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Table 1 In vivo effect of A1 and A2a Adenosine Receptor Antagonists on serum insulin concentration, liver glycogen content and Homeostatic assessment model

From: Dual A1 and A2A adenosine receptor antagonists, methoxy substituted 2-benzylidene-1-indanone, suppresses intestinal postprandial glucose and attenuates hyperglycaemia in fructose-streptozotocin diabetic rats

 

Serum insulin concentration (ρmol/L)

Homeostatic assessment model

Liver glycogen content (mg/g tissue)

HOMA-IR

HOMA-β

NC

70.63 ± 1.45a

1.65 ± 0.09a

313 ± 10.43a

20.87 ± 1.92a

DBC

34.51 ± 2.34e

3.86 ± 0.45e

5.6 ± 0,34f

4.24 ± 1.10e

DBI

58.17 ± 3.26b

1.84 ± 0,1b

75.76 ± 11.67b

17.83 ± 1,14b

DCA

45.90 ± 2,18d

2.02 ± 0.87bc

28.73 ± 6.23d

14.63 ± 1.39c

DIS

49.83 ± 1.04 cd

2.19 ± 0.76c

31.21 ± 5.75d

9.68 ± 0.58d

DPX

40.80 ± 2.02e

2.73 ± 0.35 cd

13.05 ± 0.95e

9.44 ± 0.74d

DMF

44.96 ± 3.45de

2.4 ± 0.98d

19.3 ± 9.45e

13.11 ± 1.03c

DGT

52.75 ± 2.97c

1.88 ± 0.23b

50.47 ± 2.74c

13.55 ± 1.46c

  1. Results are expressed as mean ± SD of six rats. a−e Different superscripts alphabets down the column indicate the significant difference (Tukey’s-HSD multiple range post hoc test, P < 0.05)
  2. NC, Normal Control; DBC, Diabetic Control; DBI, Diabetic + 2-BI; DCA, Diabetic + caffeine; DIS, Diabetic + istradefylline; DPX, Diabetic + DPXPC; DBM, Diabetic Metformin; DGT, Diabetic + pioglitazone