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  1. Radioactive iodine (RAI) therapy is an important treatment option for Graves’ disease (GD), the main side effect of RAI treatment is hypothyroidism, and the factors resulting in hypothyroidism are still contro...

    Authors: Rui-Ting Hu, De-Shan Liu and Bin Li

    Citation: BMC Endocrine Disorders 2020 20:76

    Content type: Research article

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  2. Nonalcoholic fatty liver disease (NAFLD) is a multisystem disease that affects the liver and a variety of extra-hepatic organ systems. This study aimed to investigate the relationship between hepatic steatosis...

    Authors: Lijun Hu, Xiaoliang Shao, Chun Qiu, Xiaonan Shao, Xiaosong Wang, Rong Niu and Yuetao Wang

    Citation: BMC Endocrine Disorders 2020 20:75

    Content type: Research article

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  3. DAX1 mutations are related to the X-linked form of adrenal hypoplasia congenita (AHC) in infancy and to hypogonadotropic hypogonadism (HH) in puberty. We report a male patient affected by X-linked AHC who present...

    Authors: Boo Kyeong Seo, Seul Ah. Jeong, Jae Young Cho, Ji Sook Park, Ji-Hyun Seo, Eun Sil Park, Jae-Young Lim, Hyang-Ok Woo and Hee-Shang Youn

    Citation: BMC Endocrine Disorders 2020 20:73

    Content type: Case report

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  4. We quantified, among diabetic adults, the frequency, costs, and factors associated with visits to the emergency department (EDs) and subsequent hospitalizations for acute hypoglycaemic and hyperglycaemic events.

    Authors: Anita Andreano, Marco Bosio and Antonio Giampiero Russo

    Citation: BMC Endocrine Disorders 2020 20:72

    Content type: Research article

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  5. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of childbearing age. This study aimed to compare the effects of lifestyle interventions on anthropometric, clinical, and biochemi...

    Authors: Somayeh Abdolahian, Fahimeh Ramezani Tehrani, Mina Amiri, Delaram Ghodsi, Razieh Bidhendi Yarandi, Mahdi Jafari, Hamid Alavi Majd and Fatemeh Nahidi

    Citation: BMC Endocrine Disorders 2020 20:71

    Content type: Research article

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  6. P-selectin, encoded by SELP, has been implicated as an important molecule in the development of arterial stiffness, consequently leading to vascular complications in T2DM. SELP polymorphisms and increased levels ...

    Authors: Raminderjit Kaur, Jatinder Singh, Rohit Kapoor and Manpreet Kaur

    Citation: BMC Endocrine Disorders 2020 20:70

    Content type: Research article

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  7. Metabolic syndrome (MetS) is one of the main public health problems worldwide. Although some relations between dietary intakes and MetS have been found, few studies have focused on association between dietary ...

    Authors: Mahdi Vajdi, Mahdieh Abbasalizad Farhangi and Leila Nikniaz

    Citation: BMC Endocrine Disorders 2020 20:69

    Content type: Research article

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  8. Surgical resection of prolactinomas resistant to dopamine agonists is frequently incomplete due to fibrotic changes of the tumour under pharmacological therapy. In order to identify a subgroup of patients who ...

    Authors: Elle Vermeulen, Jean D’Haens, Tadeusz Stadnik, David Unuane, Kurt Barbe, Vera Van Velthoven and Sven Gläsker

    Citation: BMC Endocrine Disorders 2020 20:68

    Content type: Research article

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  9. Insulin resistance (IR) is a common characteristic of women with polycystic ovary syndrome (PCOS). It has been reported that circulating Fetuin-A levels were associated with IR and type 2 diabetes mellitus (T2...

    Authors: Sha Liu, Wenjing Hu, Yirui He, Ling Li, Hua Liu, Lin Gao, Gangyi Yang and Xin Liao

    Citation: BMC Endocrine Disorders 2020 20:67

    Content type: Research article

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  10. The aim of this study was to estimate the levels of circulating carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in subjects with gestational diabetes mellitus (GDM) and investigate the rela...

