Table 1 The main characteristic of included observational studies
First Author (Publication year) | Country/ Study design | Sex/ Sample size | Comorbid chronic disease | Method of measurement | Diagnostic criteria for T2DM/ Diabetes-related complications | Confounders | Adropin levels (Mean ± SD) ng/mL | |
|---|---|---|---|---|---|---|---|---|
Cases | Controls | |||||||
Addai et al. (2018) [96] | Iraq/ CC | F / 30 | PCOS | ELISA | HOMA - IR > 2.7/ None | Not adjusted | 0.14 ± 0.01 | 0.14 ± 0.01 |
Aydın et al. (2022) [99] | Turkey/ CS | B/ 50 | None | ELISA | NM/ None | Not adjusted | 0.26 ± 0.07 | 0.64 ± 0.39 |
Eshaghi et al. (2021) [100] | Iran/ CS | B/ 134 | None | ELISA | NM/ None | Not adjusted | 3.06 ± 0.46 | 4.21 ± 0.52 |
Hosseini et al. (2016) [27] | Iran/ CC | M / 80 | None | ELISA | ADA/ None | WHR, FBG, LDL-C, HOMA-IR, HbA1c | 2.5 ± 1.92 | 1.9 ± 1.46 |
Hu et al. (2018) [94] | China/ CS | B / 571 | None | ELISA | ADA/ Albuminuria | Sex and age | 2.71 ± 0.7 | 3.7 ± 1.31 |
Kutlu et al. (2019) [95] | Turkey/ CC | B / 81 | NAFLD | ELISA | HOMA - IR > 2.7/ None | Not adjusted | 0.6 ± 0.2 | 0.77 ± 0.32 |
Li, B et al. (2020) [93] | China/ CS | B / 447 | None | ELISA | ADA and WHO/ Albuminuria and retinopathy | Sex, age, BMI, duration of diabetes, SBP, DBP, TC, TG, LDL-C, HbA1c, HOMA-IR, CP, NEP and CHIT1 | 0.16 ± 0.01* | 0.16 ± 0.01 |
Li, N et al. (2021) [101] | China/ CS | B / 30 | NAFLD | ELISA | HOMA - IR > 2.7/ None | Not adjusted | 0.51 ± 0.73 | 4 ± 3.52 |
Li, S et al. (2019) [91] | China/ CS | B / 233 | None | ELISA | ADA/ Retinopathy | Sex and age | 2.5 ± 0.6 | 3.84 ± 1.48 |
Palizban et al. (2019) [92] | Iran/ CC | B / 146 | None | ELISA | ADA/ None | Not adjusted | 12.32 ± 2.98 | 9.51 ± 2.73 |
Shah et al. (2021) [102] | India/ CS | B/ 100 | None | ELISA | ADA/ None | Not adjusted | 2.12 ± 0.12 | 3.82 ± 0.4 |
Shelest et al. (2018) [97] | Ukraine/ CS | B / 119 | Hypertension and Obesity | ELISA | EASD/ Hypertension and obesity | Not adjusted | 2.74 ± 0.78 | 4.9 ± 0.58 |
Wu et al. (2014) [24] | China/ CS | B / 392 | Suspected coronary artery disease | ELISA | ADA/ Suspected coronary artery disease | Sex, age, BMI | 4.8 ± 1.48 | 5.53 ± 1.62 |
Zang et al. (2018) [98] | China/ CS | B / 176 | None | ELISA | ADA/ None | Sex, age, BMI, smoking and drinking, SBP, DBP, TC, TG, LDL-C, HDL-C, hs-CRP | 4.1 ± 1.88 | 5.7 ± 3.2 |
Zhang et al. (2020) [103] | China/ CS | B/ 224 | None | ELISA | None/ retinopathy | Not adjusted | 0.012 ± 0.011 | 0.18 ± 0.008 |