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Table 4 Meta-analysis of the association between the MCP-1 rs1024611polymorphism and DN risk (DN vs. T2DM)

From: Association between the MCP-1 -2518 A > G (rs1024611) polymorphism and susceptibility to type 2 diabetes mellitus and diabetic nephropathy: a meta-analysis

Genetic variant

Study group

No. of studies

Heterogeneity test

Association test (FE model)

Association test (RE model)

Publication bias

I2

P value

OR (95% CI)

P value

OR (95% CI)

P value

P value*

GG + GA vs.AA (dominant)

Overall

8

52.7

0.039

1.13 (0.93–1.37)

0.227

1.03 (0.74–1.42)

0.881

0.572

Population

        

Asian

7

59.4

0.022

1.12 (0.92–1.37)

0.254

1.00 (0.69–1.44)

0.996

 

Caucasian

1

-

-

1.21 (0.51–2.86)

0.662

1.21 (0.51–2.86)

0.662

 

Genotyping method

        

PCR–RFLP

6

0.0

0.458

0.83 (0.63–1.10)

0.197

0.84 (0.63–1.11)

0.220

 

ARMS-PCR

2

43.7

0.182

1.49 (1.14–1.95)

0.004

1.67 (0.96–2.90)

0.069

 

GG vs. GA + AA (recessive)a

Overall

6

73.9

0.002

1.08 (0.86–1.35)

0.532

1.07 (0.66–1.72)

0.786

0.875

Population

        

Asian

6

73.9

0.002

1.08 (0.86–1.35)

0.532

1.07 (0.66–1.72)

0.786

 

Genotyping method

        

PCR–RFLP

4

34.7

0.204

0.79 (0.60–1.04)

0.098

0.78 (0.54–1.11)

0.167

 

ARMS-PCR

2

0.0

0.728

2.10 (1.38–3.19)

 < 0.001

2.10 (1.38–3.19)

0.001

 

GG vs.AA (homozygote model)a

Overall

6

77.5

 < 0.001

1.24 (0.92–1.66)

0.161

1.06 (0.54–2.10)

0.867

0.646

Population

        

Asian

6

77.5

 < 0.001

1.24 (0.92–1.66)

0.161

1.06 (0.54–2.10)

0.867

 

Genotyping method

        

PCR–RFLP

4

42.8

0.155

0.70 (0.47–1.05)

0.087

0.67 (0.38–1.17)

0.158

 

ARMS-PCR

2

0.0

0.399

2.52 (1.59–3.97)

 < 0.001

2.51 (1.59–3.97)

 < 0.001

 

GG vs.GA (heterozygote model)a

Overall

6

56.1

0.044

1.06 (0.83–1.36)

0.631

1.05 (0.71–1.55)

0.802

0.975

Population

        

Asian

6

56.1

0.044

1.06 (0.83–1.36)

0.631

1.05 (0.71–1.55)

0.802

 

Genotyping method

        

PCR–RFLP

4

7.5

0.355

0.83 (0.62–1.12)

0.218

0.83 (0.60–1.13)

0.236

 

ARMS-PCR

2

0.0

0.963

1.80 (1.16–2.79)

0.009

1.80 (1.16–2.79)

0.009

 

G vs. A (allele contrast model)b

Overall

7

74.9

0.001

1.10 (0.96–1.26)

0.159

1.03 (0.76–1.40)

0.835

0.660

Population

        

Asian

6

79.1

 < 0.001

1.10 (0.96–1.26)

0.173

1.02 (0.73–1.42)

0.905

 

Caucasian

1

-

-

1.15 (0.55–2.40)

0.708

1.15 (0.55–2.40)

0.708

 

Genotyping method

        

PCR–RFLP

5

39.0

0.161

0.85 (0.70–1.02)

0.086

0.84 (0.65–1.08)

0.179

 

ARMS-PCR

2

51.4

0.152

1.46 (1.20–1.77)

 < 0.001

1.58 (1.08–2.32)

0.020

 
  1. Abbreviations: No. Number, RE Random-effects, FE Fixed-effects, PCR–RFLP Polymerase chain reaction-restriction fragment length polymorphism, ARMS-PCR Amplification refractory mutation detection system-polymerase chain reaction
  2. − Not available
  3. * Publication bias test (Egger’s test)
  4. a OR (95% CI) in two articles could not be calculated (Jeoh et al., 2013 and Karadeniz et al., 2010 [20])
  5. b OR (95% CI) in one article could not be calculated (Jeoh et al., 2013)
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BMC Endocrine Disorders

ISSN: 1472-6823

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