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Table 2 Occurrence and recovery of thyroid autoantibodies

From: Analysis of clinical characteristics of thyroid disorders in patients with chronic hepatitis B treated with pegylated-interferon alpha

 

total (n = 1158)

male (n = 666)

female (n = 492)

p value

Antibodies positive rate during treatment

7.3% (85/1158)

4.4% (29/666)

11.4% (56/492)

0

    TGAb

4.2% (49/1158)

1.7% (11/666)

7.7% (38/492)

0

    TPOAb

4.4% (51/1158)

2.7% (18/666)

6.7% (33/492)

0.001

    TRAb

2.3% (27/1158)

1.1% (7/666)

4.1% (20/492)

0.001

Median time to antibody positive (weeks)

24

36

24

0.037

Negative conversion rates of antibody in 24 weeks

 TGAb

52.1% (25/48)

81.8% (9/11)

43.2% (16/37)

0.025

 TPOAb

30.6% (15/49)

25% (4/16)

33.3% (11/33)

0.553

 TRAb

53.6% (15/28)

62.5% (5/8)

50% (10/20)

0.857

  1. TGAb thyroglobulin antibody, TPOAb thyroid peroxidase antibody, TRAb thyrotropin receptor antibody