Table 2 Characteristics of the studies included in the systematic review
Studies that reported the comparison of BMI between the highest versus the lowest sRAGE categories | |||||||||
|---|---|---|---|---|---|---|---|---|---|
First Author/ year | Country | Journal | Study Population | Gender/ male (%) | Age | BMI (kg/m2) | WC (cm) | Num. | Main finding |
Momma H/ 2014 [26] | Japan | Diabetol Metab Syndr | Healthy | Both / 80 | 30–83 | 22–25 | 82–86 | 712 | BMI was significantly lower in the highest versus the lowest category of sRAGE (22.7 versus 24.5 kg/m2; P < 0.001) |
Momma H/ 2014 [27] | Japan | J Clin Endocrinol Metab | Healthy | Men/ 100 | 30–83 | 21–24 | 81–84 | 426 | BMI was significantly lower in the highest versus the lowest category of esRAGE (21.9 versus 23.3 kg/m2; P < 0.001) |
Moriya S/ 2014 [28] | Japan | J Stroke Cerebrovasc Dis | Healthy | Both /58 | 40–60 | 22–24 | - | 142 | BMI in the highest category of sRAGE was significantly lower than the lowest (22.3 vs. 23.6 kg/m2; P < 0.001) Also, BMI in the highest category of esRAGE was significantly lower than the lowest (22.1 vs. 23.7 kg/m2; P < 0.001) |
Moy KA/ 2013 [30] | Finland | Hepatology | Healthy | Men/ 100 | 50–69 | 25–30 | - | 485 | BMI in the highest category of sRAGE was non-significantly lower than the lowest (26.4 vs. 27.1 kg/m2; P = 0.12) |
Zaki M/ 2017 [25] | Egypt | Excli J | Healthy | Women/ 0 | 18–35 | 25–35 | 75–100 | 100 | BMI in the highest category of sRAGE was significantly lower than the lowest (24.8 vs. 35.9 kg/m2; P < 0.05) |
Studies that reported the comparison of WC between highest versus lowest sRAGE categories | |||||||||
Chen L/ 2016 [42] | USA | Cancer Epidemiolo | Healthy | Women/ 0 | 50–79 | 18–40 | 75–90 | 638 | WC was significantly lower in the highest versus the lowest category of sRAGE (80.4 versus 86 cm; P < 0.001) |
Momma H/ 2014 [26] | Japan | Diabetol Metab Syndr | Healthy | Both / 80 | 30–83 | 22–25 | 82–86 | 712 | WC was significantly lower in the highest versus the lowest category of sRAGE (82 versus 86 cm; P < 0.001) |
Momma H/ 2014 [27] | Japan | J Clin Endocrinol Metab | Healthy | Men/ 100 | 30–83 | 21–24 | 81–84 | 426 | WC was significantly lower in the highest versus the lowest category of sRAGE (81 versus 83 cm; P < 0.001) |
Zaki M/ 2017 [25] | Egypt | Excli J | Healthy | Women/ 0 | 18–35 | 25–35 | 75–100 | 100 | WC was significantly lower in the highest versus the lowest category of sRAGE (80.7 versus 96.2 cm; P < 0.001) |
Studies that reported the comparison of sRAGE between individuals with and without obesity. | |||||||||
Amin MN/ 2011 [41] | Egypt | Int J Biomed Sci | Obese apparently healthy | Both /14 | 46–48 | 19–50 | - | 30 | Mean sRAGE in individuals with obesity was significantly lower compared with individuals without obesity (660.60 versus 504.42 pg/ml; P < 0.05) |
Amin MN/ 2011 [41] | Egypt | Int J Biomed Sci | Obese diabetic | Both /14 | 46–48 | 19–50 | - | 58 | Mean sRAGE in patients with diabetes and obesity was significantly lower compared with patients with diabetes but without obesity (294.68 versus 333.89 pg/ml; P < 0.05) |
Davis KE/ 2014 [31] | USA | Nutr Res | Obese apparently Healthy | Both /32 | 18–45 | 19–25 | - | 77 | Mean sRAGE in individuals with obesity was non significantly lower compared with individuals without obesity (404 versus 643 pg/ml; P = 0.07) |