Table 4 Distribution of genotypic, allelic frequencies and genetic models of LHCGR variants (rs2293275 and rs12470652) between PCOS cases and controls

rs2293275

GG

138 (32.8)

120 (37.2)

Reference

GA

162 (38.4)

135 (42)

0.04*

1.04

0.7 to 1.45

0.8

AA

121 (28.8)

67 (20.8)

1.7

(1.15 to 2.5)

0.006*

G

438 (52)

374 (58)

0.02*

Reference

A

404 (48)

270 (42)

1.3 (1.03 to 1.5)

0.02*

Dominant model

G/G

G/A + A/A

138

283

120

203

0.2

-

0.21

0.89 to 1.64

-

0.2

Recessive model

G/A + G/G

A/A

300

121

255

67

0.01*

-

1.53

1.09 to 2.16

-

0.01*

Heterozygous model

G/G + A/A

G/A

259

162

186

136

0.34

-

0.85

0.63 to 1.14

-

0.3

rs12470652

TT

402 (95)

314 (97.5)

Reference

TC

11 (3)

7 (2.2)

0.13

1.2

(0.47 to 3.2)

0.67

CC

8 (2)

1 (0.3)

6.2

(0.7 to 50.2)

0.08

T

815 (97)

635 (98.6)

0.02*

Reference

C

27 (3)

9 (1.4)

2.3

(1.09to 5.3)

0.02*

Dominant model

T/T

T/C + C/C

402

19

314

8

0.14

-

1.8

(0.8 to 4.2)

-

0.14

Recessive model

T/T + T/C

C/C

413

8

321

1

0.04*

-

6.2

(0.77 to 49.7)

-

0.08

Heterozygous model

T/T + C/C

T/C

410

11

315

7

0.69

-

1.2

(0.4 to 3.1)

-

0.7