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Table 5 Final diagnosis, lateralization, MRI results, and management

From: Bilateral inferior petrosal sinus sampling: validity, diagnostic accuracy in lateralization of pituitary microadenoma, and treatment in eleven patients with Cushing’s syndrome – a single-center retrospective cohort study

Case number

Diagnosis

MRI

Lateralization according to MRI

Lateralization according to inter-sinus ratio

Lateralization at the time of surgery

IHC

Management

1

CD

3 mm Rt. adenoma

Rt.

Rt.

Rt.

ACTH + pituitary adenoma

TSS

2

CD

5.5 mm Rt. and 2.5 mm Lt. adenoma

Bilateral

Lt.

Bilateral

ACTH + pituitary adenoma

TSS

3

CD

3.8 mm Rt. adenoma

Rt.

Rt.

Rt.

ACTH + pituitary adenoma

TSS

4

CD

Lt. side enhancement

Lt.

Rt.

Rt.

corticotroph adenoma

TSS

5

CD

6 mm Rt. adenoma and 4.5 mm LLL nodule

Bilateral

Rt.

Rt.

ACTH + pituitary adenoma

TSS

6

CD

4 mm Lt. adenoma and 4 mm RUL nodule

Bilateral

Lt.

Lt.

ACTH + pituitary adenoma

TSS

7

recurrent CD

13 mm Rt. low signal pituitary Mass

Rt.

Rt

Rt.

ACTH + pituitary adenoma

TSS

8

recurrent CD

partially empty sella

Equivocal

Lt.

 

ACTH -

Pituitary Mass

TSS

9

EAS

empty sella

Equivocal

Equivocal

  

Medical treatment

10

EAS

1.9 mm Rt. pituitary Lesion & LLL mass

Bilateral

Equivocal

 

ACTH + carcinoid tumor of the lung

Lung lobectomy

11

EAS

possible pituitary adenoma and adrenal mass

Equivocal

Equivocal

 

Pheochromocytoma

bilateral adrenalectomy

  1. IHC: immunohistochemistry; CD: Cushing’s disease; EAS: ectopic ACTH syndrome; Rt: right; Lt: left; ACTH: adrenocorticotropic hormone; TSS: transsphenoidal surgery; LLL: left lower lobe; RUL: right upper lobe