Soluble receptor for advanced glycation end products (sRAGE) is associated with obesity rates: a systematic review and meta-analysis of cross-sectional study

Table 5 Subgroup analysis for the comparison of WC between the highest versus the lowest category of sRAGE

Group	No. of studies^*	WMD (95% CI)	P _{within group}	P _{between group *}	P _{heterogeneity}	I², %
Total	4	-5.602 -8.820 -2.383	0.001		0.002	79.5
Country				< 0.001
Japan	2	-3.109 -5.057 -1.161	0.002		0.221	33.3
Others	2	-8.572 -11.468 -5.676	< 0.001		0.287	11.8
Baseline WC (cm)				< 0.001
82 >	2	-4.860 -10.543 0.823	0.094		0.002	89.4
≥ 82	2	-7.139 -14.307 0.029	0.051		0.023	80.8
RAGE type				< 0.001
sRAGE	3	-7.005 -10.774 -3.237	< 0.001		0.016	75.7
esRAGE	1	-2.000 -4.441 0.441	0.108		-	-
Gender				< 0.001
Men	2	-3.109 -5.057 -1.161	0.002		0.221	33.3
Women	1	-11.40 -17.415 -5.385	< 0.001		-	-
Both	1	-7.800 -10.583 -5.017	< 0.001		-	-
Age group				< 0.001
< 80	3	-4.523 -7.578 -1.469	0.004		0.008	79.1
< 40	1	-11.40 -17.415 -5.385	< 0.001		-	-
*Sample size*	2
500 >	2	-6.282 -15.457 2.894	0.180	< 0.001	0.005	87.6
≥ 500	2	-5.782 -9.498 -2.065	0.002		0.032	78.3
*Study quality*				< 0.001
Moderate	1	-11.40 -17.415 -5.385	< 0.001		-	-
High	3	-4.523 -7.578 -1.469	0.004		0.008	79.1

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