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Table 1 Association of TSHR mRNA expression with different variables of thyroid tumor patients

From: Targeting the inward rectifier potassium channel 5.1 in thyroid cancer: artificial intelligence-facilitated molecular docking for drug discovery

Variable

Cases (n = 68(%))

TSHR expression (2−ΔCt)

P-value

Gender

   

 Female

50(74)

0.1573(0.1033, 0.2166)

0.72

 Male

18(26)

0.1427(0.1288, 0.2689)

 

Age/yr

   

 <55

56(82)

0.1609(0.1279, 0.2541)

0.01 *

 ≥55

12(18)

0.1121(0.0751, 0.1555)

 

Tumor diameter/cm

   

 ≤2

58(85)

0.1518(0.1115, 0.2334)

0.77

 >2

10(15)

0.1450(0.1288, 0.2191)

 

Histological types

   

 Benign

6(9)

0.1483(0.1311, 0.1956)

0 *

 PTCa

36(53)

0.1292(0.0802, 0.1986)

 

 PTMCb

26(38)

0.1910(0.1458, 0.2721)

 

Lymph node metastasis

   

 Yes

41(60)

0.1473(0.1115, 0.2511)

0.91

 No

27(40)

0.1488(0.1275, 0.2193)

 

Vascular/capsular invasion

   

 Yes

28(41)

0.1327(0.0776, 0.1581)

0 *

 No

40(59)

0.1815(0.1393, 0.2627)

 

BRAF V600E

   

 Wild type

21(31)

0.1392(0.1221, 0.1928)

0.34

 Mutation

47(69)

0.1613(0.1217, 0.2451)

 

Stage

   

 Stage I

57(84)

0.1613(0.1253, 0.2468)

0 *

 Stage II+III

5(7)

0.0748(0.0383, 0.1043)

 
  1. a: papillary thyroid carcinoma
  2. b: papillary thyroid microcarcinoma
  3. *: Bold fonts indicate statistical significance.