Principal component analysis of adipose tissue gene expression of lipogenic and adipogenic factors in obesity

BMC Endocrine Disorders

Table 4 Pearson correlation of pattern of the transcript level of adipogenic and lipogenic genes in subcutaneous and visceral adipose tissue of whole participants with adiposity indices and metabolic profile

		SPC1	SPC2	VPC1	VPC1
BMI,Kg/m²	Pearson Correlation	.160	-.492	.398	-.222
BMI,Kg/m²	p-value	ns	.001	.006	ns
WC,cm	Pearson Correlation	.154	-.530	.433	-.178
WC,cm	p-value	ns	.000	.003	ns
HC,cm	Pearson Correlation	.158	-.549	.440	-.281
HC,cm	p-value	ns	.000	.002	.059
WHR,-	Pearson Correlation	.032	-.104	.113	.237
WHR,-	p-value	ns	ns	ns	ns
WHtR,-	Pearson Correlation	.182	-.579	.369	-.219
WHtR,-	p-value	ns	.000	.012	ns
BAI,-	Pearson Correlation	.025	-.129	.118	-.380
BAI,-	p-value	ns	ns	ns	.009
VAI,-	Pearson Correlation	.131	-.445	.355	-.311
VAI,-	p-value	ns	.002	.015	.035
LAP,-	Pearson Correlation	.203	-.615	.335	-.305
LAP,-	p-value	ns	.000	.023	.039
AVI,-	Pearson Correlation	.140	-.429	.120	-.035
AVI,-	p-value	ns	.003	ns	ns
WWI,-	Pearson Correlation	.163	-.554	.329	-.145
WWI,-	p-value	ns	.000	.026	ns
CI,-	Pearson Correlation	.154	-.531	.434	-.183
CI,-	p-value	ns	.000	.003	ns
HOMA-IR,	Pearson Correlation	.202	-.374	.387	-.168
HOMA-IR,	p-value	ns	.011	.008	ns
Fasting Insulin, µU/mL	Pearson Correlation	.301	-.280	.306	-.190
Fasting Insulin, µU/mL	p-value	.042	.060	.038	.206

Four patterns were identified using principal component analysis for adipogenic and lipogenic genes in subcutaneous (SPC1 and SPC2) and visceral (VPC1 and VPC2) adipose tissue.
SPC1 was characterized by high transcript levels of SREBP1c, PPARγ, FAS, and ACC.
SPC2 was associated with C/EBPα and LXR α mRNA expression.
VPC1 was characterized by transcript levels of SREBP1c, FAS, and ACC.
VPC2 was identified by C/EBPα, LXR α, and PPARγ mRNA expression.
BMI, body mass index; VAI, visceral adiposity index; BAI, body adiposity index; VI, abdominal volume index; WWI, weight-adjusted waist index; CI; conicity index; WC, waist circumference; HC, hip circumference; WHR, waist-to-hip ratio; WHtR, Waist to Height Ratio; SBP, systolic blood pressure; DBP, diastolic blood pressure; FBG, fasting blood glucose; TG, triglycerides; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; AST, aspartate aminotransferase; ALT, alanine aminotransferase; AMH, anti-mullerian hormone; HOMA-IR, homeostasis model assessment of insulin resistance; HbA1c, hemoglobin A1C; ns,non-significant

ISSN: 1472-6823