Fig. 1

The mechanism of the effect of DPI on hypertension, polyphenols with anti-inflammatory and antioxidant properties are directly effective in reducing blood pressure [52], meanwhile, polyphenols have vasodilation effects by producing NO and converting GTP to c-GMP [53], as well as producing EDHF and hyperpolarization, followed by relaxation of vascular smooth muscles [46]. DPI, dietary polyphenol intake; NO, nitric oxide; EDHF, endothelium-derived hyperpolarizing factor; GTP, guanosine triphosphate; cGMP, cyclic guanosine monophosphate