The nonlinear correlation between alanine aminotransferase to high-density lipoprotein cholesterol ratio and the risk of diabetes: a historical Japanese cohort study

Table 4 Relationship between ALT/HDL-C ratio and the incident diabetes in different models

Variable	Model I (HR.,95% CI, P)	Model II (HR,95% CI, P)	Model III (HR,95% CI, P)	GAM (HR,95% CI, P)
ALT/HDL-C ratio	1.05 (1.04, 1.05) < 0.001	1.03 (1.02, 1.04) < 0.001	1.01 (1.00, 1.02) 0.049	1.01 (1.00, 1.02) 0.0318
ALT/HDL-C ratio (per SD)	1.65 (1.55, 1.74) < 0.001	1.38 (1.28, 1.50) < 0.001	1.11 (1.00, 1.24) 0.049	1.12 (1.00, 1.25) 0.0318
ALT/HDL-C ratio (quartile)
Q1	ref	ref	ref	ref
Q2	2.11 (1.19, 3.73) 0.031*	1.66 (0.94, 2.95) 0.249*	1.27 (0.71, 2.26) 0.999*	1.27 (0.70, 2.31) 0.999*
Q3	4.44 (2.63, 7.47) < 0.001*	2.65 (1.54, 4.58) 0.001*	1.81 (1.04, 3.14) 0.105*	1.87 (1.04, 3.35) 0.110*
Q4	10.68 (6.52, 17.50) < 0.001*	4.69 (2.70, 8.13) < 0.001*	2.24 (1.25, 4.02) 0.021*	2.52 (1.34, 4.74) 0.013*
P for trend	< 0.001	< 0.001	0.001	0.001

Model I: we did not adjust for other covariants
Model II: we adjusted for gender, age, ethanol consumption, smoking status, habit of exercise, BMI, and SBP
Model III: we adjusted for gender, age, ethanol consumption, smoking status, habit of exercise, BMI, SBP, AST, GGT, TC, TG, HbA1c, and FPG
GAM: we adjusted for gender, age, ethanol consumption, smoking status, habit of exercise, BMI, SBP, AST, GGT, TC, TG, HbA1c, and FPG. However, continuous covariates were adjusted as nonlinearity
HR Hazard ratio, CI Confidence interval, Ref Reference, SD Standard deviation, ALT/HDL-C ratio Alanine aminotransferase to high-density lipoprotein cholesterol ratio
^*represents that the Bonferroni correction for multiple comparisons was applied

ISSN: 1472-6823