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  1. The Space GlucoseControl system (SGC) is a nurse-driven, computer-assisted device for glycemic control combining infusion pumps with the enhanced Model Predictive Control algorithm (B. Braun, Melsungen, German...

    Authors: Karin Amrein, Norman Kachel, Heike Fries, Roman Hovorka, Thomas R Pieber, Johannes Plank, Urs Wenger, Barbara Lienhardt and Marco Maggiorini
    Citation: BMC Endocrine Disorders 2014 14:62
  2. The purpose of this analysis is to evaluate the safety and effectiveness of insulin initiation with once-daily insulin detemir (IDet) or insulin glargine (IGlar) in real-life clinical practice in Turkish patie...

    Authors: Taner Damci, Rifat Emral, Anne Louise Svendsen, Tanzer Balkir and Jiten Vora
    Citation: BMC Endocrine Disorders 2014 14:61
  3. It is not clear to what extent educational programs aimed at promoting diabetes self-management in ethnic minority groups are effective. The aim of this work was to systematically review the effectiveness of e...

    Authors: Ignacio Ricci-Cabello, Isabel Ruiz-Pérez, Antonio Rojas-García, Guadalupe Pastor, Miguel Rodríguez-Barranco and Daniela C Gonçalves
    Citation: BMC Endocrine Disorders 2014 14:60
  4. Besides the classical role of vitamin D on calcium and bone homeostasis, vitamin D deficiency has recently been identified as a contributing factor in the onset of insulin resistance in type 2 diabetes mellitu...

    Authors: Yvonne HM Krul-Poel, Hans van Wijland, Frank Stam, Edwin ten Boekel, Paul Lips and Suat Simsek
    Citation: BMC Endocrine Disorders 2014 14:59
  5. α-amidation is a final, essential step in the biosynthesis of about half of all peptide hormones and neurotransmitters. Peptidylglycine α-amidating monooxygenase (PAM), with enzymatic domains that utilize Cu a...

    Authors: Eric D Gaier, Alison Kleppinger, Martina Ralle, Jonathan Covault, Richard E Mains, Anne M Kenny and Betty A Eipper
    Citation: BMC Endocrine Disorders 2014 14:58
  6. Despite the consistent relationship between serum γ-glutamyltransferase (GGT) and type 2 diabetes (T2D), one unsolved issue is the role of serum GGT in the well-known association between obesity and T2D. This ...

    Authors: Nam Soo Hong, Jeong-Gook Kim, Yu-Mi Lee, Hyun-Woo Kim, Sin Kam, Keon-Yeop Kim, Ki-Su Kim and Duk-Hee Lee
    Citation: BMC Endocrine Disorders 2014 14:57
  7. An aging population means that chronic illnesses, such as diabetes, are becoming more prevalent and demands for care are rising. Members of primary care teams should organize and coordinate patient care with a...

    Authors: Alessandra Buja, Rosa Gini, Modesta Visca, Gianfranco Damiani, Bruno Federico, Daniele Donato, Paolo Francesconi, Alessandro Marini, Andrea Donatini, Salvatore Brugaletta, Giorgia Bardelle, Vincenzo Baldo and Mariadonata Bellentani
    Citation: BMC Endocrine Disorders 2014 14:56
  8. Advanced glycation endproducts (AGEs) contribute to the development of vascular complications of diabetes and have been recently implicated in the pathogenesis of diabetes. Since AGEs are generated within food...

    Authors: Nicole J Kellow, Melinda T Coughlan, Gayle S Savige and Christopher M Reid
    Citation: BMC Endocrine Disorders 2014 14:55
  9. Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are rare neuroendocrine tumors, and lack of data in Asian populations especially in China. The aim of this retrospective study was to assess the clini...

    Authors: Xianbin Zhang, Li Ma, Haidong Bao, Jing Zhang, Zhongyu Wang and Peng Gong
    Citation: BMC Endocrine Disorders 2014 14:54
  10. Oral medication for patients with type 2 diabetes mellitus plays an important role in diabetes care and is associated with a high level self-care behavior and self-management. However, poor adherence to diabet...