    Authors: Yiming Wu, Zhen Yang, Lingfei Zhu, Qing Su and Li Qin

    Citation: BMC Endocrine Disorders 2020 20:66

    Content type: Research article

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  11. Vitamin D measurement is a composite of vitamin D2 (25(OH)D2) and D3 (25(OH)D3) levels, and its deficiency is associated with the development of type 2 diabetes (T2DM) and diabetic complications; vitamin D defici...

    Authors: Lina H. M. Ahmed, Alexandra E. Butler, Soha R. Dargham, Aishah Latif, Amal Robay, Omar M. Chidiac, Amin Jayyousi, Jassim Al Suwaidi, Ronald G. Crystal, Stephen L. Atkin and Charbel Abi Khalil

    Citation: BMC Endocrine Disorders 2020 20:65

    Content type: Research article

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  12. Hereditary medullary thyroid carcinoma (MTC) is mainly caused by germline mutations in the RET proto-oncogene, which accounts for 20–30% of all MTC according to foreign studies. However, no English literatures...

    Authors: Qin Huang, Aihua Hu and Mingsheng Zhang

    Citation: BMC Endocrine Disorders 2020 20:64

    Content type: Case report

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  13. Prediabetes is associated with a high risk of colon cancer, and abdominal obesity, which can result in the secretion of several obesity-related adipocytokines, is an independent influencing factor for colonic ...

    Authors: Lili Deng, Xiaotong Zhao, Mingwei Chen, Hua Ji, Qunhui Zhang, Ruofei Chen and Yalei Wang

    Citation: BMC Endocrine Disorders 2020 20:63

    Content type: Research article

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  14. Pregnancy-induced Cushing’s syndrome (CS) with an adrenocortical adenoma overexpressing luteinizing hormone (LH)/human choriogonadotropin (hCG) receptors (LHCGR) has been rarely reported in the literatures. Th...

    Authors: Shaohua Li, Chen Yang, Jing Fan, Yao Yao, Xiaomei Lv, Ying Guo and Shaoling Zhang

    Citation: BMC Endocrine Disorders 2020 20:62

    Content type: Case report

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  15. Cardiac damage triggered by severe hypocalcemia is well known. However, the role of chronic hypoparathyroidism (HP) and pseudohypoparathyroidism (PHP) in cardiac health is still unclear. We investigated the ef...

    Authors: Yabing Wang, Kun He, Ou Wang, Xue Lin, Sixing Chen, Yan Jiang, Mei Li, Weibo Xia and Xiaoping Xing

    Citation: BMC Endocrine Disorders 2020 20:61

    Content type: Research article

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  16. Non-islet cell tumor hypoglycemia (NICTH) is a rare paraneoplastic syndrome that secretes incompletely processed high molecular weight insulin growth factor 2 (big-IGF2), which results in stimulation of the in...

    Authors: Haruka Yamasaki, Ayako Itawaki, Miwa Morita, Hitomi Miyake, Masahiro Yamamoto, Hiroki Sonoyama, Sayuri Tanaka, Masakazu Notsu, Mika Yamauchi, Yusuke Fujii, Noriyoshi Ishikawa, Izumi Fukuda, Shunji Ishihara and Keizo Kanasaki

    Citation: BMC Endocrine Disorders 2020 20:60

    Content type: Case report

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  17. Polycystic ovary syndrome (PCOS) is a complex multifactorial disorder, affecting millions of women worldwide. The role of genetic polymorphisms of the KISS1 gene on the development of PCOS is still obscure. This ...

    Authors: Maha H. Daghestani, Mazin H. Daghestani, Mamoon Daghistani, Khushboo Ambreen, Fadwa S. Albalawi, Lina M. AlNeghery and Arjumand S. Warsy

    Citation: BMC Endocrine Disorders 2020 20:59

    Content type: Research article

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  18. Glucocorticoid (GC)-induced hyperglycemia is characterized by elevated postprandial blood glucose, which commonly requires multiple insulin injections. We investigated whether a long-acting glucagon-like pepti...

