Table 1 Pretreatment and posttreatment values of clinical parameters of the patients for each treatment group

Age (years)

34.6 ± 6.1

31.6 ± 5.9

0.164

Weight (kg)

111.1 ± 14.8

104.7 ± 14.8

0.001

102.5 ± 9

98.9 ± 10.3

0.002

0.137

BMI (kg/m²)

39.2 ± 5.5

37.0 ± 5.5

0.001

37.5 ± 5.3

36.2 ± 5.5

0.002

0.482

Waist circumference (cm)

110.1 ± 12

105.9 ± 12.8

0.003

105.2 ± 10.7

103.0 ± 8.2

0.113

0.265

Androstenedione (nmol/l)

7.0 ± 3.7

7.7 ± 3.4

0.451

10.6 ± 6.4

8.6 ± 3.5

0.530

0.094

Total testosterone (nmol/l)

1.3 ± 0.7

1.2 ± 0.5

0.065

1.8 ± 0.9

1.5 ± 0.8

0.023

0.125

Free testosterone (pmol/l)

9.1 ± 5.1

9.7 ± 3.8

0.594

11.7 ± 5.7

11.0 ± 4.2

0.660

0.164

SHBG (nmol/l)

39.6 ± 41.4

46.9 ± 54.5

0.018

27.7 ± 21.1

47.2 ± 90.4

0.430

0.137

Glu 0 min OGTT (mmol/l)

5.2 ± 0.4

5.1 ± 0.4

0.341

5.4 ± 0.6

5.0 ± 0.3

0.015

0.635

Glu 120 min OGTT (mmol/l)

5.9 ± 1.0

4.7 ± 0.7

0.002

7.1 ± 2.0

5.9 ± 1.6

0.016

0.178

Insulin 0 min OGTT (mU/l)

22 ± 11.7

19.4 ± 10.4

0.272

24.5 ± 18.4

16.8 ± 13.2

0.035

0.839

Insulin 120 min OGTT (mU/l)

86.4 ± 40.3 [2]

68.9 ± 58.4

0.008

118.8 ± 87.5

109.1 ± 127.0

0.551

0.631

HOMA IR

5.1 ± 2.9

4.4 ± 2.4

0.272

5.9 ± 4.3

3.7 ± 3.0

0.013

0.910

Cholesterol (mmol/l)

4.8 ± 0.8

4.8 ± 0.8

0.875

4.9 ± 1.1 [1]

4.5 ± 1.0 [1]

0.107

0.720

HDL cholesterol (mmol/l)

1.3 ± 0.3

1.2 ± 0.3

0.194

1.3 ± 0.1 [1]

1.3 ± 0.2 [1]

0.627

0.239

LDL cholesterol (mmol/l)

2.9 ± 0.8

3.0 ± 0.7

0.928

3.0 ± 0.9 [1]

2.7 ± 0.9 [1]

0.049

0.905

TG (mmol/l)

1.5 ± 0.7

1.6 ± 0.6

0.727

1.4 ± 0.7 [1]

1.2 ± 0.5 [1]

0.075

0.550