Clinical characteristics of patients with unexplainable hypothalamic disorder diagnosed by the corticotropin-releasing hormone challenge test: a retrospective study

Table 3 Comparison of symptoms between groups

	NR n = 18	unexplainable-HD n = 18	explainable-HD n = 38	PD n = 15
Chronic fatigue	4 (22.2)	18 (100.0) ^b	8 (21.1) ^d	11 (73.3) ^b
Depressive state	0 (0)	5 (27.8) ^b	0 (0) ^d	0 (0) ^d
Insomnia	0 (0)	4 (22.2) ^a	0 (0) ^d	1 (6.7)
Appetite loss	1 (5.6)	0 (0)	6 (15.8)	3 (20.0)
Nausea	0 (0)	1 (5.6)	3 (7.9)	4 (26.7) ^a
Weight loss	2 (11.1)	4 (22.2)	1 (2.6)	2 (13.3)
Slight fever	0 (0)	2 (11.1)	2 (5.3)	0 (0)
Arthritis/myalgia	0 (0)	2 (11.1)	2 (5.3)	0 (0)
Visual disturbance	4 (22.2)	0 (0)	12 (31.6) ^c	1 (6.7)
Headache	1 (5.6)	2 (11.1)	4 (10.5)	4 (26.7)
Dizziness	0 (0)	2 (11.1)	2 (5.3)	0 (0)
Asymptomatic	7 (38.9)	0 (0) ^a	10 (26.3)	0 (0) ^a

Categorical data were compared using the chi-square test corrected by Bonferroni’s method for multiple comparisons. Data are expressed as n (%). ^aP < 0.05 and ^bP < 0.01 compared with the NR group, and ^cP < 0.05 and ^dP < 0.01 compared with the unexplainable-HD group. Explainable-HD explainable-hypothalamic disorder group, n number of patients, NR normal response group, PD pituitary disorder group, unexplainable-HD unexplainable-hypothalamic disorder group

ISSN: 1472-6823