Articles

Screening for celiac disease in poorly controlled type 2 diabetes mellitus: worth it or not?

Recent studies have demonstrated that immune factors might have a role in the pathophysiology of insulin resistance and type 2 diabetes mellitus (T2DM). Inappropriate glycemic control in patients with T2DM is ...

Authors: Muhammed Kizilgul, Ozgur Ozcelik, Selvihan Beysel, Hakan Akinci, Seyfullah Kan, Bekir Ucan, Mahmut Apaydin and Erman Cakal

Hypertension outcomes of adrenalectomy in patients with primary aldosteronism: a systematic review and meta-analysis

The hypertension cure rate of unilateral adrenalectomy in primary aldosteronism (PA) patients varies widely in existing studies.

Authors: Yu Zhou, Meilian Zhang, Sujie Ke and Libin Liu

The relationship between bile acid concentration, glucagon-like-peptide 1, fibroblast growth factor 15 and bile acid receptors in rats during progression of glucose intolerance

Recent studies show that bile acids are involved in glucose and energy homeostasis through activation of G protein coupled membrane receptor (TGR5) and farnesoid X receptor (FXR). A few researches have explore...

Authors: Xinfeng Yan, Peicheng Li, Zhaosheng Tang and Bo Feng

Prepubertal onset of slipped capital femoral epiphysis associated with hypothyroidism: a case report and literature review

Slipped capital femoral epiphysis (SCFE) is a common hip disorder characterized by displacement of the capital femoral epiphysis from the metaphysic through the femoral epiphyseal plate. SCFE usually occurs du...

Authors: Saori Kadowaki, Tomohiro Hori, Hideki Matsumoto, Kaori Kanda, Michio Ozeki, Yu Shirakami, Norio Kawamoto, Hidenori Ohnishi and Toshiyuki Fukao

Clinical characteristics of adrenal crisis in adult population with and without predisposing chronic adrenal insufficiency: a retrospective cohort study

Adrenal crisis (AC) occurs in various clinical conditions but previous epidemiological studies in AC are limited to chronic adrenal insufficiency (AI) and sepsis. The aim of this study was to investigate chara...

Authors: Masahiro Iwasaku, Maki Shinzawa, Shiro Tanaka, Kimihiko Kimachi and Koji Kawakami

Primary hyperparathyroidism caused by enormous unilateral water-clear cell parathyroid hyperplasia

Parathyroid water-clear cell hyperplasia (WCCH) and water-clear cell adenoma (WCCA) are rare causes of primary hyperparathyroidism. The frequency of WCCH seems to be less than 1% of all primary hyperplasia.

Authors: Georgios Boutzios, Helen Sarlanis, Anna Kolindou, Antigoni Velidaki and Theodore Karatzas

Awareness and practices regarding eye diseases among patients with diabetes: a cross sectional analysis of the CoDiab-VD cohort

The increasing prevalence of diabetes is leading to a rise of eye diseases, augmenting the risk of sight-threatening complications. The aim of this study was to evaluate prevalence, awareness and practices reg...

Authors: Lazaros Konstantinidis, Tania Carron, Eva de Ancos, Léonie Chinet, Isabelle Hagon-Traub, Emilie Zuercher and Isabelle Peytremann-Bridevaux

Prolonged preoperative treatment of acromegaly with Somatostatin analogs may improve surgical outcome in patients with invasive pituitary macroadenoma (Knosp grades 1–3): a retrospective cohort study conducted at a single center

This study aimed to investigate preoperative somatostatin analogs (SSAs) treatment on the surgical outcome in patients with acromegaly.

Authors: Lian Duan, Huijuan Zhu, Bing Xing and Feng Gu

Multihormonal pituitary adenoma concomitant with Pit-1 and Tpit lineage cells causing acromegaly associated with subclinical Cushing’s disease: a case report

A functional pituitary adenoma can produce multiple anterior-pituitary hormones, such as growth hormone (GH) -producing adenomas (GHoma) with prolactin or thyrotropin stimulating hormone production in the same...

