Meyre D, Delplanque J, Chevre JC, Lecoeur C, Lobbens S, Gallina S, Durand E, Vatin V, Degraeve F, Proenca C: Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet. 2009, 41 (2): 157-159. 10.1038/ng.301.
Article
CAS
PubMed
Google Scholar
Garver WS, Heidenreich RA, Erickson RP, Thomas MA, Wilson JM: Localization of the murine Niemann-Pick C1 protein to two distinct intracellular compartments. J Lipid Res. 2000, 41 (5): 673-687.
CAS
PubMed
Google Scholar
Higgins ME, Davies JP, Chen FW, Ioannou YA: Niemann-Pick C1 is a late endosome-resident protein that transiently associates with lysosomes and the trans-Golgi network. Mol Genet Metab. 1999, 68 (1): 1-13. 10.1006/mgme.1999.2882.
Article
CAS
PubMed
Google Scholar
Neufeld EB, Wastney M, Patel S, Suresh S, Cooney AM, Dwyer NK, Roff CF, Ohno K, Morris JA, Carstea ED: The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo. J Biol Chem. 1999, 274 (14): 9627-9635. 10.1074/jbc.274.14.9627.
Article
CAS
PubMed
Google Scholar
Jelinek D, Heidenreich RA, Erickson RP, Garver WS: Decreased Npc1 gene dosage in mice is associated with weight gain. Obesity (Silver Spring). 2010, 18 (7): 1457-1459. 10.1038/oby.2009.415.
Article
CAS
Google Scholar
Jelinek D, Millward V, Birdi A, Trouard TP, Heidenreich RA, Garver WS: Npc1 haploinsufficiency promotes weight gain and metabolic features associated with insulin resistance. Hum Mol Genet. 2011, 20 (2): 312-321. 10.1093/hmg/ddq466.
Article
CAS
PubMed
Google Scholar
Kulyte A, Ryden M, Mejhert N, Dungner E, Sjolin E, Arner P, Dahlman I: MTCH2 in human white adipose tissue and obesity. J Clin Endocrinol Metab. 2011, 96 (10): E1661-1665. 10.1210/jc.2010-3050.
Article
CAS
PubMed
Google Scholar
Kolaczynski JW, Morales LM, Moore JH, Considine RV, Pietrzkowski Z, Noto PF, Colberg J, Caro JF: A new technique for biopsy of human abdominal fat under local anaesthesia with Lidocaine. Int J Obes Relat Metab Disord. 1994, 18 (3): 161-166.
CAS
PubMed
Google Scholar
Rodbell M: Localization of lipoprotein lipase in fat cells of rat adipose tissue. J Biol Chem. 1964, 239: 753-755.
CAS
PubMed
Google Scholar
Lofgren P, Hoffstedt J, Naslund E, Wiren M, Arner P: Prospective and controlled studies of the actions of insulin and catecholamine in fat cells of obese women following weight reduction. Diabetologia. 2005, 48 (11): 2334-2342. 10.1007/s00125-005-1961-6.
Article
CAS
PubMed
Google Scholar
Arner P, Stenson BM, Dungner E, Naslund E, Hoffstedt J, Ryden M, Dahlman I: Expression of six transmembrane protein of prostate 2 in human adipose tissue associates with adiposity and insulin resistance. J Clin Endocrinol Metab. 2008, 93 (6): 2249-2254. 10.1210/jc.2008-0206.
Article
CAS
PubMed
Google Scholar
van Harmelen V, Skurk T, Hauner H: Primary culture and differentiation of human adipocyte precursor cells. Methods Mol Med. 2005, 107: 125-135.
CAS
PubMed
Google Scholar
Jiao H, Arner P, Dickson SL, Vidal H, Mejhert N, Henegar C, Taube M, Hansson C, Hinney A, Galan P: Genetic association and gene expression analysis identify FGFR1 as a new susceptibility gene for human obesity. J Clin Endocrinol Metab. 2011, 96 (6): E962-966. 10.1210/jc.2010-2639.
Article
CAS
PubMed
Google Scholar
Laurencikiene J, Skurk T, Kulyte A, Heden P, Astrom G, Sjolin E, Ryden M, Hauner H, Arner P: Regulation of lipolysis in small and large fat cells of the same subject. J Clin Endocrinol Metab. 2011, 96 (12): E2045-2049. 10.1210/jc.2011-1702.
Article
CAS
PubMed
Google Scholar
Crocker AC, Farber S: Niemann-Pick disease: a review of eighteen patients. Medicine (Baltimore). 1958, 37 (1): 1-95. 10.1097/00005792-195802000-00001.
Article
CAS
Google Scholar
Jelinek DA, Maghsoodi B, Borbon IA, Hardwick RN, Cherrington NJ, Erickson RP: Genetic variation in the mouse model of Niemann Pick C1 affects female, as well as male, adiposity, and hepatic bile transporters but has indeterminate effects on caveolae. Gene. 2012, 491 (2): 128-134. 10.1016/j.gene.2011.10.010.
Article
CAS
PubMed
Google Scholar
Garver WS, Horwood JL, Erickson RP, Heidenreich RA, Jelinek D, Meaney FJ: The Niemann-Pick C1 gene interacts with a high-fat diet to promote weight gain in young mice. Obesity. 2010, 18: S54-S54. 10.1038/oby.2009.432.
Article
Google Scholar
Friedman JM, Halaas JL: Leptin and the regulation of body weight in mammals. Nature. 1998, 395 (6704): 763-770. 10.1038/27376.
Article
CAS
PubMed
Google Scholar