Effects of conditioned media derived from human Wharton’s jelly mesenchymal stem cells on diabetic nephropathy and hepatopathy via modulating TGF-β and apelin signaling pathways in male rats

Table 2 State of diabetic indices and survival variables in the experimental groups

Experimental Groups Variables	Control	DM	DM + hWJ-MSCs-CM
FBG (mmol/L)	6.32 ± 0.71	32.2 ± 2.04^****	21.80 ± 1.89^{**** ##}
UAE (mg/24 h)	0.15 ± 0.01	65.74 ± 7.10^****	17.48 ± 0.70^{* ####}
ACR (mg/g)	0.41 ± 0.06	396.30 ± 45.06^****	50.14 ± 3.52^{**** ####}
Urine Output (ml/24 h)	7.53 ± 0.74	135.60 ± 13.13^****	61.50 ± 13.27^{** ###}
Water intake (mL/24 h)	23.13 ± 0.99	121.40 ± 4.14^****	63.13 ± 7.39^{**** ####}
Food intake (g/24 h)	14.50 ± 1.10	29.83 ± 2.02^****	22.08 ± 1.20^{** ##}
Body weight (g)	266.53 ± 3.30	167.90 ± 4.60^****	241.03 ± 6.91^{**** ####}

Data are expressed as mean ± SEM (n = 10)
^*P < 0.05, ^**P < 0.01 and ^****P < 0.0001 represent significant difference with Control group
^##P < 0.01, ^###P < 0.001 and ^####P < 0.001 represent significant difference with DM group
DM = Diabetic mellitus; hWJ-MSCs-CM = Conditioned media derived from human Wharton’s jelly mesenchymal stem cells;
FBG = Fasting blood glucose; UAE = Urine albumin excretion; ACR = urine albumin/creatinine ratio

ISSN: 1472-6823