Authors: Tomoko Takiguchi, Hisashi Koide, Hidekazu Nagano, Akitoshi Nakayama, Masanori Fujimoto, Ai Tamura, Eri Komai, Akina Shiga, Takashi Kono, Seiichiro Higuchi, Ikki Sakuma, Naoko Hashimoto, Sawako Suzuki, Yui Miyabayashi, Norio Ishiwatari, Kentaro Horiguchi…

Insulin treatment corrects hepcidin but not YKL-40 levels in persons with type 2 diabetes mellitus matched by body mass index, waist-to-height ratio, C-reactive protein and Creatinine

It has been shown that hepcidin and YKL-40 levels change in persons with insulin resistance in different circumstances. However, variations of the levels of these parameters through the stages of prediabetes a...

Authors: Driton Vela, Jovica Leshoski, Zana Vela, Muharrem Jakupaj, Mitko Mladenov and Ramadan B. Sopi

Participation of adults with disorders/differences of sex development (DSD) in the clinical study dsd-LIFE: design, methodology, recruitment, data quality and study population

dsd-LIFE is a comprehensive cross-sectional clinical outcome study of individuals with disorders/differences of sex development (DSD). This study focuses on various rare genetic conditions characterized by imp...

Authors: Robert Röhle, Katharina Gehrmann, Maria Szarras-Czapnik, Hedi Claahsen-van der Grinten, Catherine Pienkowski, Claire Bouvattier, Peggy Cohen-Kettenis, Anna Nordenström, Ute Thyen and Birgit Köhler

Variations in diabetes remission rates after bariatric surgery in Spanish adults according to the use of different diagnostic criteria for diabetes

There are multiple criteria to define remission of type 2 diabetes (DM2) after bariatric surgery but there is not a specific one widely accepted. Our objectives were to compare diagnostic criteria for DM2 remi...

Authors: María R. Alhambra-Expósito, María J. Molina-Puerta, María I. Prior-Sánchez, Gregorio Manzano-García, Alfonso Calañas-Continente and María A. Gálvez-Moreno

The role of bariatric surgery to treat diabetes: current challenges and perspectives

Bariatric surgery is emerging as a powerful weapon against severe obesity and type 2 diabetes mellitus (T2DM). Given its role in metabolic regulation, the gastrointestinal tract constitutes a meaningful target...

Authors: Chrysi Koliaki, Stavros Liatis, Carel W. le Roux and Alexander Kokkinos

Long-term treatment outcomes of acromegaly patients presenting biochemically-uncontrolled at a tertiary pituitary center

Acromegaly is a rare, slowly progressive disorder resulting from excessive growth hormone (GH) production by a pituitary somatotroph tumor. The objective of this study was to examine acromegaly treatment outco...

Authors: John D. Carmichael, Michael S. Broder, Dasha Cherepanov, Eunice Chang, Adam Mamelak, Qayyim Said, Maureen P. Neary and Vivien Bonert

Renal injury is accelerated by global hypoxia-inducible factor 1 alpha deficiency in a mouse model of STZ-induced diabetes

Hypoxia inducible factor 1 (HIF-1) activates protective pathways to counteract hypoxia and prevent tissue damage in conjunction with renal injury. The aim of this study was to evaluate a role of HIF-1 in diabe...

Authors: Romana Bohuslavova, Radka Cerychova, Katerina Nepomucka and Gabriela Pavlinkova

Exploration of knowledge and understanding in patients with primary adrenal insufficiency: a mixed methods study

Primary adrenal insufficiency (PAI) is a rare and severe condition requiring lifelong steroid replacement. During acute illness or stressful events, it is important to appropriately adjust glucocorticoid dose;...

