Table 1 Demographic, clinical data and hormonal tests at the time of diagnosis of adrenocortical carcinoma
From: Coincidence of primary adrenocortical carcinoma and melanoma: three CASE reports
Characteristic | Case 1 | Case 2 | Case 3 |
|---|---|---|---|
Sex/Age (yrs) | M/37 | M/68 | M/50 |
Biochemistry at diagnosis | Â | Â | Â |
Sodium - mmol/L (nr) | 142 (133–146) | 137 (133–146) | 138 (133–146) |
Potassium - mmol/L (nr) | 4.2 (3.5–5.3) | 4.6 (3.5–5.3) | 5.0 (3.5–5.3) |
Creatinine - μmol/L (nr) | 91 (64–104) | 85 (64–104) | 76 (0–117) |
eGFR - mL/min (nr) | 82 (> 60) | 78 (> 60) | 107 (> 60) |
Endocrine workup at diagnosis | Â | Â | Â |
Aldosterone - pmol/L (nr) | 286 (< 750) | NA | NA |
Renin - mU/L (nr) | 35.1 (4.2–59.7 supine) | NA | NA |
Cortisol post 1 mg dexamethasone - mmol/L (nr) | < 28 (< 50) | NA | NA |
ACTH - ng/L (nr) | 27.5 (0–46) | NA | NA |
Androstenedione - nmol/L (nr) | 5.8 (1.1–5.6) | 1.6 (1.1–5.6) | NA |
Testosterone - nmol/L (nr) | 23.1 (7.0–27.0) | 18.9 (7.0–27.0) | NA |
DHEAS - μmol/L (nr) | 10.88 (3.80–13.10) | NA | NA |
17OHP - nmol/L (nr) | 2.5 (1.2–3.7) | 3.1 (1.2–3.7) | NA |
Plasma or urinary metanephrines | Normal | NA | NA |
Family history | Mother breast cancer Brother lung cancer | Negative | One brother melanoma One brother testis cancer |
Histology of melanoma | Â | Â | Â |
Initial staging | pT3b | metastatic | pT1a |
BRAF status | c.1799 T > A, p.V600E | c.1799 T > A, p.V600E | Unknown |
Histology of ACC | Â | Â | Â |
Initial staging | pT2 dedifferentiated | pT3 L1 V1 N0 blastematous | pT3 M1 |
ENSAT tumour stage | 2 | 3 | 4 |
Weiss score | 4 | unknown | 9 |
Ki67 index | 11% | 80% | 50% |