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Table 2 Effect on anthropometrics and HOMA-IR

From: Effects of GLP1RAs on pregnancy rate and menstrual cyclicity in women with polycystic ovary syndrome: a meta-analysis and systematic review

Study Group

No. of Studies/Subgroups

Heterogeneity

Effects Estimate (95% CI)

P value

BMI (WMD)

9

P = 0.147, I2 = 31.5%

-1.21 (-1.74, -0.68)

P < 0.001

 GLP1RA + MET vs MET

3

P = 0.825, I2 = 0%

-0.71 (-2.15, 0.73)

P = 0.335

 GLP1RA vs MET

7

P = 0.218, I2 = 27.6%

-1.05 (-1.69, -0.42)

P = 0.001

 GLP1RA vs Placebo

1

Not Applicable

-2.00 (-2.79, -1.21)

P < 0.001

WC (WMD)

9

P = 0.470, I2 = 0%

-2.90 (-3.65, -2.16)

P < 0.001

TBF (WMD)

5

P = 0.003, I2 = 72.5%

-1.44 (-2.93, 0.05)

P = 0.058

 European

5

P = 0.772, I2 = 0%

-1.84 (-4.60, 0.92)

P < 0.001

 Chinese

1

Not Applicable

-1.30 (-1.73, -0.87)

P < 0.001

HOMA-IR (WMD)

10

P = 0.573, I2 = 0%

-0.65 (-0.80, -0.51)

P < 0.001