Authors: L. M Shepherd, A. A Tahrani, C Inman, W Arlt and D. M Carrick-Sen

A comparative effectiveness study of two culturally competent models of diabetes self-management programming for Latinos from low-income households

Diabetes risk is extremely high for Latinos from low-income households. Health guidelines recommend that individuals learn strategies to self-manage their diabetes, but getting people to adopt required lifesty...

Authors: Janet Page-Reeves, Lidia Regino, Cristina Murray-Krezan, Molly Bleecker, Erik Erhardt, Mark Burge, Elaine Bearer and Shiraz Mishra

Case report: rare skeletal manifestations in a child with primary hyperparathyroidism

Primary hyperparathyroidism (PHPT) is uncommon among children with an incidence of 1:300,000. This diagnosis is often missed in children in contrast to adults where it is detected at a pre symptomatic stage du...

Authors: Maulee Hiromi Arambewela, Kamani Danushka Liyanarachchi, Noel P. Somasundaram, Aruna S. Pallewatte and Gamini L. Punchihewa

Elevated C-reactive protein, interleukin 6, tumor necrosis factor alpha and glycemic load associated with type 2 diabetes mellitus in rural Thais: a cross-sectional study

The elevated levels of inflammatory markers, including C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α), and interleukin 6 (IL6) are supposed to be associated with type 2 diabetes mellitus (T2DM)....

Authors: Chanchira Phosat, Pornpimol Panprathip, Noppanath Chumpathat, Pattaneeya Prangthip, Narisara Chantratita, Ngamphol Soonthornworasiri, Somchai Puduang and Karunee Kwanbunjan

Erratum to: Metabolic syndrome and its predictors in an urban population in Kenya: a cross sectional study

Authors: Geoffrey Omuse, Daniel Maina, Mariza Hoffman, Jane Mwangi, Caroline Wambua, Elizabeth Kagotho, Angela Amayo, Peter Ojwang, Zulfiqarali Premji, Kiyoshi Ichihara and Rajiv Erasmus

Erratum to: Acute airway compromise due to parathyroid tumour apoplexy: an exceptionally rare and potentially life-threatening presentation

Authors: Aoife Garrahy, David Hogan, James Paul O’Neill and Amar Agha

Endocannabinoid receptor blockade reduces alanine aminotransferase in polycystic ovary syndrome independent of weight loss

Evidence suggests that endocannabinoid system activation through the cannabinoid receptor 1 (CB1) is associated with enhanced liver injury, and CB1 antagonism may be beneficial. The aim of this study was to de...

Authors: Alison J. Dawson, Eric S. Kilpatrick, Anne-Marie Coady, Abeer M. M. Elshewehy, Youssra Dakroury, Lina Ahmed, Stephen L. Atkin and Thozhukat Sathyapalan

Metabolic characteristics of individuals at a high risk of type 2 diabetes – a comparative cross-sectional study

Type 2 diabetes (T2D) is associated with substantial morbidity and mortality. Individuals with a family history of T2D are at an increased risk of developing the disease. The aim of this study was to assess me...

Authors: Josefin Henninger, Araz Rawshani, Ann Hammarstedt and Björn Eliasson

Clinicopathological features and prognosis of gastroenteropancreatic neuroendocrine neoplasms in a Chinese population: a large, retrospective single-centre study

Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are the most common type of neuroendocrine tumors, accounting for more than half of neuroendocrine neoplasms (NENs). We performed a retrospective stud...

Authors: Meng Zhang, Ping Zhao, Xiaodan Shi, Ahong Zhao, Lianfeng Zhang and Lin Zhou

Health-related quality of life in type-2 diabetes patients: a cross-sectional study in East China

Used the EuroQoL-5 dimension (EQ-5D) to evaluate the health status of 5310 residents who live in East China, and compared the health-related quality of life (HRQoL) with 311 patients with type 2 diabetes as we...

