The association between creatinine to body weight ratio and the risk of progression to diabetes from pre-diabetes: a 5-year cohort study in Chinese adults

Table 5 Relationship between Cre/BW ratio and diabetes in different sensitivity analyses

Exposure	Model I (HR,95%CI, P)	Model II (HR,95%CI, P)	Model III (HR,95%CI, P)	Model IV (HR,95%CI, P)
Cre/BW ratio	0.515 (0.399, 0.665) < 0.0001	0.475 (0.370, 0.612) < 0.0001	0.453 (0.359, 0.571) < 0.0001	0.446 (0.362, 0.549) < 0.0001
Cre/BW ratio (Deciles)
D1	Ref	Ref	Ref	Ref
D2	0.846 (0.679, 1.054) 0.13586	0.825 (0.688, 0.990) 0.03834	0.781 (0.659, 0.925) 0.00425	0.818 (0.703, 0.952) 0.00966
D3	0.753 (0.604, 0.937) 0.01116	0.787 (0.651, 0.952) 0.01346	0.767 (0.644, 0.913) 0.00289	0.743 (0.635, 0.868) 0.00018
D4	0.866 (0.699, 1.073) 0.18828	0.763 (0.630, 0.923) 0.00536	0.773 (0.649, 0.920) 0.00380	0.768 (0.656, 0.899) 0.00103
D5	0.714 (0.572, 0.890) 0.00279	0.677 (0.553, 0.830) 0.00017	0.665 (0.553, 0.799) < 0.0001	0.674 (0.571, 0.796) < 0.0001
D6	0.598 (0.479, 0.748) < 0.0001	0.730 (0.598, 0.891) 0.00198	0.620 (0.514, 0.748) < 0.0001	0.575 (0.485, 0.681) < 0.0001
D7	0.737 (0.590, 0.921) 0.00724	0.693 (0.559, 0.859) 0.00083	0.672 (0.553, 0.817) < 0.0001	0.667 (0.561, 0.792) < 0.0001
D8	0.646 (0.514, 0.813) 0.00019	0.646 (0.519, 0.805) 0.00010	0.613 (0.502, 0.749) < 0.0001	0.616 (0.516, 0.735) < 0.0001
D9	0.625 (0.495, 0.789) < 0.0001	0.584 (0.465, 0.734) < 0.0001	0.587 (0.479, 0.720) < 0.0001	0.584 (0.486, 0.702) < 0.0001
D10	0.567 (0.444, 0.725) < 0.0001	0.563 (0.443, 0.715) < 0.0001	0.524 (0.421, 0.652) < 0.0001	0.523 (0.430, 0.637) < 0.0001

Model I was sensitivity analysis in participants without BMI ≥ 28 kg/m² (N = 20,431). We adjusted age, gender, height, SBP, DBP, FPG, BUN, TG, HDL-c, LDL-c, ALT, AST, family history of diabetes, smoking and drinking status
Model II was a sensitivity analysis performed on never smoker participants (N = 17,784). We adjusted age, gender, height, SBP, DBP, FPG, BUN, TG, HDL-c, LDL-c, ALT, AST, family history of diabetes, and drinking status
Model III was a sensitivity analysis performed on never drinker participants (N = 19,704). We adjusted age, gender, height, SBP, DBP, FPG, BUN, TG, HDL-c, LDL-c, ALT, AST, family history of diabetes, and smoking status
Model IV was sensitivity analysis in participants without adjusting smoking and drinking status (N = 24,506). We adjusted age, gender, height, SBP, DBP, FPG, BUN, TG, HDL-c, LDL-c, ALT, AST, family history of diabetes
HR Hazard ratios, CI Confidence, Ref Reference, Cre/BW ratio Creatinine to body weight ratio

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