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Table 2 Regulation of ZnT/Zip expression in INS-1 cells following cytokine exposure.

From: Zinc transporter gene expression is regulated by pro-inflammatory cytokines: a potential role for zinc transporters in beta-cell apoptosis?

 

IL-1β/6 h

IL-1β/24 h

TNF-α/6 h

TNF-α/24 h

IFN-γ/6 h

IFN-γ/24 h

Mix./6 h

Mix./24 h

SEM

ZnT3

0.00

-0.58**

-0.14

0.00

-0.14

-0.93**

-0.14

-1.85**

+/- 0.20

ZnT4

-0.38

0.00

-0.14

0.49*

-0.49*

-0.38*

-0.49*

0.26

+/- 0.19

ZnT5

-0.14

0.00

0.00

0.26

-0.38

-0.38

-0.38

-0.26

+/- 0.23

ZnT6

-0.26**

-0.26**

-0.14

0.00

-0.26**

-0.26*

-0.14*

-0.14

+/- 0.09

ZnT8

-0.38*

0.26

-0.14

0.26

-0.49**

-0.38**

-0.49**

-1.81**

+/- 0.16

Zip5

0.00

-0.14

-0.14

0.38

0.14

-0.77*

-0.26

-0.38

+/- 0.36

Zip6

-0.00

-0.85**

0.00

0.00

-0.26

0.38*

-0.14

-1.00**

+/- 0.15

  1. Log2-fold changes are indicated (n = 6). (* p < 0.05, ** p < 0.01). Mix. is IL-1β+TNF-α+IFN-γ IL-1β. The last column indicates standard errors +/- SEM for log2 fold changes.