Soluble receptor for advanced glycation end products (sRAGE) is associated with obesity rates: a systematic review and meta-analysis of cross-sectional study

Table 4 Subgroup analysis for the comparison of BMI between the highest versus the lowest category of sRAGE

Group	No. of studies^*	WMD (95% CI)	P _{within group}	P _{between group *}	P _{heterogeneity}	I², %
Total	6	-1.927 -2.868 -0.986	< 0.001	< 0.001	< 0.001	86.4
Country
Japan	4	-1.536 -1.893 -1.180	< 0.001		0.763	0
Others	2	-5.768 -15.957 4.420	0.267		< 0.001	97.2
*Baseline BMI (kg/m*²)				< 0.001
23 >	4	-1.536 -1.893 -1.180	< 0.001		0.763	0.0
≥ 23	2	-5.768 -15.957 4.420	0.267		< 0.001	97.2
RAGE type				< 0.001
sRAGE	4	-2.591 -4.225 -0.956	0.002		< 0.001	91.8
esRAGE	2	-1.498 -2.013 -0.983	< 0.001		0.703	0.0
Gender				< 0.001
Men	2	-1.614 -2.106 -1.123	< 0.001		0.426	0.0
Women	1	-11.100 -14.441 -7.759	< 0.001		-	-
Both	3	-1.219 -1.726 -0.712	< 0.001		0.257	26.5
Age group				< 0.001
< 80	3	-1.329 -1.946 -0.712	< 0.001		0.116	53.7
< 60	2	-1.450 -1.968 -0.931	< 0.001		0.571	0.0
< 40	1	-11.10 -14.441 -7.759	< 0.001		-	-
*Sample size*				< 0.001
300 >	3	-3.655 -6.095 -1.215	0.003		< 0.001	93.7
≥ 300	3	-1.329 -1.946 -0.712	< 0.001		0.116	53.7
*Study quality*				< 0.001
Moderate	3	-3.655 -6.095 -1.215	0.003		< 0.001	93.7
High	3	-1.329 -1.946 -0.712	< 0.001		0.116	53.7

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