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  1. Activation of peroxisome proliferator-activated receptor (PPAR)gamma is associated with bone loss and increased fracture risk, while PPARalpha activation seems to have positive skeletal effects. To further exp...

    Authors: Astrid K Stunes, Irene Westbroek, Björn I Gustafsson, Reidar Fossmark, Jan H Waarsing, Erik F Eriksen, Christiane Petzold, Janne E Reseland and Unni Syversen
    Citation: BMC Endocrine Disorders 2011 11:11
  2. Interferon-α in combination with ribavirin is the current gold standard for treatment of chronic hepatitis C. It is unknown if the development of autoimmune thyroid disease (TD) during treatment confers an imp...

    Authors: Huy A Tran, Tracey L Jones, Robert Gibson and Glenn EM Reeves
    Citation: BMC Endocrine Disorders 2011 11:10
  3. The once-weekly (QW) formulation of the glucagon-like peptide-1 receptor agonist exenatide has been demonstrated to improve A1C, fasting plasma glucose (FPG), body weight, serum lipid profiles, and blood press...

    Authors: Kristin Taylor, Kate Gurney, Jenny Han, Richard Pencek, Brandon Walsh and Michael Trautmann
    Citation: BMC Endocrine Disorders 2011 11:9
  4. There is limited literature on hypernatreamia in the setting of hyperglycaemic crisis. This is despite the fact that the presence of hypernatreamia may impact on the classification of hyperglycaemic crisis and...

    Authors: Chukwuma O Ekpebegh, Benjamin Longo-Mbenza, Augustin Nge-Okwe, Anthonia O Ogbera and Nomawethu T Tonjeni
    Citation: BMC Endocrine Disorders 2011 11:8
  5. Adipose tissue abundance relies partly on the factors that regulate adipogenesis, i.e. proliferation and differentiation of adipocytes. While components of the transcriptional program that initiates adipogenes...

    Authors: Pernille Keller, Valentina Gburcik, Natasa Petrovic, Iain J Gallagher, Jan Nedergaard, Barbara Cannon and James A Timmons
    Citation: BMC Endocrine Disorders 2011 11:7
  6. Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders caused by defects in the steroid 21 hydroxylase gene (CYP21A2). We studied the spectrum of mutations in CYP21A2 gene in a multi-...

    Authors: Aysha H Khan, Muniba Aban, Jamal Raza, Naeem ul Haq, Abdul Jabbar and Tariq Moatter
    Citation: BMC Endocrine Disorders 2011 11:5
  7. Accurately monitoring adherence to treatment with recombinant human growth hormone (r-hGH) enables appropriate intervention in cases of poor adherence. The electronic r-hGH auto-injector, easypod™, automatical...

    Authors: Mauro Bozzola, Michel Colle, Maria Halldin-Stenlid, Sylvain Larroque and Monia Zignani
    Citation: BMC Endocrine Disorders 2011 11:4
  8. The objective of this study was to characterize insulin use and examine factors associated with persistence to mealtime insulin among patients with type 2 diabetes (T2D) on stable basal insulin therapy initiat...

    Authors: Machaon M Bonafede, Anupama Kalsekar, Manjiri Pawaskar, Kimberly M Ruiz, Amelito M Torres, Karen R Kelly and Suellen M Curkendall
    Citation: BMC Endocrine Disorders 2011 11:3
  9. Haematopoietic stem cells undergo mobilization from bone marrow to blood in response to physiological stimuli such as ischemia and tissue injury. The aim of study was to determine the kinetics of circulating CD34

    Authors: Abel A Nathan, Viswanathan Mohan, Subash S Babu, Soumi Bairagi and Madhulika Dixit
    Citation: BMC Endocrine Disorders 2011 11:2
  10. Research has investigated whether communication technologies (e.g. mobile telephony, forums, email) can be used to transfer digital information between healthcare professionals and young people who live with d...