    Authors: Hiroyuki Uchinuma, Masashi Ichijo, Noriyuki Harima and Kyoichiro Tsuchiya

    Citation: BMC Endocrine Disorders 2020 20:58

    Content type: Research article

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  19. Although there are many interventions targeting childhood obesity prevention, only few have demonstrated positive results. The current review aimed to gather and evaluate available school-based intervention st...

    Authors: Christina-Paulina Lambrinou, Odysseas Androutsos, Eva Karaglani, Greet Cardon, Nele Huys, Katja Wikström, Jemina Kivelä, Winne Ko, Ernest Karuranga, Kaloyan Tsochev, Violeta Iotova, Roumyana Dimova, Pilar De Miguel-Etayo, Esther M. González-Gil, Hajnalka Tamás, Zoltán JANCSÓ…

    Citation: BMC Endocrine Disorders 2020 20(Suppl 2):52

    Content type: Review

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    This article is part of a Supplement: Volume 20 Supplement 2

  20. The aim of this paper is to present the development of the Feel4Diabetes Healthy Diet Score and to evaluate its clinical validity.

    Authors: Eeva Virtanen, Jemina Kivelä, Katja Wikström, Christina-Paulina Lambrinou, Pilar De Miguel-Etayo, Nele Huys, Katalin Vraukó-Tóth, Luis A. Moreno, Natalya Usheva, Nevena Chakarova, Sándorné A. Rado, Violeta Iotova, Konstantinos Makrilakis, Greet Cardon, Stavros Liatis, Yannis Manios…

    Citation: BMC Endocrine Disorders 2020 20(Suppl 2):46

    Content type: Research

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    This article is part of a Supplement: Volume 20 Supplement 2

  21. Lanreotide autogel is a somatostatin analog (SSA) approved for the treatment of acromegaly in 73 countries worldwide; however, it is not yet approved in China. The aim of this study was to evaluate the efficac...

    Authors: Zhenmei An, Ting Lei, Lian Duan, Pei Hu, Zhongping Gou, Lihui Zhang, Lucie Durand-Gasselin, Nan Wang, Yan Wang and Feng Gu

    Citation: BMC Endocrine Disorders 2020 20:57

    Content type: Research article

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  22. Satisfactory tools to preclude low-risk patients from intensive diagnostic testing for primary aldosteronism (PA) are lacking. Therefore, we aimed to develop a decision tool to determine which patients with di...

    Authors: Monique E. A. M. van Kleef, Frank L. J. Visseren, Jan Westerink, Michiel L. Bots, Peter J. Blankestijn, Yolanda van der Graaf and Wilko Spiering

    Citation: BMC Endocrine Disorders 2020 20:56

    Content type: Research article

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  23. In 2007, Omnitrope® was the first biosimilar recombinant human growth hormone (rhGH) to be approved in Sweden for treatment in adults and children. Over 10 years’ safety and effectiveness data for biosimilar r...

    Authors: Elena Lundberg, Berit Kriström, Hichem Zouater, Anna Deleskog and Charlotte Höybye

    Citation: BMC Endocrine Disorders 2020 20:55

    Content type: Research article

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  24. Endocrine disorders in patients after heart transplantation (HT) remain understudied. We aimed to assess endocrine profiles and management of HT recipients in the early post- transplant period.

    Authors: Matej Rakusa, Bojan Vrtovec, Gregor Poglajen, Andrej Janez and Mojca Jensterle

    Citation: BMC Endocrine Disorders 2020 20:54

    Content type: Research article

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  25. Primary hyperparathyroidism is a rare condition of disease which can seldomly present as giant retrotrhyroideal cysts, complicating the localization of the adenoma to resect.

