- Case report
- Open Access
- Open Peer Review
Mazabraud’s syndrome and thyroid cancer, a very rare and confusing association: a case report
© Piciu et al. 2015
- Received: 22 February 2015
- Accepted: 24 July 2015
- Published: 6 August 2015
Mazabraud’s syndrome is defined as the association between fibrous dysplasia and intramuscular myxomas. The syndrome was first described in 1967 and, up until now, less than 100 cases have been reported worldwide. Here we report the association between this rare syndrome and thyroid cancer. When a malignant disease occurs in a patient affected by this syndrome, the differential diagnosis between benign and malignant bone lesions should be undertaken carefully.
We report the case of a 57-year-old Caucasian male, admitted for diffuse bone pain localized in the left leg and for the presence of an indolent, slow-growing mass in the left shoulder. The patient also presented with a thyroid nodule, highly suggestive of a malignancy. The radiologic examination showed multiple osteolytic lesions. The suspicion of multiple myeloma or bone metastases arising from a thyroid cancer was considered. Electrophoresis of proteins was negative and therefore excluded the diagnosis of multiple myeloma; the thyroid surgery was indicated. Thyroidectomy confirmed the papillary thyroid carcinoma, and the bone lesions were considered to be metastases from the thyroid cancer. After surgery, under thyroid-stimulated hormonal conditions, the patient underwent radioiodine therapy and a post-therapy radioiodine whole body scan. The lack of radioiodine uptake, both in the bone lesions and shoulder mass, suggested the possibility of less differentiated, non-avid radioiodine lesions, or the absence of any relation between pathologies. Considering the low level of the specific tumor marker, thyroglobulin, a bone biopsy and resection of the shoulder mass were indicated. The final diagnosis was intramuscular myxoma with polyostotic fibrous dysplasia in the deltoid muscle (Mazabraud’s syndrome). A completely incidental cerebral tumor lesion was also discovered.
During the evolution of a malignant disease, Mazabraud’s syndrome, known as the association of intramuscular myxoma with fibrous dysplasia, should be considered in the differential diagnosis of bone metastasis. This is the first report in the literature of Mazabraud’s syndrome occurring in a patient with thyroid cancer.
- Mazabraud’s syndrome
- Bone dysplasia
- Thyroid cancer
In 1967, the French physician Mazabraud described the association of intramuscular myxoma with fibrous dysplasia for the first time, naming the syndrome after himself [1, 2]. Fibrous dysplasia is a benign lesion in intramedullary bone. It can be found in two forms: a polyostotic (disseminated bone lesions) and a monostotic form (unique bone lesion) . Symptoms include localized tumoral and intermittent pain or even pathological fractures. The differential diagnosis includes neurofibromatosis, multiple myeloma, endochondromatosis, hyperparathyroidism and McCune–Albright syndrome . Intramuscular myxomas represent benign mesenchymal tumors associated with the polyostotic form of fibrous dysplasia in most women.
The incidence of Mazabraud’s syndrome is <1/1,000,000 [4–6], with only 68–80 cases reported in the medical literature worldwide [1, 2]. The official Orphanet report, published in July 2015 confirms the presence of 54 cases published in the literature (ORPHA number 57782) . The molecular diagnosis involves mutations in the GNAS1 gene, which encodes for an alpha subunit of a G protein .
Treatment of Mazabraud’s syndrome includes the specific treatment of the fibrous dysplasia when complications appear: pathological bone fractures treated using osteosynthesis, or when sarcoma transformation occurs, exceptionally, specific treatment for the malignant tumor. Intramuscular myxomas benefit from an excision and control of local and regional lesions.
We present the case of a 57-year-old Caucasian male with Mazabraud’s syndrome that was associated with a papillary thyroid carcinoma [8, 9]. A papillary thyroid cancer has been described in the literature, although in association with the McCune-Albright syndrome .
A 57-year-old male was referred to the Institute of Oncology Cluj-Napoca for a second opinion, with suspicion of a multiple myeloma. The patient presented with diffuse post-traumatic pain in the left thorax and the left tibial diaphysis. The clinical exam revealed a tumor lesion localized in the left deltoid region and another one in the anterior cervical region, suggestive of thyroid nodules. Right lateral cervical enlarged lymph nodes were also described. Conventional radiological examination highlighted areas of osteolysis in the right IVth costal arch and areas of osteolysis with ballooning in the left IVth, Vth and VIIth costal arches, as well as deformation and erosion of the cortical area of the bone.
The medical case presented is typical of Mazabraud’s syndrome, as described in the literature, however, the association with a malignant disease, seriously complicated the medical diagnosis and treatment.
Fibrous dysplasia has no predilection for the axial skeleton or the appendicular one. Statistics show that fibrous dysplasia has an incidence of 7 % of all benign bone lesions . In the case presented, the polyostotic form was predominant, with lesions being situated in the diaphysis-metaphysis region, pelvis and the costal arches, which occurs with a frequency of 15 % of all lesions. The trigger for this type of lesion is a genetic mutation in the GNAS1 gene situated on chromosome 20q that encodes the alpha subunit of a G protein, which plays an important role in cell proliferation . Fibrous dysplasia can also occur in the McCune–Albright syndrome, in which café-au-lait spots and endocrine disorders appear (nodular goiter, diabetes, early puberty and others) .
There are usually multiple intramuscular myxomas that occur in Mazabraud’s syndrome that appear before any bone lesion . The mean age at which Mazabraud’s syndrome is diagnosed is 47 years, and the disease is predominant in the female population . The most frequent pathologies associated with Mazabraud’s syndrome are benign thyroid diseases and early puberty. When a malignant tumor such as thyroid cancer is suspected, the presence of any other tumors in the brain, bones or soft tissues should be considered as potential metastases, unless other pathologies are ruled out. In this particular case, although a possible association between the two entities of myxoma and osseous dysplasia in Mazabraud’s syndrome is uncommon, it allowed the clinician to select the correct radical therapeutic strategy to treat the thyroid pathology.
The imaging techniques used for the diagnosis of Mazabraud’s syndrome involved conventional radiology to outline the bone lesions from the fibrous dysplasia using the “ground-glass” aspect and presenting areas of bone sclerosis . Bone scintigraphy was indicated to outline the polyostotic form and the implication of multiple bone structures. MRI was used to detect muscle tumor lesions and to find new lesions that were not clinically evident . Microscopy of the intramuscular myxoma was specific: hypocellularity, with a myxoid stroma, stellar aspect of the cells and the absence of nuclear atypia and of the necrosis .
There is no specific treatment for Mazabraud’s syndrome. A follow-up of the bone pathology was indicated in order to detect a possible malignant transformation. Intramuscular myxomas can be excised when they cause local pain . The association with a malignant disease is very challenging, especially if the genetic test is missing.
In the present clinical case, the specific uptake of radioiodine into only normal and tumoral thyroid cells during the WBS was the main reason for understanding the non-thyroid origin of the bone lesions. The chance of this case was the good prognostic of the malignant disease, which was considered for radical treatment. The limited information about Mazabraud’s syndrome and its low incidence might lead to the use of the wrong therapeutic strategy if other bone metastatic malignant diseases are involved.
Mazabraud’s syndrome continues to be a very rare disease, with <100 cases worldwide. Therefore, in assessing a bone lesion associated with a malignant disease, we should be warned about its features, considering that the confusing clinical presentation might result in inappropriate staging and therapy for a cancer patient.
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