
PubMed
Google Scholar