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Table 3 Meta-analysis of the association between the MCP-1 rs1024611polymorphism and DN risk (DN vs. healthy control)

From: Association between the MCP-1 -2518 A > G (rs1024611) polymorphism and susceptibility to type 2 diabetes mellitus and diabetic nephropathy: a meta-analysis

Genetic variant

Study group

No. studies

Heterogeneity test

Association test (FE model)

Association test (RE model)

Publication bias

I2

P value

OR (95% CI)

P value

OR (95% CI)

P value

P value*

GG + GA vs.AA (dominant)

Overall

7

33.5

0.172

1.27 (1.07–1.51)

0.007

1.25 (0.98–1.60)

0.072

0.770

Population

        

Asian

5

30.0

0.222

1.37 (1.11–1.71)

0.004

1.38 (1.01–1.88)

0.041

 

Caucasian

2

47.7

0.167

1.09 (0.82–1.47)

0.545

1.00 (0.60–1.67)

0.986

 

Genotyping method

        

PCR–RFLP

5

0.0

0.539

1.12 (0.88–1.42)

0.354

1.12 (0.88–1.42)

0.355

 

ARMS-PCR

2

72.8

0.055

1.48 (1.14–1.91)

0.003

1.87 (0.83–4.19)

0.128

 

GG vs. GA + AA (recessive)

Overall

7

60.6

0.019

1.17 (0.93–1.47)

0.178

1.19 (0.79–1.78)

0.400

0.934

Population

        

Asian

5

66.1

0.019

1.24 (0.96–1.59)

0.100

1.26 (0.80–2.00)

0.324

 

Caucasian

2

71.5

0.061

0.92 (0.54–1.56)

0.752

0.45 (0.79–1.78)

0.556

 

Genotyping method

        

PCR–RFLP

5

25.1

0.254

0.88 (0.66–1.18)

0.407

0.92 (0.65–1.32)

0.669

 

ARMS-PCR

2

19.4

0.265

1.92 (1.31–2.81)

0.001

1.96 (1.25–3.07)

0.003

 

GG vs.AA (homozygote model)

Overall

7

57.8

0.027

1.42 (1.09–1.86)

0.010

1.40 (0.88–2.23)

0.160

0.984

Population

        

Asian

5

58.8

0.046

1.61 (1.18–2.19)

0.003

1.55 (0.92–2.63)

0.099

 

Caucasian

2

73.9

0.050

0.97 (0.56–1.68)

0.907

0.45 (0.03–7.30)

0.576

 

Genotyping method

        

PCR–RFLP

5

19.3

0.291

1.02 (0.72–1.45)

0.918

1.07 (0.70–1.63)

0.763

 

ARMS-PCR

2

64.3

0.094

2.28 (1.50–3.47)

 < 0.001

2.70 (1.13–6.43)

0.025

 

GG vs.GA (heterozygote model)

Overall

7

44.8

0.093

1.06 (0.83–1.50)

0.652

1.08 (0.76–1.54)

0.676

0.821

Population

        

Asian

5

49.5

0.094

1.11 (0.85–1.45)

0.445

1.13 (0.75–1.68)

0.564

 

Caucasian

2

66.4

0.085

0.86 (0.49–1.50)

0.594

0.46 (0.04–5.16)

0.532

 

Genotyping method

        

PCR–RFLP

5

14.1

0.324

0.83 (0.61–1.13)

0.229

0.87 (0.61–1.22)

0.414

 

ARMS-PCR

2

0.0

0.563

1.62 (1.08–2.43)

0.019

1.62 (1.08–2.43)

0.019

 

G vs. A (allele contrast model)

Overall

7

67.2

0.006

1.17 (1.04–1.33)

0.010

1.13 (0.89–1.43)

0.304

0.892

Population

        

Asian

5

68.3

0.013

1.23 (1.07–1.42)

0.004

1.23 (0.92–1.64)

0.166

 

Caucasian

2

76.5

0.039

1.04 (0.83–1.33)

0.754

0.87 (0.46–1.67)

0.684

 

Genotyping method

        

PCR–RFLP

5

32.8

0.203

1.01 (0.86–1.19)

0.877

0.98 (0.80–1.21)

0.886

 

ARMS-PCR

2

80.2

0.025

1.43 (1.19–1.72)

 < 0.001

1.70 (0.94–3.05)

0.078

 
  1. Abbreviations: No. Number, RE Random-effects, FE Fixed-effects, PCR–RFLP Polymerase chain reaction-restriction fragment length polymorphism, ARMS-PCR Amplification refractory mutation detection system-polymerase chain reaction
  2. * Publication bias test (Egger’s test)
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