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Table 3 ANOVA table across genotypes for stable cohort

From: SNP rs11185644 in RXRA gene and SNP rs2235544 in DIO1 gene predict dosage requirements in a cross-sectional sample of hypothyroid patients

Polymorphism

Genotype

N

Conc T4/dose

(mean)

P value, q value

Weekly dose

P value, q value

Daily dose

P value, q value

Weekly dose/kg

P value, q value

Daily dose/kg

P value, q value

TSH

P value, q value

T4

pmol/l

P value, q value

T3

pmol/l

P value, q value

BMI

P value, q value

rs11249460

AA

9

2.04

0.766

0.891

712.5

0.363

0.253

101.79

0.363

0.253

8.62

0.556

0.412

1.23

0.556

0.412

2.44

0.045#

0.757

19.62

0.642

0.757

4.28

0.585

0.834

33.87

0.02#

0.795

 

AG

39

1.65

614.1

87.73

8.50

1.21

1.73

18.74

4.34

28.09

 

GG

27

1.58

542.4

77.49

7.45

1.06

1.52

19.34

4.47

28.05

rs2235544

AA

14

2.03

0.408

0.800

516.07

0.485

0.873

73.72

0.485

0.873

7.11

0.191

0.757

1.02

0.191

0.757

1.87

0.780

0.938

18.91

0.972

0.978

4.36

0.002#

0.108*

28.64

0.012#

0.243

 

AC

30

1.51

642.50

91.79

9.20

1.31

1.65

19.16

4.15

26.47

 

CC

32

1.66

595.31

85.04

7.63

1.09

1.76

19.05

4.64

30.92

rs225014

CC

10

1.26

0.074

0.500

652.50

0.536

0.891

93.21

0.536

0.891

9.02

0.406

0.800

1.29

0.406

0.800

1.58

0.678

0.938

19.25

0.938

0.970

4.25

0.713

0.938

30.10

0.725

0.938

 

CT

32

1.99

551.17

78.74

7.40

1.06

1.85

19.16

4.39

28.35

 

TT

34

1.51

629.04

89.86

8.55

1.22

1.68

18.92

4.42

28.76

rs225015

AA

8

1.30

0.415

0.800

618.75

0.799

0.938

88.39

0.799

0.938

8.91

0.594

0.891

1.27

0.594

0.891

1.85

0.946

0.970

19.26

0.978

0.978

4.30

0.863

0.970

29.51

0.925

0.970

 

AG

32

1.87

569.92

81.42

7.58

1.08

1.73

19.00

4.37

28.80

 

GG

36

1.59

621.18

88.74

8.45

1.21

1.72

19.08

4.41

28.59

rs3806596

CC

32

1.65

0.407

0.800

624.22

0.295

0.771

89.17

0.295

0.771

8.24

0.270

0.757

1.18

0.270

0.757

1.69

0.186

0.757

19.65

0.018#

0.253

4.24

0.086

0.536

29.96

0.271

0.757

 

CT

34

1.83

542.65

77.52

7.51

1.07

1.63

19.27

4.54

28.20

 

TT

10

1.25

712.50

101.79

9.90

1.41

2.26

16.49

4.29

26.85

rs3064744

*1/*28

43

1.81

0.261

0.757

602.03

0.935

0.970

86.00

0.935

0.970

7.76

0.360

0.795

1.11

0.360

0.795

1.69

0.652

0.938

20.00

0.003#

0.108*

4.31

0.218

0.757

30.42

0.004#

0.108*

 

*1/*36

33

1.49

595.83

85.12

8.64

1.23

1.79

17.85

4.47

26.56

rs11185644

CC

7

1.79

0.557

0.891

521.43

0.025#

0.253

74.49

0.025#

0.253

7.62

0.056#

0.412

1.09

0.056#

0.412

1.43

0.166

0.757

20.35

0.237

0.757

4.60

0.443

0.834

26.71

0.335

0.795

 

CT

28

1.48

729.91

104.27

9.59

1.37

2.01

19.52

4.31

29.95

 

TT

41

1.79

523.48

74.78

7.21

1.03

1.60

18.53

4.40

28.31

rs4588

GG

40

1.75

0.861

0.970

540.00

0.208

0.757

77.14

0.208

0.757

7.27

0.131

0.707

1.04

0.131

0.707

1.83

0.703

0.938

19.04

0.878

0.970

4.42

0.697

0.938

29.04

0.839

0.970

 

GT

33

1.60

674.24

96.32

9.21

1.32

1.63

19.17

4.36

28.35

 

TT

3

1.57

566.67

80.95

7.58

1.08

1.65

18.19

4.16

29.91

rs602662

AA

27

1.75

0.578

0.891

537.04

0.267

0.757

76.72

0.267

0.757

7.66

0.342

0.795

1.09

0.342

0.795

1.74

0.711

0.938

18.85

0.897

0.970

4.32

0.778

0.938

28.06

0.749

0.938

 

AG

40

1.72

610.62

87.23

8.04

1.15

1.68

19.15

4.41

29.19

 

GG

9

1.28

736.11

105.16

9.96

1.42

1.98

19.35

4.45

29.00

  1. # significant p value at the level of < 0.05, * significant after correction for multiple testing, FDR of 0.2
  2. Doses are in mcg or mcg/kg. Normality of data was checked visually. Levene’s test was used to check for equal variance before running ANOVA. Welch’s test was used when equality of variance was not met. Post hoc analysis results of Tukey HSD: SULT1B1 rs11249460 AA Vs. GG only (P = 0.035) for TSH and both AA Vs. GG and AA Vs. AG (P = 0.026, 0.02 respectively) for BMI. DIO1 rs2235544: AC Vs. CC only for both BMI (P = 0.008) and T3 (P = 0.001). UGT1A4 Rs3806596: TT Vs. CC (P = 0.014) and TT Vs. CT (P = 0.035) for T4. VD rs11185644: CT Vs. TT (P = 0.023) for both weekly dose and daily dose
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BMC Endocrine Disorders

ISSN: 1472-6823

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