Table 3 Occurrence and recovery of thyroid diseases
total (n = 1187) | male (n = 678) | female (n = 509) | p value | |
|---|---|---|---|---|
Rate of TD during treatment | 8.8% (105/1187) | 5.9% (40/678) | 12.8% (65/509) | 0 |
hyperthyroidism | 53.3% (56/105) | 45% (18/40) | 58.5% (38/65) | 0.525 |
subclinical hyperthyroidism | 5.7% (6/105) | 5% (2/40) | 6.2% (4/65) | |
hypothyroidism | 6.7% (7/105) | 7.5% (3/40) | 6.2% (4/65) | |
subclinical hypothyroidism | 34.3% (36/105) | 42.5% (17/40) | 29.2% (19/65) | |
Median time to TD (weeks) | 24 | 24 | 24 | 0.024 |
Baseline antibody positive | 18 | 0.009 | ||
Baseline antibody negative | 24 | |||
Symptom ratio of clinical TD | 25% (14/56) | 15% (3/20) | 30.6% (11/36) | 0.198 |
Rate of receiving antithyroid drugs or replacement therapy | 12.7% (7/55) | 15.8% (3/19) | 11% (4/36) | 0.621 |
normalization rate of TD at 24 weeks after discontinue treatment | 78.7% (74/94) | 84.8% (28/33) | 75.4% (46/61) | 0.286 |
Hyperthyroidism/subclinical hyperthyroidism | 74.5% (41/55) | 0.24 | ||
Hypothyroidism/subclinical hypothyroidism | 84.6% (33/39) |