Table 2 Comparison of variables between patients with and without high-risk LNM in the training cohort and internal test cohort

Sex

< 0.001

< 0.001

 female

3,733 (78%)

207 (62%)

1,588 (77%)

89 (60%)

 male

1,076 (22%)

125 (38%)

467 (23%)

59 (40%)

Age

< 0.001

< 0.001

 Mean (SD)

45 (10)

39 (10)

44 (10)

40 (9)

Tumor location

< 0.001

0.003

 upper

689 (14%)

17 (5.1%)

300 (15%)

13 (8.8%)

 middle

1,521 (32%)

96 (29%)

686 (33%)

37 (25%)

 lower

697 (14%)

45 (14%)

325 (16%)

23 (16%)

multifocal

1,902 (40%)

174 (52%)

744 (36%)

75 (51%)

Tumor size

< 0.001

< 0.001

 Mean (SD)

0.63 (0.20)

0.73 (0.20)

0.63 (0.21)

0.73 (0.19)

HT

0.006

0.003

 present

1,160 (24%)

58 (17%)

517 (25%)

21 (14%)

 absent

3,649 (76%)

274 (83%)

1,538 (75%)

127 (86%)

Microscopic capsular invasion

< 0.001

< 0.001

 absent

2,582 (54%)

136 (41%)

1,113 (54%)

58 (39%)

 present

2,227 (46%)

196 (59%)

942 (46%)

90 (61%)

Bilaterality

0.031

0.025

 absent

3,697 (77%)

238 (72%)

1,595 (78%)

103 (70%)

 present

1,112 (23%)

94 (28%)

460 (22%)

45 (30%)