Table 6 Bivariable and Multivariable analysis showing patient factors associated with hypothyroidism

Age category

 6 months < 5 years

133

111 (83.5)

22 (16.5)

1

 5–10 years

117

93 (79.5)

24 (20.5)

1.3 (0.69–2.47)

0.419

 >10 years

82

68 (82.9)

14 (17.1)

1.04 (0.50–2.17)

0.919

Sex

 Female

167

144 (86.2)

23 (13.8)

1

 Male

165

128 (77.6)

37 (22.4)

1.81 (1.02–3.21)

0.042

1.96 (1.09–3.53)

0.025

Hydroxyurea

 No

106

83 (78.3)

23 (21.7)

1

 Yes

226

189 (83.6)

37 (16.4)

0.71 (0.40–1.26)

0.241

Family history of thyroid disease

 No

314

256 (81.5)

58 (18.5)

1

 Yes

18

16 (88.9)

2 (11.1)

0.55 (0.12–2.47)

0.436

Maternal HIV status

 Negative

310

256 (82.6)

54 (17.4)

1

 Positive

18

12 (66.7)

6 (33.3)

2.37 (0.85–6.59)

0.098

Acute chest syndrome

 No

329

271 (82.4)

58 (17.6)

1

 Yes

3

1 (33.3)

2 (66.7)

9.34 (0.83-104.79)

0.07

Constipation

 No

315

261 (82.9)

54 (17.1)

1

 Yes

17

11 (64.7)

6 (35.3)

2.64 (0.93–7.44)

0.067

3.05 (1.04–8.97)

0.043

Hemoglobin concentration mean (sd)

8.05 (1.23)

7.75 (1.3)

0.82 (0.65–1.03)

0.092

Hematocrit mean (sd)

25.26 (3.45)

24.45 (3.38)

0.93 (0.86–1.01)

0.1

Number of hospitalizations*

1.23 (0.98–1.53)

0.072

1.22 (0.97–1.53)

0.087