Table 1 Clinical features of prolactinomas patients
From: Operative treatment of cystic prolactinomas: a retrospective study
Clinical features | Cystic prolactinoma (n = 41) | Solid microprolactinoma (n = 21) | Solid macroprolactinoma (n = 79) | P values cystic vs. micro, cystic vs. macro, micro vs. macro | ||
|---|---|---|---|---|---|---|
Age (years) | 29.39 ± 1.56 | 30.48 ± 1.79 | 38.25 ± 1.47 | 0.728* | < 0.001* | 0.007* |
Sex (%) | ||||||
Female | 27 (65.85%) | 19 (90.48%) | 38 (48.10%) | 0.063† | 0.064※ | < 0.001† |
Male | 14 (34.15%) | 2 (9.52%) | 41 (51.90%) | |||
Tumor size (cm) | 1.86 ± 0.10 | 0.77 ± 0.03 | 2.55 ± 0.14 | < 0.001* | < 0.001* | < 0.001* |
Knosp grades | ||||||
I | 7 (17.07%) | 20 (95.24%) | 12 (15.19%) | < 0.001† | < 0.001† | < 0.001† |
II | 26 (63.41%) | 1 (4.76%) | 22 (27.85%) | |||
III | 8 (19.51%) | 0 (0%) | 23 (29.11%) | |||
IV | 0 (0%) | 0 (0%) | 22 (27.85%) | |||
Clinical symptoms | ||||||
Visual defects (%) | 15 (36.59%) | 2 (9.52%) | 26 (32.91%) | 0.034† | 0.723※ | 0.032† |
Headache (%) | 12 (29.27%) | 6 (28.57%) | 28 (36.71%) | 0.954※ | 0.173※ | 0.555※ |
Amenorrhea or decreased libido (%) | 25 (60.98%) | 17 (80.95%) | 46 (58.23%) | 0.111※ | 0.771※ | 0.055※ |
Preoperative PRL level (ng/ml) | 350.66 ± 54.24 | 209.38 ± 27.16 | 900.36 ± 196.18 | 0.692* | 0.033* | 0.035* |
Total resection (%) | 36 (87.80%) | 21 (100%) | 59 (74.68%) | 0.157† | 0.093※ | 0.006† |
Indication for surgery | ||||||
Patients’ preference | 12 (29.27%) | 4 (19.05%) | 21 (26.58%) | 0.766※ | 0.977※ | 0.864※ |
DA-intolerance | 5 (12.20%) | 3 (14.29%) | 11 (13.92%) | |||
Persistent hyperprolactinemia | 13 (31.71%) | 9 (42.86%) | 27 (34.18%) | |||
Inadequate tumor shrinkage | 11 (26.83%) | 5 (23.81%) | 20 (25.32%) | |||
Early postop remission (%) | 27 (65.83%) | 17 (80.95%) | 32 (40.51%) | 0.215※ | 0.008※ | 0.001※ |
Follow-up remission (%) | 24 (58.54%) | 15 (71.43%) | 35 (44.30%) | 0.320※ | 0.139※ | 0.027※ |