    Authors: Paul Sutcliffe, Steven Martin, Jackie Sturt, John Powell, Frances Griffiths, Ann Adams and Jeremy Dale
    Citation: BMC Endocrine Disorders 2011 11:1
  11. Insulin responses and insulin levels seem to decline with age. However, the question of beta cell impairment attributable to ageing has been sparsely addressed in population-based studies. Non-fasting insulin ...

    Authors: Bente Bryhni, Egil Arnesen and Trond G Jenssen
    Citation: BMC Endocrine Disorders 2010 10:21
  12. Glucagon-like peptide (GLP-1) analogues are a new class of drugs used in the treatment of type 2 diabetes. They are given by injection, and regulate glucose levels by stimulating glucose-dependent insulin secr...

    Authors: Deepson S Shyangdan, Pamela L Royle, Christine Clar, Pawana Sharma and Norman R Waugh
    Citation: BMC Endocrine Disorders 2010 10:20
  13. The most common cause of hypopituitarism is pituitary adenoma. However, in the case of suprasellar masses different etiologies are possible. We report an unusual case of primary suprasellar lymphoma presented ...

    Authors: Zouhour Fadoukhair, Mounia Amzerin, Nabil Ismaili, Rhizlane Belbaraka, Rachida Latib, Yassir Sbitti, Hind M'rabti, Saber Boutayeb, Mohammed Ichou and Hassan Errihani
    Citation: BMC Endocrine Disorders 2010 10:19
  14. To investigate disease progression the first 12 months after diagnosis in children with type 1 diabetes negative (AAB negative) for pancreatic autoantibodies [islet cell autoantibodies(ICA), glutamic acid deca...

    Authors: Sven Pörksen, Lene Bjerke Laborie, Lotte Nielsen, Marie Louise Max Andersen, Tone Sandal, Heidi de Wet, Erik Schwarcz, Jan Åman, Peter Swift, Mirjana Kocova, Eugen J Schönle, Carine de Beaufort, Philip Hougaard, Frances Ashcroft, Anders Molven, Mikael Knip…
    Citation: BMC Endocrine Disorders 2010 10:16
  15. Diabetes mellitus places a considerable burden on patients in terms of morbidity and mortality and on society in terms of costs. Costs related to diabetes are expected to increase due to increasing prevalence ...

    Authors: Oddvar Solli, Trond Jenssen and Ivar S Kristiansen
    Citation: BMC Endocrine Disorders 2010 10:15
  16. At diabetes diagnosis major decisions about life-style changes and treatments are made based on characteristics measured shortly after diagnosis. The predictive value for mortality of these early characteristi...

    Authors: Niels de Fine Olivarius, Volkert Siersma, Anni BS Nielsen, Lars J Hansen, Lotte Rosenvinge and Carl Erik Mogensen
    Citation: BMC Endocrine Disorders 2010 10:14
  17. Cause-specific mortality is a commonly used endpoint of clinical trials or prospective studies. However, it is sometimes difficult for physician to determine the underlying-cause-of-death (UCD), especially for...

    Authors: Tsung-Hsueh Lu, Ching-Fai Kwok and Low-Tone Ho
    Citation: BMC Endocrine Disorders 2010 10:13
  18. Hypovitaminosis D is a common condition among elderly individuals in temperate-climate countries, with a clear seasonal variation on 25 hydroxyvitamin D levels, increasing after summer and decreasing after win...

    Authors: Sergio S Maeda, Ilda S Kunii, Lilian F Hayashi and Marise Lazaretti-Castro
    Citation: BMC Endocrine Disorders 2010 10:12
  19. The metabolic syndrome (MetS) concept is widely used in public health and clinical settings without an agreed pathophysiology. We have re-examined the MetS in terms of body fuels, so as to provide a coherent c...

    Authors: Mark L Wahlqvist, Hsing-Yi Chang, Chu-Chih Chen, Chih-Cheng Hsu, Wan-Chi Chang, Wuan-Szu Wang and Chao A Hsiung
    Citation: BMC Endocrine Disorders 2010 10:11
  20. Pituitary adenomas are associated with a variety of clinical manifestations resulting from excessive hormone secretion and tumor mass effects, and require a multidisciplinary management approach. This article ...

