Fig. 1
Associations of obesity and body shape indices with erythrocyte and reticulocyte parameters. ABSI – a body shape index; BMI – body mass index; CI – confidence interval; HI – hip index; IRF– immature reticulocyte fraction; MCH – mean corpuscular haemoglobin; MCHC – mean corpuscular haemoglobin concentration; MCV – mean corpuscular volume; MRV – mean reticulocyte volume; RDW – red cell distribution width; SD – standard deviation (SDW – women; SDM – men). SDchange (95% CI) – regression coefficient (95% confidence interval) interpreted as the change in haematological parameters on SD scale per one SD increase of each anthropometric index. Estimates were obtained from multivariable linear regression models, including each erythrocyte or reticulocyte parameter as an outcome variable (sex-specific z-scores, value minus mean divided by SD). Exposure variables included BMI, ABSI, and HI (sex-specific z-scores). Adjustment variables included height, age, recent weight change, smoking status, alcohol consumption, physical activity, Townsend deprivation index, dietary intake (fruit, vegetables, red meat, processed meat, poultry, fish, cheese, bread, cereals, tea, coffee), recent major dietary change, region of the assessment centre, time of blood collection, fasting time, use of nonsteroidal anti-inflammatory drugs, use of vitamins ACE, vitamin D and minerals, or multivitamins, and for women, menopausal status, hormonal replacement therapy use, oral contraceptives use, and age at the last live birth. Values are shown in Supplementary Table S3. A – p-value for the interaction term between BMI and sex, from a joint model including women (reference) and men, with adjustment for ABSI, HI, and all covariates, except female-specific, but including an interaction term between age and sex, to account for potential differences by menopausal status in women. B – p-value for the interaction term between ABSI and sex or HI and sex, from a joint model including women (reference) and men, with adjustment for BMI and all covariates, except female-specific, but including an interaction term between age and sex. * p < 0.001; ** p < 1*10–6