The nonlinear correlation between alanine aminotransferase to high-density lipoprotein cholesterol ratio and the risk of diabetes: a historical Japanese cohort study

Table 6 Effect size of ALT/HDL-C ratio on diabetes in prespecified and exploratory subgroups

Independent variables	No of patients	Effect size(95%CI)	P value	P for interaction
Age(years)				0.015
< 60	14,631	1.01 (1.00, 1.02)	0.300
≥ 60	711	1.05 (1.02, 1.09)	0.003
Gender				0.158
Female	7028	1.03 (1.00, 1.05)	0.021
Male	8314	1.01 (1.00, 1.02)	0.069
Ethanol consumptio (g/week)				0.109
< 40	10,685	1.00 (0.99, 1.02)	0.599
≥ 40, < 140	2769	1.03 (1.01, 1.05)	0.009
≥ 140, < 280	1352	1.04 (1.00, 1.07)	0.062
≥ 280	536	1.03 (0.99, 1.07)	0.176
Smoking status				0.336
Never-smoker	8988	1.00 (0.98, 1.02)	0.791
Ex-smoker	2914	1.02 (1.00, 1.04)	0.042
Current-smoker	3440	1.02 (1.00, 1.03)	0.0370
Habit of exercise				0.055
No	12,641	1.01 (1.00, 1.02)	0.008
Yes	2701	0.98 (0.95, 1.01)	0.2700
Hypertension				0.040
No	14,399	1.01 (0.99, 1.02)	0.357
Yes	943	1.04 (1.01, 1.06)	0.009
BMI (kg/m²)				0.486
< 25	12,905	1.02 (1.00, 1.03)	0.023
≥ 25	2437	1.01 (0.99, 1.02)	0.233

Note 1: Above model adjusted for we adjusted for gender, age, ethanol consumption, smoking status, habit of exercise, BMI, SBP, AST, GGT, TC, TG, HbA1c, and FPG
Note 2: The model is not adjusted for the stratification variable in each case

ISSN: 1472-6823