    Authors: Beverly MK Biller, Annamaria Colao, Stephan Petersenn, Vivien S Bonert and Marco Boscaro
    Citation: BMC Endocrine Disorders 2010 10:10
  21. Transcription factor 7-like 2 (TCF7L2) has emerged as a consistently replicated susceptibility gene for type 2 diabetes, however, whether the TCF7L2 gene also has similar effects on the retinal microvasculature i...

    Authors: Yu Yan, Ronald Klein, Gerardo Heiss, Cynthia J Girman, Ethan M Lange, Barbara E Klein, Kathryn M Rose, Eric Boerwinkle, James S Pankow, Frederick L Brancati, Christie M Ballantyne, Anna Köttgen and Kari E North
    Citation: BMC Endocrine Disorders 2010 10:9
  22. In recent years, there has been an increasing attention to thyroid function in paediatric obese patients. In the present study we aimed 1) to determine the prevalence of abnormally elevated thyroid-stimulating...

    Authors: Anna Grandone, Nicola Santoro, Filomena Coppola, Paolo Calabrò, Laura Perrone and Emanuele Miraglia del Giudice
    Citation: BMC Endocrine Disorders 2010 10:8
  23. In a previous pooled analysis of 12 double-blind clinical studies that included data on 6,139 patients with type 2 diabetes, treatment with sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, was shown to...

    Authors: Debora Williams-Herman, Samuel S Engel, Elizabeth Round, Jeremy Johnson, Gregory T Golm, Hua Guo, Bret J Musser, Michael J Davies, Keith D Kaufman and Barry J Goldstein
    Citation: BMC Endocrine Disorders 2010 10:7
  24. Low skeletal muscle mass is associated with insulin resistance and metabolic syndrome. Serum creatinine may serve as a surrogate marker of muscle mass, and a possible relationship between low serum creatinine ...

    Authors: Jøran Hjelmesæth, Jo Røislien, Njord Nordstrand, Dag Hofsø, Helle Hager and Anders Hartmann
    Citation: BMC Endocrine Disorders 2010 10:6
  25. Endothelial progenitor cells (EPCs) play an important role in vascular repair and a decrease in the number of EPCs is observed in type 2 diabetes. However, there is no report on the change of EPCs after glycem...

    Authors: Worachat Churdchomjan, Pakpoom Kheolamai, Sirikul Manochantr, Pirath Tapanadechopone, Chairat Tantrawatpan, Yaowalak U-pratya and Surapol Issaragrisil
    Citation: BMC Endocrine Disorders 2010 10:5
  26. Type 2 diabetes mellitus (T2DM) and several types of neurodegeneration, including Alzheimer's, are linked to insulin-resistance, and chronic high dietary fat intake causes T2DM with mild neurodegeneration. Int...

    Authors: Ming Tong, Lisa Longato and Suzanne M de la Monte
    Citation: BMC Endocrine Disorders 2010 10:4
  27. Obesity, type 2 diabetes mellitus (T2D) and unhealthy blood lipid profile are strongly associated with the risk of developing cardiovascular disease (CVD). We examined whether blood lipid changes with short te...

    Authors: Peter Weeke, Charlotte Andersson, Emil L Fosbøl, Bente Brendorp, Lars Køber, Arya M Sharma, Nick Finer, Philip T James, Ian D Caterson, Richard A Rode and Christian Torp-Pedersen
    Citation: BMC Endocrine Disorders 2010 10:3
  28. Iodine deficiency is a global problem representing the most common preventable cause of mental retardation. Recently, the impact of subtle deficiencies in iodine intake on children and pregnant women has been ...

    Authors: Marcus M Cranston, Margaret AK Ryan, Tyler C Smith, Carter J Sevick and Stephanie K Brodine
    Citation: BMC Endocrine Disorders 2010 10:2
  29. Mice lacking Receptor-interacting protein 140 (RIP140) have reduced body fat which at least partly is mediated through increased lipid and glucose metabolism in adipose tissue. In humans, RIP140 is lower expresse...