    Authors: Sunya-Lee Antoine, Dawid Pieper, Tim Mathes and Michaela Eikermann
    Citation: BMC Endocrine Disorders 2014 14:53
  11. Promyelocytic leukaemia zinc finger (PLZF) is a transcriptional repressor that was originally isolated from a patient with promyelocytic leukaemia. PLZF also affects key elements for cell cycle progression, su...

    Authors: Kazuhiko Matsuzawa, Shoichiro Izawa, Tsuyoshi Ohkura, Hiroko Ohkura, Kiyosuke Ishiguro, Akio Yoshida, Yumi Takiyama, Masakazu Haneda, Chiaki Shigemasa, Kazuhiro Yamamoto and Shin-ichi Taniguchi
    Citation: BMC Endocrine Disorders 2014 14:52
  12. Cushing’s syndrome results from exposure to excess glucocorticoids. Ectopic Cushings is endogenous ACTH dependant form of Cushing’s associated with markedly raised ACTH and cortisol levels. This leads to an im...

    Authors: Azra Rizwan, Aqiba Sarfaraz, Abdul Jabbar, Jaweed Akhter and Najmul Islam
    Citation: BMC Endocrine Disorders 2014 14:51
  13. Obesity and diabetes mellitus are well-defined risk factors for cardiovascular mortality. The impact of antecedent hyperglycemia and body size on mortality in critical ill patients in intensive care units (ICU...

    Authors: Marina Verçoza Viana, Rafael Barberena Moraes, Amanda Rodrigues Fabbrin, Manoella Freitas Santos, Vanessa Bielefeldt Leotti Torman, Silvia Regina Vieira, Jorge Luiz Gross, Luis Henrique Canani and Fernando Gerchman
    Citation: BMC Endocrine Disorders 2014 14:50
  14. Hypoglycemic episodes are infrequent in individuals without a history of diabetes mellitus or bariatric surgery. When hypoglycemia does occur in such individuals, an uncommon but important diagnosis to conside...

    Authors: Ameer Khowaja, Brianna Johnson-Rabbett, John Bantle and Amir Moheet
    Citation: BMC Endocrine Disorders 2014 14:49
  15. In patients with type 2 diabetes, chronic kidney disease (CKD) is associated with increased risk of hypoglycaemia and death. Yet, it remains uncertain whether hypoglycaemia-associated mortality is modified by ...

    Authors: Alice PS Kong, Xilin Yang, Andrea Luk, Kitty KT Cheung, Ronald CW Ma, Wing Yee So, Chung Shun Ho, Michael HM Chan, Risa Ozaki, Chun Chung Chow, Nicola Brown and Juliana CN Chan
    Citation: BMC Endocrine Disorders 2014 14:48
  16. Obesity and gestational diabetes (GDM) in pregnancy are recognized risk factors for adverse outcomes, including cesarean section (CS), macrosomia and preeclampsia. The aim of this study was to investigate the ...

    Authors: Hayfaa A Wahabi, Amel A Fayed, Rasmieh A Alzeidan and Ahmed A Mandil
    Citation: BMC Endocrine Disorders 2014 14:47
  17. Mexican Americans are at an increased risk of both thyroid dysfunction and metabolic syndrome (MS). Thus it is conceivable that some components of the MS may be associated with the risk of thyroid dysfunction ...

    Authors: Manju Mamtani, Hemant Kulkarni, Thomas D Dyer, Laura Almasy, Michael C Mahaney, Ravindranath Duggirala, Anthony G Comuzzie, Paul B Samollow, John Blangero and Joanne E Curran
    Citation: BMC Endocrine Disorders 2014 14:46
  18. 11 patients were referred to our Molecular Genetics Department at the Royal Devon and Exeter Hospital between 2000-2012 with a physician’s diagnosis of remitting diabetes. Our aim was to identify patients with...

    Authors: Tarig Babiker, Ali J Chakera, Maggie Shepherd and Andrew T Hattersley
    Citation: BMC Endocrine Disorders 2014 14:45
  19. Quantifying the burden of diabetes mellitus is fundamental for managing patients in health service delivery systems and improves the understanding of the importance of prevention and early intervention of diab...

    Authors: Carola A Huber, Matthias Schwenkglenks, Roland Rapold and Oliver Reich
    Citation: BMC Endocrine Disorders 2014 14:44
  20. Testicular morphology and immunohistochemical studies have never been reported in genetically documented adult patients with 5 alpha-reductase type 2 deficiency (5α-R2 deficiency).

