Association of cardiometabolic risk factors with insulin resistance in overweight and obese children

Daneshzad, Elnaz; Rostami, Sayeh; Aghamahdi, Fatemeh; Mahdavi-Gorabi, Armita; Qorbani, Mostafa

doi:10.1186/s12902-022-01245-7

BMC Endocrine Disorders

Table 3 Association between anthropometric and biochemical measures with insulin level and HOMA-IR in obese children: linear regression analysis

From: Association of cardiometabolic risk factors with insulin resistance in overweight and obese children

Variables	Ln Insulin level					Ln HOMA-IR
Variables	β	95% CI	P-value	R2	Adjusted R2	β	95% CI	P-value	R2	Adjusted R2
zBMI
Crude model	0.275	(0.190, 0.360)	< 0.001	0.215	0.210	0.282	(0.186, 0.378)	< 0.001	0.185	0.180
Adjusted model	0.177	(0.077, 0.276)	0.001	0.279	0.265	0.188	(0.076, 0.301)	0.001	0.242	0.226
WC (cm)
Crude model	0.002	(0.000, 0.004)	0.027	0.033	0.026	0.002	(0.000, 0.004)	0.041	0.028	0.021
Adjusted model	0.001	(-0.001, 0.003)	0.212	0.227	0.211	0.001	(-0.001, 0.003)	0.268	0.192	0.175
WHtR
Crude model	3.038	(1.610, 4.467)	< 0.001	0.107	0.101	2.711	(1.097, 4.324)	0.001	0.069	0.063
Adjusted model	2.781	(1.513, 4.050)	< 0.001	0.307	0.293	2.453	(0.984, 3.923)	0.001	0.242	0.226
NC (cm)
Crude model	0.036	(0.017, 0.054)	< 0.001	0.090	0.084	0.032	(0.011, 0.053)	0.003	0.059	0.053
Adjusted model	0.019	(0.001, 0.038)	0.039	0.241	0.225	0.016	(-0.005, 0.037)	0.137	0.197	0.181
Wrist circumference (cm)
Crude model	0.071	(0.035, 0.108)	< 0.001	0.092	0.086	0.082	(0.042, 0.123)	< 0.001	0.099	0.093
Adjusted model	0.001	(-0.001, 0.003)	0.212	0.227	0.211	0.058	(0.018, 0.098)	0.005	0.228	0.212
TG (mg/dl)
Crude model	0.002	(0.001, 0.004)	< 0.001	0.081	0.075	0.003	(0.001, 0.004)	< 0.001	0.091	0.084
Adjusted model	0.001	(0.000, 0.002)	0.038	0.301	0.281	0.002	(0.000, 0.003)	0.014	0.273	0.253
Cholesterol (mg/dl)
Crude model	0.002	(-0.001, 0.004)	0.264	0.008	0.002	0.003	(0.000, 0.006)	0.096	0.019	0.012
Adjusted model	0.001	(-0.002, 0.003)	0.488	0.282	0.262	0.002	(-0.001, 0.005)	0.146	0.253	0.232
LDL (mg/dl)
Crude model	0.000	(-0.001, 0.002)	0.797	0.000	-0.006	0.001	(-0.001, 0.002)	0.643	0.001	-0.005
Adjusted model	0.000	(-0.001, 0.001)	0.795	0.280	0.260	0.001	(-0.001, 0.002)	0.980	0.242	0.221
HDL (mg/dl)
Crude model	-0.008	(-0.015, -0.001)	0.034	0.030	0.024	-0.004	(-0.013, 0.004)	0.290	0.008	0.001
Adjusted model	-0.004	(-0.011, 0.002)	0.215	0.287	0.267	0.000	(-0.008, 0.007)	0.900	0.242	0.221
FBG (mg/dl)
Crude model	0.017	(0.007, 0.026)	0.001	0.073	0.067	0.026	(0.016, 0.036)	< 0.001	0.149	0.144
Adjusted model	0.010	(0.001, 0.018)	0.028	0.303	0.284	0.020	(0.010, 0.029)	< 0.001	0.321	0.302

CI confidence interval, HOMA-IR Homeostatic Model Assessment for Insulin Resistance, zBMI Z score of body mass index, WC waist circumference, WHtR Waist to height ratio, NC neck circumference, TG Triacylglycerols, LDL low-density lipoprotein, HDL high-density lipoprotein, FBG fasting blood glucose
Adjusted model: Variables were controlled for age and gender. Moreover, biochemical variables were adjusted for one more confounder (BMI)
P-values obtained by linear regression analysis. Hence the distribution of insulin level and HOMA-IR were not normal, the analyses were performed using by logarithmic variables (Ln)

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