Increased circulating FGF21 level predicts the burden of metabolic demands and risk of vascular diseases in adults with type 2 diabetes

Table 3 Partial correlation of serum FGF21 with other risk factors of CAS and HP

Variables	Serum FGF21^*		Serum FGF21^* (age-adjusted)		Serum FGF21^* (age-and T2DM duration-adjusted)
Variables	r	p	r	p	r	p
BMI	0.212	< 0.001	0.279	< 0.001	0.279	< 0.001
Male	0.108	0.004	0.059	0.304	0.059	0.304
Age	0.197	< 0.001	/	/	/	/
T2DM duration	0.072	0.058	-0.005	0.936	/	/
FPG^*	0.006	0.884	-0.013	0.818	-0.014	0.812
HbA1c^*	-0.058	0.124	-0.012	0.756	-0.012	0.757
SBP	0.196	< 0.001	0.085	0.406	0.085	0.411
DBP	0.098	0.01	0.108	0.294	0.110	0.285
TG^*	0.155	< 0.001	0.192	0.001	0.192	0.001
TC^*	-0.021	0.572	-0.015	0.792	-0.015	0.791
HDL-c^*	-0.069	0.070	-0.109	0.056	-0.109	0.056
LDL-c^*	-0.072	0.057	-0.064	0.262	-0.065	0.259
eGFR^*	-0.193	< 0.001	-0.095	0.097	-0.096	0.094
ALT^*	-0.039	0.666	0.051	0.376	0.060	0.295
ALP^*	0.042	0.266	0.028	0.625	0.028	0.623
Antihypertensive therapy	0.330	< 0.001	0.315	< 0.001	0.331	< 0.001
Left cIMT	0.226	< 0.001	0.212	< 0.001	0.212	< 0.001
Right cIMT	0.338	< 0.001	0.355	< 0.001	0.355	< 0.001
Plaque score	0.308	< 0.001	0.426	< 0.001	0.430	< 0.001

Note. ^* Log transformed before analysis. FGF21: fibroblast growth factor 21; BMI: body mass index; FPG: fasting plasma glucose; HbA1c: haemoglobin A1c; SBP: systolic blood pressure; DBP: diastolic blood pressure; TG: triglyceride; TC: total cholesterol; HDL-c: high-density lipoprotein cholesterol; LDL-c: low-density lipoprotein cholesterol; eGFR: estimated glomerular filtration rate; cIMT: carotid intima media thickness; ALT: alanine transaminase; AST: aspartate Transaminase; ALP: alkaline phosphatase; CAS: carotid atherosclerosis; HP: hypertension

ISSN: 1472-6823