Authors: You Lu, Ningjian Wang, Yi Chen, Xiaomin Nie, Qin Li, Bing Han, Yingchao Chen, Fangzhen Xia, Zhen Cang, Meng Lu, Ying Meng and Yingli Lu

Metabolic syndrome and its predictors in an urban population in Kenya: A cross sectional study

The metabolic syndrome (MetS) is a clustering of interrelated risk factors which doubles the risk of cardio-vascular disease (CVD) in 5–10 years and increases the risk of type 2 diabetes 5 fold. The identifica...

Authors: Geoffrey Omuse, Daniel Maina, Mariza Hoffman, Jane Mwangi, Caroline Wambua, Elizabeth Kagotho, Angela Amayo, Peter Ojwang, Zulfiqarali Premji, Kiyoshi Ichihara and Rajiv Erasmus

Factors associated with diabetes-related distress over time among patients with T2DM in a tertiary hospital in Singapore

Persistent diabetes-related distress (DRD) is experienced by patients with Type 2 Diabetes Mellitus. Knowing factors associated with persistent DRD will aid clinicians in prioritising interventions efforts.

Authors: Maudrene L. Tan, Chuen S. Tan, Konstadina Griva, Yung S. Lee, Jeannette Lee, E. S. Tai, Eric Y. Khoo and Hwee-Lin Wee

Acute airway compromise due to parathyroid tumour apoplexy: an exceptionally rare and potentially life-threatening presentation

Spontaneous haemorrhage into a parathyroid adenoma is a rare and potentially life-threatening presentation.

Authors: Aoife Garrahy, David Hogan, James Paul O’Neill and Amar Agha

Use of social adaptability index to explain self-care and diabetes outcomes

To examine whether the social adaptability index (SAI) alone or components of the index provide a better explanatory model for self-care and diabetes outcomes.

Authors: Jennifer A. Campbell, Rebekah J. Walker, Brittany L. Smalls and Leonard E. Egede

Communication with young people in paediatric and adult endocrine consultations: an intervention development and feasibility study

Communication is complex in endocrine care, particularly during transition from paediatric to adult services. The aims of this study were to examine the feasibility of interventions to support young people to ...

Authors: J. Downing, H. Gleeson, P.E. Clayton, J.R.E. Davis, P. Dimitri, J. Wales, B. Young and P. Callery

Quality measure and weight loss assessment in patients with type 2 diabetes mellitus treated with canagliflozin or dipeptidyl peptidase-4 inhibitors

Achieving control of glycated hemoglobin (HbA1c), blood pressure (BP), and body weight (BW) remains a challenge for most patients with type 2 diabetes mellitus (T2DM). In clinical trials, canagliflozin (CANA),...

Authors: Carol H. Wysham, Patrick Lefebvre, Dominic Pilon, Mike Ingham, Marie-Hélène Lafeuille, Bruno Emond, Rhiannon Kamstra, Wing Chow, Michael Pfeifer and Mei Sheng Duh

Trends in sex differences in the receipt of quality of care indicators among adults with diabetes: United States 2002-2011

Evidence suggests disparities in quality of care (QoC) indicators based on sex exist in adults diagnosed with diabetes; however, this research is limited. Therefore, the objective of this research study was to...

Authors: Joni S. Williams, Kinfe G. Bishu, Alessandra St. Germain and Leonard E. Egede

Patterns, control and complications of diabetes from a hospital based registry established in a low income country

Diabetes registry enables practitioners to measure the characteristics and patterns of diabetes across their patient population. They also provide insight into practice patterns which can be very effective in ...

Authors: Jaweed Akhter, Asma Ahmed, Minaz Mawani, Laila Lakhani, Ayaz Kalsekar, Shehla Tabassum and Najmul Islam

Factors associated with impaired color vision without retinopathy amongst people with type 2 diabetes mellitus: a cross-sectional study

Patients with type 2 diabetes mellitus (T2DM) may develop color vision impairment. This study aimed to determine the prevalence and factors associated with impaired color vision in patients with T2DM but witho...

