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Table 2 Regulation of ZnT/Zip expression in INS-1 cells following cytokine exposure.

From: Zinc transporter gene expression is regulated by pro-inflammatory cytokines: a potential role for zinc transporters in beta-cell apoptosis?

  IL-1β/6 h IL-1β/24 h TNF-α/6 h TNF-α/24 h IFN-γ/6 h IFN-γ/24 h Mix./6 h Mix./24 h SEM
ZnT3 0.00 -0.58** -0.14 0.00 -0.14 -0.93** -0.14 -1.85** +/- 0.20
ZnT4 -0.38 0.00 -0.14 0.49* -0.49* -0.38* -0.49* 0.26 +/- 0.19
ZnT5 -0.14 0.00 0.00 0.26 -0.38 -0.38 -0.38 -0.26 +/- 0.23
ZnT6 -0.26** -0.26** -0.14 0.00 -0.26** -0.26* -0.14* -0.14 +/- 0.09
ZnT8 -0.38* 0.26 -0.14 0.26 -0.49** -0.38** -0.49** -1.81** +/- 0.16
Zip5 0.00 -0.14 -0.14 0.38 0.14 -0.77* -0.26 -0.38 +/- 0.36
Zip6 -0.00 -0.85** 0.00 0.00 -0.26 0.38* -0.14 -1.00** +/- 0.15
  1. Log2-fold changes are indicated (n = 6). (* p < 0.05, ** p < 0.01). Mix. is IL-1β+TNF-α+IFN-γ IL-1β. The last column indicates standard errors +/- SEM for log2 fold changes.