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Table 4 Associations between early pregnancy serum uric acid levels and gestational diabetes & adverse infant birth outcomes stratified by BMI

From: Associations of early pregnancy serum uric acid levels with risk of gestational diabetes and birth outcomes: a retrospective cohort study

 

BMI < 24 kg/m2 (N = 4,727)

 

24 ≤ BMI < 28 kg/m2 (N = 9,302)

 

BMI ≥ 28 kg/m2 (N = 4,221)

Crude P-interaction

P-interaction

 

OR

95%CI

P

 

OR

95%CI

P

 

OR

95%CI

P

Hyperuricemia versus normal (reference)

           

Gestational diabetes mellitus

1.149

(0.823, 1.604)

0.415

 

1.517

(1.238, 1.859)

< 0.001

 

1.351

(1.057, 1.725)

0.016

0.294

0.467

Caesarean section

1.039

(0.866, 1.246)

0.681

 

1.057

(0.938, 1.190)

0.365

 

1.057

(0.907, 1.232)

0.475

0.224

0.700

Premature birth

1.269

(0.928, 1.736)

0.136

 

1.221

(0.939, 1.589)

0.136

 

1.806

(1.296, 2.515)

< 0.001

0.081

0.064

Low birth weight

0.931

(0.674, 1.285)

0.663

 

1.419

(1.069, 1.885)

0.016

 

1.196

(0.769, 1.859)

0.426

0.115

0.076

Macrosomia

1.143

(0.440, 2.967)

0.784

 

0.847

(0.553, 1.297)

0.445

 

0.822

(0.583, 1.159)

0.264

0.738

0.523

Small for gestational age

0.930

(0.730, 1.184)

0.556

 

1.177

(0.962, 1.440)

0.113

 

1.383

(1.008, 1.896)

0.045

0.074

0.028

Large for gestational age

1.016

(0.766, 1.347)

0.911

 

1.070

(0.899, 1.272)

0.446

 

1.148

(0.957, 1.378)

0.138

0.169

0.355

Per one SD increase in uric acid concentration

          

Gestational diabetes mellitus

1.177

(1.041, 1.332)

0.009

 

1.213

(1.114, 1.320)

< 0.001

 

1.199

(1.075, 1.337)

0.001

0.619

0.679

Caesarean section

1.022

(0.955, 1.093)

0.530

 

1.001

(0.956, 1.048)

0.972

 

1.044

(0.978, 1.115)

0.196

0.117

0.342

Premature birth

1.002

(0.885, 1.133)

0.978

 

1.146

(1.032, 1.273)

0.011

 

1.330

(1.140, 1.552)

< 0.001

0.002

0.001

Low birth weight

1.027

(0.915, 1.154)

0.646

 

1.191

(1.059,1.339 )

0.003

 

1.247

(1.031, 1.509)

0.023

0.019

0.008

Macrosomia

0.934

(0.644, 1.357)

0.721

 

0.938

(0.799, 1.100)

0.430

 

0.909

(0.787, 1.049)

0.193

0.276

0.609

Small for gestational age

1.022

(0.936, 1.116)

0.629

 

1.107

(1.022, 1.199)

0.013

 

1.126

(0.977, 1.298)

0.100

0.247

0.110

Large for gestational age

0.954

(0.859, 1.060)

0.384

 

0.960

(0.896, 1.028)

0.245

 

1.001

(0.924, 1.085)

0.980

0.139

0.322

  1. The associations were adjusted for maternal age, BMI, parity, and gestational weeks of uric acid measurement
  2. Crude P-interaction: P-interaction calculated without adjustment of other covariates
  3. P-interaction: P-interaction calculated with full adjustment of covariates
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BMC Endocrine Disorders

ISSN: 1472-6823

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