Table 5 Acromegaly patients’ characteristics and pregnancy outcomes during gestation

Age at the diagnosis of pregnancy

47

27

0.793

 Average (SD)

31.4 ± 4.7

31.6 ± 4.9

31.3 ± 4.5

 Min-max

21–43

21–40

24–43

Diagnosis during pregnancy

9 (8.0)

9

14.06%

18

0

0%

14

0.006

Abortion

6 (4.1)

4

4.88%

0

2

3.17%

0

0.61

ART

6 (20.0)

1

11.1%

73

5

23.81%

42

0.462

Macroadenoma at the diagnosis of acromegaly

123 (91.8)

68

93.15%

9

55

90.16%

2

0.531

Previous treatment

 Surgery

121 (90.3)

60

84.51%

11

61

96.83%

0

0.016

 Radiotherapy

29 (28.2)

17

27.42%

20

12

29.27%

22

0.838

 Medical treatment

104 (71.7)

56

68.29%

0

48

76.19%

0

0.295

Medical treatment during pregnancy

64 (49.6)

36

48.00%

7

28

51.86%

9

0.666

Gestational diabetes mellitus

0

3

0.981

 Yes

10 (7.0)

6

7.32%

4

6.67%

 No

123 (86.6)

71

86.59%

52

86.67%

T2D before pregnancy

9 (6.3)

5

6.09%

4

6.67%

Gestational hypertension

0

1

0.153

 Yes

16 (11.1)

13

15.85%

3

4.84%

 No

117 (81.3)

63

76.83%

54

87.10%

 Eclampsia

1 (0.7)

1

1.22%

0

0

 Hypertension before pregnancy

10 (6.9)

5

6.09%

5

8.06%

Headaches

30 (27.5)

21

33.33%

19

9

19.57%

17

0.112

Delivery

52

34

0.460

 Vaginal

24 (40.0)

11

35.48%

13

44.83%

 Cesarean

36 (60.0)

20

64.52%

16

55.17%

Premature birth

7 (9.5)

6

16.67%

46

1

2.63%

25

0.114

  Gemellary pregnancy

1

2.78%

0

  Singleton pregnancy

5

13.89%

1

2.63%

Weight of newborns (kg)

44

38

0.57

  Average (SD)

3.26 ± 0.55

3.23 ± 0.63

3.31 ± 0.40

  Min-max

1.30–4.30

1.30–4.30

2.59–4.26

Weight of newborns

17

22

 Microsome

5 (4.7)

5

7.69%

0

0

0.069

 Macrosome

5 (4.7)

5

7.69%

0

0

0.069