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Table 1 Clinical data of diabetic subjects with and without TNs

From: Association of systemic immune-inflammation index (SII) and aggregate index of systemic inflammation (AISI) with thyroid nodules in patients with type 2 diabetes mellitus: a retrospective study

Characteristics

Total

TNs

Non-TNs

z/t//χ2 values

P values

N = 370

 N = 229

 N = 141

  

Age(y)

62.0(21.0)

65.0(16.0)

52.0(23.0)

-6.353

< 0.001

Gender, male (%)

210(56.8)

105(45.9)

105(74.5)

29.117

< 0.001

Duration of diabetes(y)

10.0(15.0)

13.0(14.0)

7.0(14.0)

-3.887

< 0.001

DN, n (%)

167(45.1)

116(50.7%)

51(36.2%)

7.394

0.007

SII

400.0(297.3)

443.2(338.3)

335.1(234.4)

-4.677

< 0.001

AISI

151.1(141.9)

173.2(180.7)

134.9(86.7)

-4.314

< 0.001

TT3(ng/ml)

0.8(0.3)

0.8(0.2)

0.9(0.3)

-2.297

0.017

FT3 (pg/mL)

3.0(1.5)

3.0(0.6)

3.1(0.6)

-2.720

0.007

TSH (µIU/ml)

1.8(1.4)

1.8(1.5)

1.8(0.9)

-0.766

0.444

TT4 (µg/dL)

8.9 ± 1.7

9.0 ± 1.7

8.6 ± 1.7

2.253

0.025

FT4 (ng/dL)

0.9(0.2)

0.9(0.2)

0.9(0.2)

-0.809

0.419

TPOAB (IU/ml)

0.5(0.8)

0.5(0.9)

0.5(0.8)

-0.731

0.465

TGAB (IU/ml)

0.0(0.1)

0.0(0.2)

0.0(0.1)

-0.415

0.678

Scr (µmol/L)

66.0(29.0)

65.0(31.0)

66.0(26.0)

-0.090

0.928

eGFR(ml/min)

94.4(27.6)

91.3(30.8)

104.5(25.2)

-4.909

< 0.001

BUN (mmol/L)

5.4(2.6)

5.6(3.0)

5.1(2.7)

-2.194

0.028

UA (µmol/L)

321.5(149.0)

325.0(154.0)

312.0(130.0)

-1.360

0.174

FPG (mmol/L)

8.0(4.2)

8.2(4.5)

7.7(3.8)

-1.564

0.118

HbA1c (%)

8.9(3.2)

8.7(3.3)

9.3(3.1)

-1.568

0.117

HOMA-IR

4.0(4.5)

4.2(5.0)

3.6(3.8)

-1.768

0.077

INS (mIU/L)

11.4(10.3)

11.6(10.8)

10.7(10.1)

-1.286

0.198

 C-P(ng/ml)

2.0(1.7)

2.0(1.7)

2.0(1.8)

-0.259

0.795

TG (mmol/L)

1.6(1.2)

1.7(1.3)

1.6(1.0)

-0.996

0.319

CHO (mmol/L)

4.3(1.5)

4.4(1.5)

4.3(1.5)

-0.882

0.378

HDL (mmol/L)

1.0(0.4)

1.0(0.4)

0.9(0.3)

-1.551

0.121

LDL (mmol/L)

2.6 ± 0.9

2.6 ± 0.9

2.6 ± 0.9

-0.039

0.969

  1. Note: Continuous variables were reported as mean ± standard deviation (SD) for normalized distribution or median with interquartile range (IQR) for non-normal variables, and categorical variables were reported as n (%)
  2. Abbreviations: SII, systemic immune-inflammation index; AISI, aggregate index of systemic inflammation; TT3, total Triiodothyronine; FT3, free triiodothyronine; TSH, thyroid stimulating hormone; TT4, total thyroxine; FT4, free thyroxine; TPOAB, Thyroid peroxidase antibody; TGAB, thyroglobulin antibody; Scr, serum creatinine; eGFR, estimated glomerular filtration rate; BUN, blood urea nitrogen; UA, uric acid; FPG, fasting plasma glucose; HbA1c (%), glycated hemoglobin type A1c; INS, insulin; C-P, C-peptide; TG, triglycerides; CHO, total cholesterol; HDL, high-density lipoprotein cholesterol; LDL, low-density lipoprotein cholesterol; HOMA-IR, (fasting insulin × fasting glucose)/405 with glucose measured in mg/dL and insulin in µU/L.