    Authors: Lavinia Vija, Sophie Ferlicot, Diana Paun, Hélène Bry-Gauillard, Gabriela Berdan, Issam Abd-Alsamad, Marc Lombès and Jacques Young
    Citation: BMC Endocrine Disorders 2014 14:43
  21. Although chronic adrenocorticotropic hormone (ACTH) and androgen hyperstimulation are assumed to be involved in the pathogenesis of adrenal myelolipomas associated with poor-compliance patients with congenital...

    Authors: Madson Q Almeida, Laura C Kaupert, Luciana P Brito, Antonio M Lerario, Beatriz M P Mariani, Marta Ribeiro, Osmar Monte, Francisco T Denes, Berenice B Mendonca and Tânia ASS Bachega
    Citation: BMC Endocrine Disorders 2014 14:42
  22. Previously considered as a disease of the affluent, west or urban people and not of public health importance, diabetes mellitus is increasingly becoming a significant cause of morbidity and mortality in sub-Sahar...

    Authors: Kelias Phiri Msyamboza, Chimwemwe J Mvula and Damson Kathyola
    Citation: BMC Endocrine Disorders 2014 14:41
  23. Increased morbidity and mortality associated with conventional glucocorticoid replacement therapy for primary adrenal insufficiency (primary AI; estimated prevalence 93–140/million), secondary AI (estimated pr...

    Authors: Bertil Ekman, David Fitts, Claudio Marelli, Robert D Murray, Marcus Quinkler and Pierre MJ Zelissen
    Citation: BMC Endocrine Disorders 2014 14:40
  24. Few studies have examined young adults with type 1 diabetes use of health services and the development of vascular complications. As part of the Youth Outreach for Diabetes (YOuR-Diabetes) project, this study ...

    Authors: Steven James, Lin Perry, Robyn Gallagher, Julia Lowe, Janet Dunbabin, Patrick McElduff, Shamasunder Acharya and Katharine Steinbeck
    Citation: BMC Endocrine Disorders 2014 14:39
  25. Central precocious puberty (CPP) and phenylketonuria (PKU) are two rare conditions, the latter being the rarer. To date, only one case featuring both these conditions has been reported, and hyperphenylalaninem...

    Authors: Laura Lucaccioni, Bernd C Schwahn, Malcolm Donaldson and Claudio Giacomozzi
    Citation: BMC Endocrine Disorders 2014 14:38
  26. Canagliflozin is a sodium glucose co-transporter 2 inhibitor developed for the treatment of patients with type 2 diabetes mellitus (T2DM). The efficacy and safety of canagliflozin were evaluated in patients wi...

    Authors: Alan Sinclair, Bruce Bode, Stewart Harris, Ujjwala Vijapurkar, Cristiana Mayer, Albert Fung, Wayne Shaw, Keith Usiskin, Mehul Desai and Gary Meininger
    Citation: BMC Endocrine Disorders 2014 14:37
  27. Insulin aspart (IAsp) and its biphasic preparations BIAsp50 and BIAsp70 (containing 50% and 70% IAsp, respectively) have distinct glucose-lowering properties as compared to human insulin (HI). We investigated ...

    Authors: Zhulin Ma, Jens Sandahl Christiansen, Torben Laursen, Chunsen Wu, Torsten Lauritzen, Tina Parkner and Jan Frystyk
    Citation: BMC Endocrine Disorders 2014 14:35
  28. Osmotic demyelination syndrome (ODS) may be observed as a result of a rapid change in serum osmolarity, such as that induced by an overly rapid correction of serum sodium levels in hyponatraemic patients.

    Authors: Giovanni Corona, Luigi Simonetti, Corinna Giuliani, Alessandra Sforza and Alessandro Peri
    Citation: BMC Endocrine Disorders 2014 14:34
  29. Increased risk of osteoporosis and its clinical significance in patients with diabetes is controversial. We analyze osteoporosis prevalence and determinants of bone mineral density (BMD) in patients with type ...