    Authors: Christoph Werner, Amelie Lupp, Gabriele Mtuka-Pardon, Christof Kloos, Gunter Wolf, René Aschenbach, Anika Biermann, Martin Freesmeyer and Philipp Seifert

    Citation: BMC Endocrine Disorders 2020 20:53

    Content type: Case report

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  26. The relationship between betatrophin/ANGPTL8 and obesity has been investigated using body mass index (BMI); however, since BMI reflects overall adiposity rather than body fat distribution, it remains unclear w...

    Authors: Jing Zheng, Juan Liu, Beverly S. Hong, Weijian Ke, Minmin Huang and Yanbing Li

    Citation: BMC Endocrine Disorders 2020 20:51

    Content type: Research article

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  27. The prevalence of childhood-onset growth hormone (GH) deficiency (GHD) is estimated to be approximately 1 in 5000 or more, with the cause unknown in most cases (idiopathic isolated GHD). However, additional di...

    Authors: Nami Kojima, Nobuyuki Koriyama, Akinori Tokito, Kazuma Ogiso, Koshi Kusumoto, Satoshi Kubo and Yoshihiko Nishio

    Citation: BMC Endocrine Disorders 2020 20:50

    Content type: Case report

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  28. Diabetes mellitus (DM) is a global health care problem that can impose a substantial economic burden. Diabetic peripheral neuropathy (DPN) is a common microvascular complication of DM that increases the potent...

    Authors: Wondimeneh Shibabaw Shiferaw, Tadesse Yirga Akalu, Yeshamble Work and Yared Asmare Aynalem

    Citation: BMC Endocrine Disorders 2020 20:49

    Content type: Research article

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  29. Fine-needle aspiration cytology (FNAC) has become a well-established modality in the diagnosis, staging and follow-up of thyroid nodules. FNAC outcomes are routinely classified using the Bethesda System for Re...

    Authors: Busra Yaprak Bayrak and Ahmet Tugrul Eruyar

    Citation: BMC Endocrine Disorders 2020 20:48

    Content type: Research article

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  30. Autoimmune polyglandular syndrome type 2 (APS-2) is a rare and complex clinical entity, and little is known about its etiology and progression.

    Authors: Hidefumi Inaba, Hiroyuki Ariyasu, Hiroshi Iwakura, Chiaki Kurimoto, Yoko Ueda, Shinsuke Uraki, Ken Takeshima, Yasushi Furukawa, Shuhei Morita, Yoshiaki Nakayama, Takuya Ohashi, Hidefumi Ito, Yoshiharu Nishimura and Takashi Akamizu

    Citation: BMC Endocrine Disorders 2020 20:47

    Content type: Case report

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  31. Overactivation of renin-aldosterone-angiotensin system (RAS) is part of the pathogenesis of obesity-associated hypertension. Evidences have shown that weight loss can result in reduction in blood pressure and ...

    Authors: Preaw Suwannasrisuk, Patchaya Boonchaya-anant, Natnicha Houngngam, Suthep Udomsawaengsup and Sarat Sunthornyothin

    Citation: BMC Endocrine Disorders 2020 20:45

    Content type: Research article

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  32. Neuroendocrine neoplasms (NENs) display variable behaviors based on origin and grade. We assumed that both tumor origin and the location of metastasis may play a role in survival.

    Authors: Nikolaos A. Trikalinos, Benjamin R. Tan, Manik Amin, Jingxia Liu, Ramaswamy Govindan and Daniel Morgensztern

    Citation: BMC Endocrine Disorders 2020 20:44

    Content type: Research article

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  33. An accurate diagnosis for high-suspicion nodules based on the 2015 American Thyroid Association (ATA) guidelines would reduce unnecessary invasive examinations. Elastography is a useful tool for discriminating...