    Authors: Niklas Mejhert, Jurga Laurencikiene, Amanda T Pettersson, Maria Kaaman, Britta M Stenson, Mikael Rydén and Ingrid Dahlman
    Citation: BMC Endocrine Disorders 2010 10:1
  30. A significant body of literature indicates that melatonin, a hormone primarily produced nocturnally by the pineal gland, is an important scavenger of hydroxyl radicals and other reactive oxygen species. Melato...

    Authors: Zoreh Davanipour, Henrik E Poulsen, Allan Weimann and Eugene Sobel
    Citation: BMC Endocrine Disorders 2009 9:22
  31. Numerous studies have reported that age-induced increased parathyroid hormone plasma levels are associated with cognitive decline and dementia. Little is known about the correlation that may exist between neur...

    Authors: Eric R Braverman, Thomas JH Chen, Amanda LC Chen, Vanessa Arcuri, Mallory M Kerner, Anish Bajaj, Javier Carbajal, Dasha Braverman, B William Downs and Kenneth Blum
    Citation: BMC Endocrine Disorders 2009 9:21
  32. Acromegaly, an orphan disease usually caused by a benign pituitary tumour, is characterised by hyper-secretion of growth hormone (GH) and insulin-like growth factor I (IGF-1). It is associated with reduced lif...

    Authors: David J Moore, Yaser Adi, Martin J Connock and Sue Bayliss
    Citation: BMC Endocrine Disorders 2009 9:20
  33. Recent data have shown that type 2 diabetes patients in the UK delay initiating insulin on average for over 11 years after first being prescribed an oral medication. Using a published computer simulation model...

    Authors: Gordon Goodall, Eric M Sarpong, Clarice Hayes and William J Valentine
    Citation: BMC Endocrine Disorders 2009 9:19
  34. While the adverse impact of a history of a foot ulcer on physical health among persons with diabetes is well known, little is known about the association between foot ulcer, perceived health and psychological ...

    Authors: Marjolein M Iversen, Kristian Midthjell, Grethe S Tell, Torbjørn Moum, Truls Østbye, Monica W Nortvedt, Sverre Uhlving and Berit R Hanestad
    Citation: BMC Endocrine Disorders 2009 9:18
  35. Impaired glucose tolerance (IGT) is a prediabetic state. If IGT can be prevented from progressing to overt diabetes, hyperglycemia-related complications can be avoided. The purpose of the present study was to ...

    Authors: Ralph A DeFronzo, MaryAnn Banerji, George A Bray, Thomas A Buchanan, Stephen Clement, Robert R Henry, Abbas E Kitabchi, Sunder Mudaliar, Nicolas Musi, Robert Ratner, Peter D Reaven, Dawn Schwenke, Frankie B Stentz and Devjit Tripathy
    Citation: BMC Endocrine Disorders 2009 9:17
  36. Most studies on cortisol have focused on smaller, selected samples. We therefore aimed to sex-specifically study the diurnal cortisol pattern and explore its association with abdominal obesity in a large unsel...

    Authors: Charlotte A Larsson, Bo Gullberg, Lennart Råstam and Ulf Lindblad
    Citation: BMC Endocrine Disorders 2009 9:16
  37. While there are compelling observational data confirming that individuals who exercise are healthier, the efficacy of aerobic exercise interventions to reduce metabolic risk and improve insulin sensitivity in ...

    Authors: Francis M Finucane, Jessica Horton, Lisa R Purslow, David B Savage, Soren Brage, Hervé Besson, Kenneth Horton, Ema De Lucia Rolfe, Alison Sleigh, Stephen J Sharp, Helen J Martin, Avan Aihie Sayer, Cyrus Cooper, Ulf Ekelund, Simon J Griffin and Nicholas J Wareham
    Citation: BMC Endocrine Disorders 2009 9:15
  38. The rising prevalence of type 2 diabetes underlines the importance of secondary strategies for the prevention of target organ damage. While access to diabetes education centers and diabetes intensification man...