    Authors: Gudrun Leidig-Bruckner, Sonja Grobholz, Thomas Bruckner, Christa Scheidt-Nave, Peter Nawroth and Jochen G Schneider
    Citation: BMC Endocrine Disorders 2014 14:33
  30. Seminomas have been rarely associated with malignant hypercalcemia. The responsible mechanism of hypercalcemia in this setting has been described to be secondary to 1,25-dihydroxyvitamin D secretion. The relat...

    Authors: René Rodríguez-Gutiérrez, Maria Azucena Zapata-Rivera, Dania Lizeth Quintanilla-Flores, Carlos Rodrigo Camara-Lemarroy, Fernando Javier Lavalle-Gonzalez, José Gerardo González-González and Jesús Zacarías Villarreal-Pérez
    Citation: BMC Endocrine Disorders 2014 14:32
  31. Diabetes education and self-care remains the cornerstone of diabetes management. There are many structured diabetes modules available in the United Kingdom, Europe and United States of America. Contrastingly, ...

    Authors: Badariah Ahmad, Amutha Ramadas, Quek Kia Fatt and Anuar Zaini Md Zain
    Citation: BMC Endocrine Disorders 2014 14:31
  32. Continuous intraperitoneal insulin infusion (CIPII) with an implantable pump is a treatment option for patients with type 1 diabetes mellitus (T1DM). Aim of the present study was to describe the long-term cour...

    Authors: Peter R van Dijk, Susan JJ Logtenberg, Klaas H Groenier, Rijk OB Gans, Nanne Kleefstra and Henk JG Bilo
    Citation: BMC Endocrine Disorders 2014 14:30
  33. Aldosterone synthase (CYP11B2) deficiency is a rare autosomal recessive disorder, usually presenting with severe salt-wasting in infancy or stress-induced hyperkalaemia and postural hypotension in adulthood. Neon...

    Authors: Elaine Hui, Matthew CW Yeung, Pik To Cheung, Elaine Kwan, Louis Low, Kathryn CB Tan, Karen SL Lam and Angel OK Chan
    Citation: BMC Endocrine Disorders 2014 14:29
  34. The effects of brain natriuretic peptide (BNP) on the risk of cardiovascular disease and atherosclerosis have been studied. However, little information is available regarding peripheral arterial disease (PAD),...

    Authors: Qi-hui Jin, Wan-lan Ye, Huai-hong Chen, Xiao-jun He, Tian-lang Li, Qiang Liu, Liang Zhong, Lei Xu and Chun-mao Han
    Citation: BMC Endocrine Disorders 2014 14:27
  35. Hand-foot syndrome (HFS), also known as palmar-plantar Erythrodysesthesia (PPE), acral erythema or Burgdorf reaction, is a dermatologic toxic reaction to certain chemotherapies, including sorafenib. A high inc...

    Authors: Carlos Velandia-Carrillo, Edwin Wandurraga-Sánchez and Diego Gómez-Abreo
    Citation: BMC Endocrine Disorders 2014 14:26
  36. To study hormonal changes associated with severe hyperglycemia in critically ill children and the relationship with prognosis and length of stay in intensive care.

    Authors: Yolanda Ballestero, Jesús López-Herce, Rafael González, Maria José Solana, Jimena del Castillo, Javier Urbano, Marta Botran, Ana García, Nieves López and Jose María Bellón
    Citation: BMC Endocrine Disorders 2014 14:25
  37. The editors of BMC Endocrine Disorders would like to thank all our reviewers who have contributed to the journal in Volume 13 (2013).

    Authors: Tim Shipley
    Citation: BMC Endocrine Disorders 2014 14:15
  38. The purpose of this study was to evaluate the association between blood manganese levels and the prevalence of chronic diseases in the Korean population.

    Authors: Eun Sil Koh, Sung Jun Kim, Hye Eun Yoon, Jong Hee Chung, Sungjin Chung, Cheol Whee Park, Yoon Sik Chang and Seok Joon Shin
    Citation: BMC Endocrine Disorders 2014 14:24
  39. The aim of the present study is to examine the clinical indices related to cardiovascular risk management of Greek patients with type 2 diabetes, before and after the major economic crisis that emerged in the ...