Authors: N. C. Tan, W. F. Yip, S. Kallakuri, U. Sankari and Y. L. E. Koh

Association of calf circumference with insulin resistance and non-alcohol fatty liver disease: the REACTION study

The feature of nonalcoholic fatty liver disease (NAFLD) is pathological excessive liver lipid accumulation of subjects who without history of alcohol abuse. Calf circumference is a proxy for lower-body fat and...

Authors: Weiwei Zhang, Zhen Yang, Yixin Niu, Xiaoyong Li, Lingfei Zhu, Shuai Lu, Hongmei Zhang, Jiangao Fan, Guang Ning, Li Qin and Qing Su

Pulse wave velocity and cardiac autonomic function in type 2 diabetes mellitus

Increased carotid-femoral pulse wave velocity (PWV) has been associated with incident cardiovascular disease, independently of traditional risk factors. Cardiac autonomic dysfunction is a common complication o...

Authors: Stamatina Chorepsima, Ioanna Eleftheriadou, Anastasios Tentolouris, Ioannis Moyssakis, Athanasios Protogerou, Alexandros Kokkinos, Petros P. Sfikakis and Nikolaos Tentolouris

Androsterone glucuronide to dehydroepiandrosterone sulphate ratio is discriminatory for obese Caucasian women with polycystic ovary syndrome

Androsterone glucuronide (ADTG) concentrations have been suggested as a marker of the effects of androgens at the target tissue level. As the mechanism for hyperandrogenemia in obese and nonobese polycystic ov...

Authors: Li-Wei Cho, Thozhukat Sathyapalan, Eric S Kilpatrick, Brian G Keevil, Adrian G Miller, Anne M Coady, Lina Ahmed and Stephen L Atkin

Age differences in diabetes-related complications and glycemic control

This study aimed to examine the associations of age with the presence of complications and glycemic control in the Northwest of Iran.

Authors: S. M. Shamshirgaran, A. Mamaghanian, A. Aliasgarzadeh, N. Aiminisani, M. Iranparvar-Alamdari and J. Ataie

Does left ventricular hypertrophy affect cognition and brain structural integrity in type 2 diabetes? Study design and rationale of the Diabetes and Dementia (D2) study

Cognitive impairment is common in type 2 diabetes mellitus, and there is a strong association between type 2 diabetes and Alzheimer’s disease. However, we do not know which type 2 diabetes patients will dement...

Authors: Sheila K. Patel, Carolina Restrepo, Emilio Werden, Leonid Churilov, Elif I. Ekinci, Piyush M. Srivastava, Jay Ramchand, Bryan Wai, Brian Chambers, Christopher J. O’Callaghan, David Darby, Vladimir Hachinski, Toby Cumming, Geoff Donnan, Louise M. Burrell and Amy Brodtmann

Assessment of platelets morphological changes and serum butyrylcholinesterase activity in children with diabetic ketoacidosis: a case control study

Many studies indicated that mean platelet volume (MPV) and platelet distribution width (PDW) may be valuable in the diagnosis and management of clinical disorders; also, serum butyrylcholinesterase activity (B...

Authors: Suzan Omar Mousa, Samira Zein Sayed, Mahmoud Mohammed Moussa and Ahmed Hamdy Hassan

The effectiveness of a value-based EMOtion-cognition-Focused educatIonal programme to reduce diabetes-related distress in Malay adults with Type 2 diabetes (VEMOFIT): study protocol for a cluster randomised controlled trial

Type 2 diabetes mellitus (T2DM) patients experience many psychosocial problems related to their diabetes. These often lead to emotional disorders such as distress, stress, anxiety and depression, resulting in ...

