Fig. 4
(A) Effects of A1 and A2 AR antagonist on glucose tolerance. After the 24-day treatment period, Rats were fasted (18 h) overnight and blood glucose was measured at 0. 30, 90, and 120 min after the oral administration of glucose solution (2 g/kg b.w). (B) AUC data for 0–120 min post glucose injection were shown. Baseline subtraction for control mice was used to calculate AUC values for all groups, to ensure full treatment benefits are recognised. Values represent mean ± SD for 6 rats. a−c Different alphabets near the lines (4 A) or bar (4B) for a given time or group respectively for a given time represent significance of difference (p < 0.05). **P < 0.01 and ***P < 0.001 compared to Diabetic control group. NC, Normal Control; DBC, Diabetic Control; DBI, Diabetic + 2-BI; DCA, Diabetic + caffeine; DIS, Diabetic + istradefylline; DPX, Diabetic + DPXPC; DBM, Diabetic Metformin; DGT, Diabetic + pioglitazone