    Authors: Sheldon W Tobe, Joan Wentworth, Laurie Ironstand, Susan Hartman, Jackie Hoppe, Judi Whiting, Janice Kennedy, Colin McAllister, Alex Kiss, Nancy Perkins, Lloyd Vincent, George Pylypchuk and Richard Z Lewanczuk
    Citation: BMC Endocrine Disorders 2009 9:13
  39. A lot of studies have showed an excess maternal transmission of type 2 diabetes (T2D). The aim, therefore, of the present study was to estimate the prevalence of familial history of T2D in Greek patients, and ...

    Authors: Athanasia Papazafiropoulou, Alexios Sotiropoulos, Eystathios Skliros, Marina Kardara, Anthi Kokolaki, Ourania Apostolou and Stavros Pappas
    Citation: BMC Endocrine Disorders 2009 9:12
  40. Primary aldosteronism (PA) affects approximately 5 to 10% of all patients with arterial hypertension and is associated with an excess rate of cardiovascular complications that can be significantly reduced by a...

    Authors: Stefan Pilz, Andreas Tomaschitz, Vinzenz Stepan, Barbara Obermayer-Pietsch, Astrid Fahrleitner-Pammer, Natascha Schweighofer, Horst R Portugaller, Harald Sourij, Harald Dobnig, Andreas Meinitzer and Thomas R Pieber
    Citation: BMC Endocrine Disorders 2009 9:11
  41. All the peroxisome proliferator activated receptors (PPARs) are found to be expressed in bone cells. The PPARγ agonist rosiglitazone has been shown to decrease bone mass in mice and thiazolidinediones (TZDs) h...

    Authors: Unni Syversen, Astrid K Stunes, Björn I Gustafsson, Karl J Obrant, Lars Nordsletten, Rolf Berge, Liv Thommesen and Janne E Reseland
    Citation: BMC Endocrine Disorders 2009 9:10
  42. Hyperglycaemic emergencies are common acute complications of diabetes mellitus (DM) but unfortunately, there is a dearth of published data on this entity from Nigeria. This study attempts to describe the clini...

    Authors: Anthonia O Ogbera, Jacob Awobusuyi, Chioma Unachukwu and Olufemi Fasanmade
    Citation: BMC Endocrine Disorders 2009 9:9
  43. Rosiglitazone not only improves insulin-sensitivity, but also exerts anti-inflammatory effects. We have now examined in type 2 diabetic patients if these effects are reflected by changes in mRNA expression in ...

    Authors: Marjolijn CE Bragt, Jogchum Plat, Marco Mensink, Patrick Schrauwen and Ronald P Mensink
    Citation: BMC Endocrine Disorders 2009 9:8
  44. β-cells are extremely rich in zinc and zinc homeostasis is regulated by zinc transporter proteins. β-cells are sensitive to cytokines, interleukin-1β (IL-1β) has been associated with β-cell dysfunction and -de...

    Authors: Lærke Egefjord, Jens Ledet Jensen, Claus Heiner Bang-Berthelsen, Andreas Brønden Petersen, Kamille Smidt, Ole Schmitz, Allan Ertman Karlsen, Flemming Pociot, Fabrice Chimienti, Jørgen Rungby and Nils E Magnusson
    Citation: BMC Endocrine Disorders 2009 9:7
  45. The management of diabetes self-care is largely the responsibility of the patient. With more emphasis on the prevention of complications, adherence to diabetes self-care regimens can be difficult. Diabetes sel...

    Authors: Margaret M Collins, Colin P Bradley, Tony O'Sullivan and Ivan J Perry
    Citation: BMC Endocrine Disorders 2009 9:6
  46. The objective was to examine how the indigenous naming, indigenous self-diagnosis and management of diabetes evolved with awareness in order to develop a socially oriented theoretical model for its care.

    Authors: Paschal K Awah, Nigel C Unwin and Peter R Phillimore
    Citation: BMC Endocrine Disorders 2009 9:5

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