    Authors: Stavros Liatis, Stavroula Papaoikonomou, Asimina Ganotopoulou, Athanasia Papazafiropoulou, Constantinos Dinos, Marios Michail, Apostolos Xilomenos, Andreas Melidonis and Stavros Pappas
    Citation: BMC Endocrine Disorders 2014 14:23
  40. Due to ongoing rise in need for care for people with chronic diseases and lagging increase in number of care providers, alternative forms of care provision and self-management support are needed. Empowering pa...

    Authors: Yvonne Roelofsen, Steven H Hendriks, Floor Sieverink, Michael van Vugt, Kornelis JJ van Hateren, Frank J Snoek, Maartje de Wit, Rijk OB Gans, Klaas H Groenier, Julia EWC van Gemert-Pijnen, Nanne Kleefstra and Henk JG Bilo
    Citation: BMC Endocrine Disorders 2014 14:22
  41. Many type 2 diabetes mellitus patients face difficulties self-managing their illness, which can lead to high levels of diabetes-related distress. Diabetes distress may be decreased by peer support, as peers un...

    Authors: Lianne de Vries, Amber AWA van der Heijden, Esther van 't Riet, Caroline A Baan, Piet J Kostense, Mieke Rijken, Guy EHM Rutten and Giel Nijpels
    Citation: BMC Endocrine Disorders 2014 14:21
  42. Diabetic retinopathy (DR) is one of the leading causes for complete loss of vision among working-aged adults around the world. The present study aims to evaluate the rate of DR and its risk factors among the a...

    Authors: Prasad Katulanda, Yasindu C Waniganayake, Priyanga Ranasinghe, WM Udai Akalanka Wijetunga, Mahesh Jayaweera, Nishantha P Wijesinghe, Rezvi Sheriff and David R Matthews
    Citation: BMC Endocrine Disorders 2014 14:20
  43. Hyperglycemia induces chromatin remodeling with consequences on differential gene expression in mouse hepatocytes, similar to what occurs during aging. The liver is the central organ for the regulation of gluc...

    Authors: Flávia G Ghiraldini, André B Silveira, Dirk A Kleinjan, Nick Gilbert and Maria Luiza S Mello
    Citation: BMC Endocrine Disorders 2014 14:19
  44. Hyperhomocysteinemia is a well-known cardiovascular risk factor and its elevation is established in overt hypothyroidism. Since some authors suggest that chronic autoimmune thyroiditis per se may be considered...

    Authors: Maciej Owecki, Jolanta Dorszewska, Nadia Sawicka-Gutaj, Anna Oczkowska, Michał K Owecki, Michał Michalak, Jakub Fischbach, Wojciech Kozubski and Marek Ruchała
    Citation: BMC Endocrine Disorders 2014 14:18
  45. To compare the safety and efficacy of saxagliptin 2.5 mg twice daily (BID) versus placebo add-on therapy to metformin immediate release (IR) in patients with type 2 diabetes and inadequate glycemic control wit...

    Authors: Judith L White, Patricia Buchanan, Jia Li and Robert Frederich
    Citation: BMC Endocrine Disorders 2014 14:17
  46. Aromatase deficiency is a rare, autosomal recessive disorder of which there are approximately twenty four case reports. The aromatase enzyme is crucial in the biosynthesis of oestrogens from androgens. The phe...

    Authors: Lucia Gagliardi, Hamish S Scott, Jinghua Feng and David J Torpy
    Citation: BMC Endocrine Disorders 2014 14:16
  47. The possible association between metabolic syndrome (MS) and bone mineral density (BMD) has been highlighted recently. However, the exact effects of MS on calcaneal quantitative ultrasound (QUS) parameters rem...

    Authors: Min Sun, Mengdie Cao, Qi Fu, Zhenxin Zhu, Chuchen Meng, Jia Mao, Yun Shi, Yu Duan, Wei Tang, Xiaoping Huang, Wei He and Tao Yang
    Citation: BMC Endocrine Disorders 2014 14:14
  48. Emerging epidemiological evidence suggest an association between metabolic syndrome and fractures. However, whether metabolic syndrome is an independent risk or protective factor of fractures remains controver...

    Authors: Kan Sun, Jianmin Liu, Nan Lu, Hanxiao Sun and Guang Ning
    Citation: BMC Endocrine Disorders 2014 14:13

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