Fig. 4
From: PIWIL2 restrains the progression of thyroid cancer via interaction with miR-146a-3p
Over-expression of miR-146a-3p promoted the proliferation of TC cell lines by down-regulating PIWIL2.
(A) The cell viability of TPC-1 cells after miR-146a-3p was over-expressed or knocked down. (B) The cell viability of TPC-1 cells after PIWIL2 was over-expressed or knocked down. (C) The cell viability of KTC-3 cells after miR-146a-3p was over-expressed or knocked down. (D) The cell viability of KTC-3 cells after PIWIL2 was over-expressed or knocked down. (E, F) The mRNA level of p53 and c-Myc in TPC-1 and KTC-3 cells. (G) The protein levels of P21, CyclinD1, PD-1 and CyclinE was measured by Western blot. ##: P < 0.01 between groups. N = 6. TC: thyroid cancer