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Table 3 Quantitative histopathological analysis of pancreas, kidney, and liver tissues in the experimental groups

From: Effects of conditioned media derived from human Wharton’s jelly mesenchymal stem cells on diabetic nephropathy and hepatopathy via modulating TGF-β and apelin signaling pathways in male rats

Experimental Groups

Histopathological Variables

Control

DM

DM + hWJ-MSCs-CM

Pancreas tissue

Number of pancreatic islets

15.51 ± 1.82

5.23 ± 0.51***

9.93 ± 1.23** #

Mean diameter of islets (µm)

642.32 ± 74.50

258.62 ± 52.60****

566.23 ± 50.35##

Kidney tissue

Dilatation of the urinary space

0.00 ± 0.00

3.2 ± 0.03****

1.2 ± 0.04**** ##

Interstitial hemorrhage

0.00 ± 0.00

2.8 ± 0.07****

1.3 ± 0.01**** ##

Mononuclear infiltration

0.00 ± 0.00

3.1 ± 0.03****

1.8 ± 0.02**** ##

Liver tissue

Hepatic necrosis

0.00 ± 0.00

1.62 ± 0.04****

0.48 ± 0.03**** ####

Hepatic degeneration

0.00 ± 0.00

2.55 ± 0.05****

0.66 ± 0.02**** ####

Mononuclear cell inflammation

0.00 ± 0.00

1.51 ± 0.04****

0.55 ± 0.02**** ####

  1. Data are expressed as mean ± SEM
  2. **P < 0.01, ***P < 0.001, and ****P < 0.0001 represent significant differences with the Control group
  3. #P < 0.05, ##P < 0.01, and ####P < 0.0001 represent significant differences with the DM group. DM = Diabetic Mellitus; hWJ-MSCs-CM = Conditioned media derived from human Wharton’s jelly mesenchymal stem cells