Clinical observation of menopause hormone therapy in postmenopausal women with euthyroid and mild subclinical hypothyroidism

Table 2 Thyroid and reproductive endocrine hormone parameters in euthyroid and subclinical hypothyroidism postmenopausal women, before and after MHT

Variable	Group I (n = 460)	Group II (n = 106)	Group III (n = 21)	F/H	p value^a
TSH (mIU/L)
Before MHT	1.46 (1.08, 1.88)	3.12 (2.73, 3.64)	5.14 (4.86, 6.09)	300.526	0.000
After MHT	1.75 (1.24, 2.21)	2.74 (2.29, 3.22)	5.17 (3.09, 6.19)	68.322	0.000
t/Z	5.050	2.559	0.847
p value^b	0.000	0.010	0.397
fT3 (pmol/L)
Before MHT	4.38 (3.96, 4.73)	4.45 (3.96, 4.87)	4.37 (4.13, 4.79)	1.276	0.528
After MHT	4.26 (3.91, 4.58)	4.19 (3.87, 4.66)	3.96 (3.47, 4.23)	2.683	0.070
t/Z	1.999	1.557	2.929
p value^b	0.047	0.119	0.013
fT4 (pmol/L)
Before MHT	13.82 (12.64, 15.04)	13.22 (12.38, 14.78)	13.33 (11.69, 14.74)	5.175	0.075
After MHT	13.36 (12.33, 14.58)	13.26 (12.32, 14.50)	12.83 (10.97, 14.13)	2.749	0.253
t/Z	3.181	1.153	0.853
p value^b	0.001	0.249	0.410
LH(IU/L)
Before MHT	36.42 (27.98, 46.59)	35.70 (27.98, 43.43)	40.27 (28.83, 43.54)	1.054	0.590
After MHT	31.75 (24.11, 42.51)	31.38 (22.57, 41.14)	29.71 (19.06, 38.40)	0.941	0.625
t/Z	6.157	2.252	1.614
p value^b	0.000	0.024	0.123
FSH(IU/L)
Before MHT	77.30 (63.89, 93.33)	75.08 (64.00, 90.96)	72.90 (54.75, 85.98)	2.341	0.310
After MHT	52.11 (39.51, 67.48)	51.61 (36.89, 67.47)	42.59 (34.16, 62.75)	2.002	0.368
t/Z	14.473	6.070	4.842
p value^b	0.000	0.000	0.000
E₂ (pmol/L)
Before MHT	18.35 (18.35, 33.97)	18.40 (18.35, 38.05)	18.35 (18.35, 18.52)	7.828	0.020^c
After MHT	71.41 (18.40, 170.30)	87.43 (25.51, 212.15)	79.38 (22.40, 193.30)	2.677	0.262
t/Z	10.970	6.059	3.294
p value^b	0.000	0.000	0.001

Data are expressed as medians (25th percentile, 75th percentiles)
p < 0.05 was considered statistically significant
^ap values are for between-group differences by Kruskal–Wallis H test/one way ANOVA
^bp values are for within-group differences by Wilcoxon signed-rank test or paired-samples t test
^cp < 0.05 and further between-group differences by post hoc test with Bonferroni correction as follows:
I vs. II Z = -26.895, p = 0.311; I vs. III Z = -72.162 p = 0.100; II vs. III Z = -99.057, p = 0.019
Abbreviation: MHT menopause hormone therapy, TSH thyroid stimulating hormone, fT3 free tri-iodothyronine, fT4 free thyroxine, LH luteinizing hormone, FSH follicle-stimulating hormone, E₂, estradiol

ISSN: 1472-6823