Non-alcoholic fatty liver disease and gestational diabetes mellitus: a bidirectional two-sample mendelian randomization study

Table 1 Details of the GWASs data included in the Mendelian randomization analyses

Phenotypes	Consortium	Ethnicity	Sample size	Number of SNPs	IEU GWAS ID	PMID
GDM	FinnGen	European	190,897	20,160,256	NA	NA
NAFLD1	UK Biobank	European	377,988	9,211,209	NA	34,535,985
NAFLD2	FinnGen	European	342,499	20,169,557	NA	NA
BMI	GIANT	European	681,275	2,336,260	ieu-b-40	30,124,842
WHR	GIANT	European	212,244	2,560,782	ieu-a-73	25,673,412
TG	UK Biobank	European	441,016	12,321,875	ieu-b-111	32,203,549
LDL-C	UK Biobank	European	440,546	12,321,875	ieu-b-110	32,203,549
HDL-C	UK Biobank	European	403,943	12,321,875	ieu-b-109	32,203,549
Apo A-1	UK Biobank	European	393,193	12,321,875	ieu-b-107	32,203,549
Apo B	UK Biobank	European	439,214	12,321,875	ieu-b-108	32,203,549
HOMA-B	MAGIC	European	36,466	2,454,220	ieu-b-117	20,081,858
HOMA-IR	MAGIC	European	37,037	2,455,342	ieu-b-118	20,081,858
TV	MRC-IEU	European	437,887	9,851,867	ukb-b-5192	NA
Computer	MRC-IEU	European	360,895	9,851,867	ukb-b-4522	NA
Driving	MRC-IEU	European	310,555	9,851,867	ukb-b-3793	NA

Abbreviations: GDM, gestational diabetes mellitus; NAFLD, nonalcoholic fatty liver disease; BMI, body mass index; WHR, waist-to-hip ratio; TG, triglycerides; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; Apo A-1, apolipoprotein A-I; Apo B, apolipoprotein B; HOMA-B, homeostasis model assessment of beta-cell function; HOMA-IR, homeostasis model assessment of insulin resistance; TV, Time spent watching television; Computer, Time spent using computer; Driving, Time spent driving; GIANT, Genetic Investigation of ANthropometric Traits; MAGIC, Meta-Analyses of Glucose and Insulin-related traits Consortium; MRC-IEU, Medical Research Council Intergrative Epidemiology Unit; SNPs, single-nucleotide polymorphisms; PMID, ID of publication in the PubMed; NA, not applicable

ISSN: 1472-6823