    Authors: Li Hairu, Peng Yulan, Wang Yan, Ai Hong, Zhou Xiaodong, Yang Lichun, Yan Kun, Xiao Ying, Liu Lisha, Luo Baoming, Yong Qiang, Cong Shuzhen, Jiang Shuangquan, Fu Xin, Ma Buyun, Li Yi…

    Citation: BMC Endocrine Disorders 2020 20:43

    Content type: Research article

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  34. Diabetic foot ulcers (DFUs) are common problems in diabetes. One of the most important factors affecting the quality of diabetes care is knowledge and practice. The current study aimed at determining the knowl...

    Authors: Aydin Pourkazemi, Atefeh Ghanbari, Monireh Khojamli, Heydarali Balo, Hossein Hemmati, Zakiyeh Jafaryparvar and Behrang Motamed

    Citation: BMC Endocrine Disorders 2020 20:40

    Content type: Research article

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  35. Pituitary adenomas as multifactorial intracranial neoplasms impose a massive burden of morbidity on patients and characterizing the molecular mechanism underlying their pathogenesis has received considerable a...

    Authors: Nasrin Akbari, Mohammad Ghorbani, Vahid Salimi, Alimohammad Alimohammadi, Mohammad E. Khamseh, Hamideh Akbari, Mitra Nourbakhsh, Alireza Sheikhi, S. Fahimeh Taghavi and Masoumeh Tavakoli-Yaraki

    Citation: BMC Endocrine Disorders 2020 20:39

    Content type: Research article

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  36. The voltage-gated potassium channel Kv7.1 encoded by KCNQ1 is located in both cardiac myocytes and insulin producing beta cells. Loss-of-function mutations in KCNQ1 causes long QT syndrome along with glucose-stim...

    Authors: Jinyi Zhang, Christian R. Juhl, Louise Hylten-Cavallius, Morten Salling-Olsen, Allan Linneberg, Jens Juul Holst, Torben Hansen, Jørgen K. Kanters and Signe S. Torekov

    Citation: BMC Endocrine Disorders 2020 20:38

    Content type: Case report

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  37. Feel4Diabetes was a school and community based intervention aiming to promote healthy lifestyle and tackle obesity for the prevention of type 2 diabetes among families in 6 European countries. We conducted thi...

    Authors: Jemina Kivelä, Katja Wikström, Eeva Virtanen, Michael Georgoulis, Greet Cardon, Fernando Civeira, Violeta Iotova, Ernest Karuranga, Winne Ko, Stavros Liatis, Konstantinos Makrilakis, Yannis Manios, Rocío Mateo-Gallego, Anna Nanasi, Imre Rurik, Tsvetalina Tankova…

    Citation: BMC Endocrine Disorders 2020 20(Suppl 1):140

    Content type: Review

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    This article is part of a Supplement: Volume 20 Supplement 1

  38. Assessment of diet and physical activity and their determinants still remains a demanding task, especially when the objective is to evaluate the efficacy of lifestyle interventions. In the context of the Feel4...

    Authors: Costas A. Anastasiou, Evaggelia Fappa, Konstantina Zachari, Christina Mavrogianni, Vicky Van Stappen, Jemina Kivelä, Eeva Virtanen, Esther M. González-Gil, Paloma Flores-Barrantes, Anna Nánási, Csilla Semánová, Roumyana Dimova, Natalya Usheva, Violeta Iotova, Greet Cardon, Yannis Manios…

    Citation: BMC Endocrine Disorders 2020 20(Suppl 1):135

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 20 Supplement 1

  39. Type 2 diabetes mellitus (T2DM) comprises the vast majority of all diabetes cases in adults, with alarmingly increasing prevalence over the past few decades worldwide. A particularly heavy healthcare burden of...

    Authors: Ioannis Kyrou, Constantine Tsigos, Christina Mavrogianni, Greet Cardon, Vicky Van Stappen, Julie Latomme, Jemina Kivelä, Katja Wikström, Kaloyan Tsochev, Anna Nanasi, Csilla Semanova, Rocío Mateo-Gallego, Itziar Lamiquiz-Moneo, George Dafoulas, Patrick Timpel, Peter E. H. Schwarz…

    Citation: BMC Endocrine Disorders 2020 20(Suppl 1):134

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 20 Supplement 1

  40. Feel4Diabetes was a large-scale, multicenter lifestyle intervention aiming to prevent type 2 diabetes among families from vulnerable population groups in six European countries (Belgium, Bulgaria, Finland, Gre...

