Impact of glycemic control on the progression of aortic stenosis: a single-center cohort study using a common data model

Table 3 Multivariable logistic regression models for the predictors of accelerated AS progression

	Assessed as continuous variables			Assessed as categorical variables
	Adjusted OR	95% CI	P value	Adjusted OR	95% CI	P value
Male sex	1.539	1.092 – 2.177	0.014	-	-	-
Total cholesterol (per + 1 mg/dL)	1.007	1.002 – 1.011	0.002	1.006	1.002 – 1.010	0.005
Mean HbA1 during follow-up (per + 1%-unit increase in HbA1c)	1.267	1.106 – 1.453	< 0.001	-	-	-
HbA1c ≥ 7.0%	-	-	-	1.524	1.010 – 2.285	0.043
Vpeak (per + 1 m/sec)	1.659	1.233 – 2.231	< 0.001	-	-	-
Vpeak ≥ 3 m/sec	-	-	-	1.696	1.151 – 2.487	0.007
Use of RAS blocker	0.657	0.454 – 0.943	0.024	0.654	0.453 – 0.935	0.021
Use of spironolactone	-	-	-	0.293	0.068 – 0.865	0.050

Univariable factors with P-values < 0.1 were entered into the multivariable logistic regression analysis, using the stepwise backward elimination with the AIC method. Variables with significant association with accelerated AS progression (△Vpeak/year > 0.2 m/sec/year) are shown
Abbreviations: OR odds ratio, CI, confidence interval, HbA1c glycated hemoglobin, Vpeak aortic valve maximal velocity, RAS renin-angiotensin system

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