Associations of early pregnancy serum uric acid levels with risk of gestational diabetes and birth outcomes: a retrospective cohort study

Table 3 Associations between early pregnancy serum uric acid levels and gestational diabetes & adverse infant birth outcomes stratified by gestational weeks of measurement

	< 17 weeks (N = 6,613)			≥ 17 weeks (N = 11,637)			Crude P-interaction	P-interaction
	OR	95%CI	P	OR	95%CI	P	Crude P-interaction	P-interaction
Hyperuricemia versus normal (reference)
Gestational diabetes mellitus	1.365	(1.100, 1.695)	0.005	1.417	(1.175, 1.707)	< 0.001	0.756	0.834
Premature birth	1.338	(1.012, 1.768)	0.041	1.414	(1.140, 1.754)	0.002	0.709	0.777
Low birth weight	1.122	(0.821, 1.534)	0.471	1.238	(0.973, 1.577)	0.083	0.403	0.630
Macrosomia	0.981	(0.655, 1.469)	0.925	0.760	(0.542, 1.066)	0.112	0.758	0.472
Small for gestational age	1.151	(0.911, 1.455)	0.239	1.112	(0.936, 1.321)	0.226	0.919	0.970
Large for gestational age	1.025	(0.849, 1.239)	0.795	1.143	(0.990, 1.319)	0.068	0.486	0.395
Per one SD increase in uric acid concentration
Gestational diabetes mellitus	1.235	(1.129, 1.351)	< 0.001	1.183	(1.094, 1.278)	< 0.001	0.676	0.419
Premature birth	1.166	(1.039, 1.308)	0.009	1.120	(1.024, 1.225)	0.013	0.677	0.550
Low birth weight	1.197	(1.060, 1.352)	0.004	1.095	(0.995, 1.206)	0.063	0.364	0.241
Macrosomia	0.982	(0.830, 1.162)	0.835	0.884	(0.777, 1.007)	0.063	0.398	0.512
Small for gestational age	1.098	(0.999, 1.206)	0.052	1.068	(0.999, 1.142)	0.053	0.828	0.786
Large for gestational age	0.928	(0.858, 1.003)	0.060	1.004	(0.948, 1.065)	0.884	0.184	0.150

The mean (sd) gestational weeks were 14.7 (1.89), and 18.3 (0.83) for the < 17 weeks, and the ≥ 17 weeks groups, respectively
The associations were adjusted for maternal age, BMI, parity, and gestational weeks of uric acid measurement
Crude P-interaction: P-interaction calculated without adjustment of other covariates
P-interaction: P-interaction calculated with full adjustment of covariates

ISSN: 1472-6823