Authors: Boon-How Chew, Rimke C. Vos, Sazlina Shariff Ghazali, Nurainul Hana Shamsuddin, Aaron Fernandez, Firdaus Mukhtar, Mastura Ismail, Azainorsuzila Mohd Ahad, Narayanan N. Sundram, Siti Zubaidah Mohd Ali and Guy E. H. M. Rutten

Erratum to: Reference intervals for thyroid stimulating hormone and free thyroxine derived from neonates undergoing routine screening for congenital hypothyroidism at a university teaching hospital in Nairobi, Kenya: a cross sectional study

Authors: Geoffrey Omuse, Ali Kassim, Francis Kiigu, Syeda Ra’ana Hussain and Mary Limbe

Adherence to and factors associated with self-care behaviours in type 2 diabetes patients in Ghana

Previous research has failed to examine more than one self-care behaviour in type 2 diabetes patients in Ghana. The purpose of this study is to investigate adult Ghanaian type 2 diabetes patients’ adherence to...

Authors: Victor Mogre, Zakaria Osman Abanga, Flora Tzelepis, Natalie A. Johnson and Christine Paul

The incidence of diabetes mellitus and diabetic retinopathy in a population-based cohort study of people age 50 years and over in Nakuru, Kenya

The epidemic rise of diabetes carries major negative public health and economic consequences particularly for low and middle-income countries. The highest predicted percentage growth in diabetes is in the sub-...

Authors: Andrew Bastawrous, Wanjiku Mathenge, Kevin Wing, Madeleine Bastawrous, Hillary Rono, Helen A. Weiss, David Macleod, Allen Foster, Tunde Peto, Peter Blows, Matthew Burton and Hannah Kuper

Impaired lung function is associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in middle-aged and elderly Chinese

Associations between lung function and non-alcoholic fatty liver disease (NAFLD) have been reported. However, evidence from large-scale populations about the relationship is scarce. The objective of the study ...

Authors: Li Qin, Weiwei Zhang, Zhen Yang, Yixin Niu, Xiaoyong Li, Shuai Lu, Yin Xing, Ning Lin, Hongmei Zhang, Guang Ning, Jiangao Fan and Qing Su

Two novel LHX3 mutations in patients with combined pituitary hormone deficiency including cervical rigidity and sensorineural hearing loss

Congenital combined pituitary hormone deficiency (CPHD) is a rare heterogeneous group of conditions. CPHD-type 3 (CPHD3; MIM# 221750) is caused by recessive mutations in LHX3, a LIM-homeodomain transcription fact...

Authors: Khushnooda Ramzan, Bassam Bin-Abbas, Lolwa Al-Jomaa, Rabab Allam, Mohammed Al-Owain and Faiqa Imtiaz

Prevalence and determinants of erectile dysfunction among diabetic patients attending in hospitals of central and northwestern zone of Tigray, northern Ethiopia: a cross-sectional study

The prevalence of erectile dysfunction among diabetic men varies between 35–90%. Although erectile dysfunction is widespread among men with diabetes, the condition often remains undiagnosed and demands appropr...

Authors: Awole Seid, Hadgu Gerensea, Shambel Tarko, Yosef Zenebe and Rahel Mezemir

The association between biochemical control and cardiovascular risk factors in acromegaly

The study aim was to estimate the proportion of acromegaly patients with various comorbidities and to determine if biochemical control was associated with reduced proportion of cardiovascular risk factors.

Authors: John D. Carmichael, Michael S. Broder, Dasha Cherepanov, Eunice Chang, Adam Mamelak, Qayyim Said, Maureen P. Neary and Vivien Bonert

Extended clinical features associated with novel Glis3 mutation: a case report

Mutations in the GLI-similar 3 (GLIS3) gene encoding the transcription factor GLIS3 are a rare cause of neonatal diabetes and congenital hypothyroidism with 12 reported patients to date. Additional features, p...

Authors: K. A. Alghamdi, A. B. Alsaedi, A. Aljasser, A. Altawil and Naglaa M. Kamal

Berberine improves glucogenesis and lipid metabolism in nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is considered a critical hepatic manifestation of metabolic syndrome. Berberine (BBR) exerts anti-hyperglycemic and anti-dyslipidemic effects and can also ameliorate NA...

Authors: Li Zhao, Zhen Cang, Honglin Sun, Xiaomin Nie, Ningjian Wang and Yingli Lu