    Authors: Odysseas Androutsos, Costas Anastasiou, Christina-Paulina Lambrinou, Christina Mavrogianni, Greet Cardon, Vicky Van Stappen, Jemina Kivelä, Katja Wikström, Luis A. Moreno, Violeta Iotova, Kaloyan Tsochev, Nevena Chakarova, Tímea Ungvári, Zoltán Jancso, Konstantinos Makrilakis and Yannis Manios

    Citation: BMC Endocrine Disorders 2020 20(Suppl 1):27

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 20 Supplement 1

  41. The clinical and economic burden of type 2 diabetes mellitus on society is rising. Effective and efficient preventive measures may stop the increasing prevalence, given that type 2 diabetes mellitus is mainly ...

    Authors: Ruben Willems, Lore Pil, Christina-Paulina Lambrinou, Jemina Kivelä, Katja Wikström, Esther M. Gonzalez-Gil, Pilar De Miguel-Etayo, Anna Nánási, Csilla Semánová, Vicky Van Stappen, Greet Cardon, Kaloyan Tsochev, Violeta Iotova, Nevena Chakarova, Konstantinos Makrilakis, George Dafoulas…

    Citation: BMC Endocrine Disorders 2020 20(Suppl 1):14

    Content type: Methodology

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    This article is part of a Supplement: Volume 20 Supplement 1

  42. Feel4Diabetes (standing for: Families across Europe following a hEalthy Lifestyle for Diabetes prevention, http://​feel4diabetes-study.​eu/​) is a school and community based intervention program, aiming to prevent t...

    Authors: Stavros Liatis

    Citation: BMC Endocrine Disorders 2020 20(Suppl 1):13

    Content type: Commentary

    Published on:

    This article is part of a Supplement: Volume 20 Supplement 1

  43. The implementation of population screening and early prevention strategies targeting individuals at high-risk for type 2 diabetes (T2D) seems to be a public health priority. The current work aimed to describe ...

    Authors: Yannis Manios, Christina Mavrogianni, Christina-Paulina Lambrinou, Greet Cardon, Jaana Lindström, Violeta Iotova, Tsvetalina Tankova, Fernando Civeira, Jemina Kivelä, Zoltán Jancsó, Samyah Shadid, Kaloyan Tsochev, Rocío Mateo-Gallego, Sándorné Radó, George Dafoulas, Konstantinos Makrilakis…

    Citation: BMC Endocrine Disorders 2020 20(Suppl 1):12

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 20 Supplement 1

  44. Various guidelines recommend that all adults diagnosed with type 1 diabetes (T1D) should be offered an evidence based, structured education programme (SEP) to optimize self-management care. China has a 13,000 ...

    Authors: Yuting Xie, Fang Liu, Fansu Huang, Chunna Lan, Jia Guo, Jing He, Lezhi Li, Xia Li and Zhiguang Zhou

    Citation: BMC Endocrine Disorders 2020 20:37

    Content type: Research article

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  45. There is evidence of statin benefit among patients with diabetes regardless of cholesterol levels or prior cardiovascular disease history. Despite the evidence, there is under-prescription of statins in clinic...

    Authors: Julius Chacha Mwita, Brian Godman and Tonya M. Esterhuizen

    Citation: BMC Endocrine Disorders 2020 20:36

    Content type: Research article

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  46. Hypoglycemia in type 2 diabetes mellitus (T2DM) is still unsolved issue. The aim of this study was to investigate hypoglycemia in T2DM in participants treated with oral antihyperglycemic agents using different...

    Authors: Maja Baretić and Valeria Bralić Lang

    Citation: BMC Endocrine Disorders 2020 20:35

    Content type: Research article

    Published on: